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5 686 (0,191s) •

Project

New approaches to Chimeric Antigen Receptor T cells analysis of RASAL3 protein function and identification of novel CAR-T activity-modifying genes (GA22-35273S)

Chimeric Antigen Receptor (CAR) T cells achieved remarkable success in treating to the original promises. Novel designs of CAR-T cells are urgently needed with further potential for augmenting

Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)

  • 2022 - 2024
    • •
  • 8 916 tis. Kč
    • •
  • 8 814 tis. Kč
    • •
  • GA ČR
Project

Development of highly effective allogenic CAR T-cells based on innovative surface proteome analysis and non-viral approaches (NW25-03-00298)

Cell therapies based on chimeric antigen receptor (CAR) T-cells represent of allogenic CAR T-cells by applying the state-of-the-art molecular, cellular, proteomic and/or immunotargets. Fu...

Cell biology

  • 2025 - 2028
    • •
  • 16 192 tis. Kč
    • •
  • 16 192 tis. Kč
    • •
  • MZ
Project

Next generation CAR-T cells for the therapy of hematological malignancies (NU23-03-00188)

-generation CAR-T cells that have enhanced antitumor activity, e.g. by co-expression malignancies such as AML, B-ALL and B-NHL using CAR-T T lymphocytes. The aim of the project is to build on the ...

Hematology

  • 2023 - 2026
    • •
  • 13 368 tis. Kč
    • •
  • 13 368 tis. Kč
    • •
  • MZ
Project

The development of chimeric antigen receptors for the immunotherapy of lymphoma. (NT14030)

T cells will be obtained from the blood of patients with B-NHL will work out procedures for large-scale T cell cultivation under GMP quality settings modified cells. After expansion in vitro we will test t...

FD - Onkologie a hematologie

  • 2013 - 2015
    • •
  • 7 435 tis. Kč
    • •
  • 7 435 tis. Kč
    • •
  • MZ
Project

Pre-clinical validation of cGMP production of CAR T-cells for solid tumorstherapy (NV19-08-00147)

Chimeric antigen receptor (CAR) T-cell is a cutting edge technology for targeted cell therapy of oncologic diseases. Promising clinical results were reported. Here we propose to validate protocols for the producti...

Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)

  • 2019 - 2023
    • •
  • 14 420 tis. Kč
    • •
  • 14 420 tis. Kč
    • •
  • MZ
Project

Development of advanced analytical kits for monitoring immunotherapy using CAR T lymphocytes (EI22_002/0000680)

The subject of the project is research and development focused on advanced analytical kits based on flow cytometry for detection and quantification of CAR-T cells used for immunotherapy of hematological malignancies - leuke...

Other medical science

  • 2023 - 2026
    • •
  • 12 114 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • MPO
Project

Genetically modified donor T cells as a universal cell source for the immunotherapy of tumors using T lymphocytes equipped with a chimeric antigen receptor (CAR) (FV40145)

donor's T-cell that will be genetically manipulated to be universally usable for any donor T-cells that will be further manipulated by genetic methods to express a chimeric antigen receptor (CAR) on thei...

Oncology

  • 2019 - 2022
    • •
  • 15 604 tis. Kč
    • •
  • 10 922 tis. Kč
    • •
  • MPO
Project

Development of methods for cellular and gene therapy of hematological malignancies. (NV15-34498A)

. Next, we propose to develop methods for selective expansion of T cells specific. This novel treatment method is based on the use adoptively transferred T lymphocytes molecule designated Chimeric Antigen Receptor (CAR<...

FD - Onkologie a hematologie

  • 2015 - 2019
    • •
  • 14 055 tis. Kč
    • •
  • 14 055 tis. Kč
    • •
  • MZ
Project

Advanced Immunomonitoring and Immunotherapy of Hematological and Hemato-oncological Patients (EF16_025/0007428)

in treated patients, the construction of a new generation of CAR T-lymphocytes. escape mechanisms of leukemic cells, that should serve for the selection of procedures for the expansion of T-lymphocytes capable of ...

Immunology

  • 2018 - 2022
    • •
  • 101 850 tis. Kč
    • •
  • 24 545 tis. Kč
    • •
  • MŠMT
Project

CAR-iNKT cells for the treatment of multiple myeloma (NW24-03-00079)

immunocompetent cells that are activated and multiplied ex vivo. CAR T lymphocytes are already CAR cells and increasing the chance of complete elimination of target cells. Allogeneic therapy usi...

Hematology

  • 2024 - 2027
    • •
  • 10 663 tis. Kč
    • •
  • 10 663 tis. Kč
    • •
  • MZ
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