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42 (0,095s) •

Project

Mechanisms of action of Bordetella type III secretion effector BteA (GJ18-16772Y)

understanding of Bordetella pertussis pathogenesis. The functional type III secretion system (T3SS) of Bordetella is required for bacterial persistence in the lower respiratory is expected to make significant advances in the field ...

Microbiology

  • 2018 - 2021
    • •
  • 8 081 tis. Kč
    • •
  • 8 081 tis. Kč
    • •
  • GA ČR
Project

Actions of Bordetella pertussis effector protein BteA in respiratory epithelia (GA21-05466S)

Classical Bordetella species colonize cilia of mammalian respiratory epithelia and cause respiratory infections, such as the whooping cough disease of humans caused by Bordetella pertussis and B. parapertussis. These pathogenic bact...

Cell biology

  • 2021 - 2023
    • •
  • 9 724 tis. Kč
    • •
  • 9 724 tis. Kč
    • •
  • GA ČR
Project

Targeted drug design for bioterrorism prevention. Development of effective inhibitors of the adenylate cyclase toxin of Bordetella pertusis and Bacillus anthracis. (VG20102015046)

The aim of the proposed project of applied research is design and biological activity study of potential antibacterial drugs applicable during the act of bioterrorism. It is focused on pathogens causing whooping cough (Bordetella pertusis in...

CC - Organická chemie

  • 2010 - 2015
    • •
  • 41 350 tis. Kč
    • •
  • 41 345 tis. Kč
    • •
  • MV
Project

Role of the pore-forming activity in adenylate cyclase toxin action and Bordetella virulence (GAP302/12/0460)

The adenylate cyclase toxin-hemolysin (CyaA) is a multifunctional RTX protein playing a key role in virulence of pathogenic Bordetella. It translocates an adenylate cyclase enzyme into cytosol of host phagocytes and subverts their bactericid...

CE - Biochemie

  • 2012 - 2016
    • •
  • 15 307 tis. Kč
    • •
  • 15 307 tis. Kč
    • •
  • GA ČR
Project

Development of an immunization preparation to protect against the causative agent of whooping cough (FW12010329)

The project's basic goal is to develop a preparation for mucosal immunization against infection by the causative agent of whooping cough, the bacterium Bordetella pertussis (whooping cough). A preparation in the form of a mucoadhesive lyophi...

Epidemiology

  • 2025 - 2027
    • •
  • 24 412 tis. Kč
    • •
  • 17 055 tis. Kč
    • •
  • TA ČR
Project

Biogenesis and function of the type III secretion system tip filament in the genus Bordetella (GA24-11053S)

Bordetella species are important pathogens of diverse mammals, including humans, to study Bordetella extracellular T3SS components that form an interface between......

Infectious Diseases

  • 2024 - 2026
    • •
  • 12 714 tis. Kč
    • •
  • 12 714 tis. Kč
    • •
  • GA ČR
Project

Nature and role(s) of the posttranslational modification(s) required for activities of an RTX toxin the adenylate cyclase toxin of bordetella pertussis (GA310/95/1048)

EE - Mikrobiologie, virologie

  • 1995 - 1997
    • •
  • 1 030 tis. Kč
    • •
  • 1 030 tis. Kč
    • •
  • GA ČR
Project

Mechanisms underlying survival of the whooping cough agent inside human phagocytes (7AMB14AR028)

The goal of this project is to develop a coordinated collaboration and the necessary synergy of the Czech and Argentinian teams that are about to apply complementary approaches to studies on intracellular survival of the whooping cough agent Bord...

EE - Mikrobiologie, virologie

  • 2014 - 2015
    • •
  • 320 tis. Kč
    • •
  • 320 tis. Kč
    • •
  • MŠMT
Project

Development of a new pharmaceutical form for the oromucosal administration of vaccines (FV40365)

for application into oral cavity. The Bordetella pertussis vaccine strain is selected...

Epidemiology

  • 2019 - 2021
    • •
  • 14 006 tis. Kč
    • •
  • 9 760 tis. Kč
    • •
  • MPO
Project

Molecular mechanisms of membrane interaction and translocation of adenylate cyclase toxin from Bordetella pertussis (GA15-09157S)

The multifunctional adenylate cyclase toxin (CyaA) is a key virulence factor of Bordetella pertussis that causes a highly contagious respiratory disease called pertussis or whooping cough. CyaA is a fusion of an N-terminal adenylate cyclase ...

CE - Biochemie

  • 2015 - 2017
    • •
  • 5 994 tis. Kč
    • •
  • 5 994 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 42