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44 (0,143s) •

Project

The risk factors of the liver and bile ducts injury in the preoperative period of the donor (ND6607)

In the preoperative period, there are a number of risk factors which may cause infury to donor organs. The aim to establish - using bile analysis and bile duct histochemistry - the impact of these factors on the quality of the liver...

FJ - Chirurgie včetně transplantologie

  • 2001 - 2003
    • •
  • 1 630 tis. Kč
    • •
  • 1 564 tis. Kč
    • •
  • MZ
Project

Analysis of bile acids as a new, non-invasive method for diagnosing gastroesophageal reflux disease and screening of Barrett’s esophagus. (NU23-08-00303)

Barrett’s esophagus and esophageal adenocarcinoma. Bile acids have been shown of bile acids is however complex and their conjugation status and pH are the major diagnostic methods are not able to analyze individual bile ac...

Gastroenterology and hepatology

  • 2023 - 2026
    • •
  • 12 604 tis. Kč
    • •
  • 12 604 tis. Kč
    • •
  • MZ
Project

Biliary glycoproteins as the carriers of pronucleation activity and markers of malignant proceses in bile tract. (IZ4046)

Aim of study: 1. To ConA positive glycoproteins in bile. 2. To characterize proteins with pronucleation activity in the ConA negative fraction. 3. To identify proteins bound to the vesicular fraction of cholesterol. Aims of study: 4. To dete...

FE - Ostatní obory vnitřního lékařství

  • 1997 - 1999
    • •
  • 2 730 tis. Kč
    • •
  • 2 470 tis. Kč
    • •
  • MZ
Project

Bile salt malabsorption in patients with Crohn´s disease as a factor predisposing for pigment gallstone formation (NK7707)

Aim of the study is to assess the malabsorption of bile-acids in pts with Crohn´s disease as the predisposition factor of pigment cholelithiasis by detection of 7 alpha hydroxy-4-cholesten-3-ons in blood specimens.......

FP - Ostatní lékařské obory

  • 2003 - 2005
    • •
  • 1 785 tis. Kč
    • •
  • 1 746 tis. Kč
    • •
  • MZ
Project

Cholesterol 7alpha-hydroxylase polymorphism as a predictor cholesterolemia responsiveness (NT13151)

-week therapy with bile acid sequestrant by more pronounced decrease sensitivity induced by changes in bile acid metabolism after sequestrant administration will be studied in healthy volunteers. It will be also analyzed how the cha...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2012 - 2015
    • •
  • 5 177 tis. Kč
    • •
  • 5 177 tis. Kč
    • •
  • MZ
Project

The importance of examination of donor bile and biliary tract for evaluating the quality of the liver graft (NK4905)

A prerequisite for a successful liver Tx is to obtain a quality organ. The aim of the project is to evaluate the importance of the biochemical examination of bile and immunohistochemical examination of the biliary tract of the donor to asses...

FE - Ostatní obory vnitřního lékařství

  • 1998 - 2000
    • •
  • 1 719 tis. Kč
    • •
  • 1 543 tis. Kč
    • •
  • MZ
Project

Novel interventions for the treatment of triglycerides, cholesterol and bile acids diseases with human CAR ligands (GA19-14497S)

regulates important genes controlling glucose, lipid, cholesterol and bile acids data, if CAR stimulates or repress triglyceride and bile acid synthesis under and bile acids metabolism and homeostasis using genetically mod...

Pharmacology and pharmacy

  • 2019 - 2021
    • •
  • 12 826 tis. Kč
    • •
  • 12 662 tis. Kč
    • •
  • GA ČR
Project

Supramolecular systems in chemical biology (OC10001)

The objective of the project is a synthesis of convenient synthons of supramolecular systems based on phytosterol units, or in combination with bile acid units, designing of their conjugates with small molecules, and investigation of their p...

CC - Organická chemie

  • 2010 - 2012
    • •
  • 1 500 tis. Kč
    • •
  • 1 500 tis. Kč
    • •
  • MŠMT
Project

Bile acid malabsorption in oncology patients. Concept 3P Medicine (prevention of bile acid malabsorption associated complications, prediction, and personalization) (NW25-09-00063)

Bile acid malabsorption (BAM) is a common condition observed, as a complication and is associated with minimal radiation dose. The mainstay of treatment for BAM is bile acid sequestrants. They bind the bile acids and preven...

Oncology

  • 2025 - 2028
    • •
  • 11 941 tis. Kč
    • •
  • 11 171 tis. Kč
    • •
  • MZ
Project

The effect of the preoperative period on the bile ducts injury of the cadaveric donor liver graft (NR8108)

A number of risk factors is present in the preoperative period of cadaveric donor. The goal is to determine, using immunohistochemical testing of the bile ducts, the effect of these factors on the quality of the donor organ. The second goal ...

FJ - Chirurgie včetně transplantologie

  • 2004 - 2006
    • •
  • 2 747 tis. Kč
    • •
  • 2 646 tis. Kč
    • •
  • MZ
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