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Projects

46 projects (0,096s) •

Project

Actions of Bordetella pertussis effector protein BteA in respiratory epithelia (GA21-05466S)

by Bordetella pertussis and B. parapertussis. These pathogenic bacteria employ a type IIIClassical Bordetella species colonize cilia of mammalian respiratory epithelia in modulation of ciliated respiratory epithelia and in...

Cell biology

  • 2021 - 2023
    • •
  • 9 724 tis. Kč
    • •
  • 9 724 tis. Kč
    • •
  • GA ČR
Project

Interactions of Bordetella pertussis virulence factors with host cells (GA19-12695S)

Bordetella pertussis causes the respiratory infectious disease called pertussis the adenylate cyclase toxin (CyaA), the pertussis toxin (PT) and the filamentous. pertussis virulence in vivo and on the role...

Microbiology

  • 2019 - 2021
    • •
  • 9 821 tis. Kč
    • •
  • 9 821 tis. Kč
    • •
  • GA ČR
Project

Transcriptomics of Bordetella pertussis and human phagocytes interplay (GF16-34825L)

Bordetella pertussis is the causative agent of human whooping cough, a highly vaccinated populations. B. pertussis has been traditionally viewed as a typical, it was demonstrated that B. pertussis cells upon inf...

EB - Genetika a molekulární biologie

  • 2016 - 2020
    • •
  • 6 942 tis. Kč
    • •
  • 6 942 tis. Kč
    • •
  • GA ČR
Project

Mechanisms of action of Bordetella type III secretion effector BteA (GJ18-16772Y)

understanding of Bordetella pertussis pathogenesis. The functional type III secretion system (T3SS) of Bordetella is required for bacterial persistence in the lower respiratoryWhooping cough (pertussis) occurrence...

Microbiology

  • 2018 - 2021
    • •
  • 8 081 tis. Kč
    • •
  • 8 081 tis. Kč
    • •
  • GA ČR
Project

Concerted toxin action in Bordetella pertussis virulence (GX19-27630X)

of its protein toxins, the whooping cough agent Bordetella pertussis compromises. A set of specifically mutated B. pertussis strains will be used for intranasal eliciting the initial pertussis phase coryza and ena...

Microbiology

  • 2019 - 2023
    • •
  • 49 158 tis. Kč
    • •
  • 49 158 tis. Kč
    • •
  • GA ČR
Project

Development of a new pharmaceutical form for the oromucosal administration of vaccines (FV40365)

for application into oral cavity. The Bordetella pertussis vaccine strain is selected (pertussis, diphtheria, measles, rubella, mumps, tetanus, TB, etc.) The aim......

Epidemiology

  • 2019 - 2021
    • •
  • 14 006 tis. Kč
    • •
  • 9 760 tis. Kč
    • •
  • MPO
Project

Mechanisms underlying survival of the whooping cough agent inside human phagocytes (7AMB14AR028)

Bordetella pertussis inside human phagocytes. By joint efforts the virulence factors generation pertussis vaccines....

EE - Mikrobiologie, virologie

  • 2014 - 2015
    • •
  • 320 tis. Kč
    • •
  • 320 tis. Kč
    • •
  • MŠMT
Project

Mechanisms of immunomodulatory action of Bordetella pertussis virulence factors (GA13-14547S)

young to be fully vaccinated. Rational improvement of the acellular pertussis, hampered by our poor understanding of the molecular mechanisms that underlie Bordetella pertussis capacities to subvert and evade host innate a...

EE - Mikrobiologie, virologie

  • 2013 - 2017
    • •
  • 14 608 tis. Kč
    • •
  • 14 608 tis. Kč
    • •
  • GA ČR
Project

Contribution of regulatory RNAs to the pathogenesis of Bordetella pertussis (GA23-05634S)

Bordetella pertussis is a Gram-negative strictly human respiratory pathogen and the causative agent of whooping cough (pertussis). Surprisingly, this highly contagious for virulence of B. pertussis. This suggests t...

Microbiology

  • 2023 - 2025
    • •
  • 12 258 tis. Kč
    • •
  • 12 258 tis. Kč
    • •
  • GA ČR
Project

Translation Omics technologies into better understanding of Bordetella pertussis pathogenicity (NV16-30782A)

Bordetella pertussis is the causative agent of human whooping cough (pertussis-preventable infectious disease. Despite generalized vaccination, pertussis is again in pertussis cases has been mostly attribu...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2016 - 2019
    • •
  • 10 854 tis. Kč
    • •
  • 10 611 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 46