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Organisation and function of CD4 co-receptor on the surface of T cells at nanoscale (GA15-06989S)
CD4 glycoprotein functions as a co-receptor for the activation of T cells of T cells. Different pools of CD4 molecules involved in TCR signalling expand our knowledge of CD4 function in <...
EC - Imunologie
- 2015 - 2019 •
- 7 753 tis. Kč •
- 7 753 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2015 - 25. 4. 2019
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Distinct roles of IL-2 for antigen-primed CD8+ and CD4+ T cells a paradigm shift in T cell biology and implication for cancer immunotherapy (GA25-16348S)
+ and CD4+ T cells. This project aims to change the current paradigm in the field, but it is a dispensable cytokine for activated CD4+ T cells and it can even dampen their expansion, in particular...
Immunology
- 2025 - 2027 •
- 8 997 tis. Kč •
- 8 997 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2025 - 31. 12. 2027
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Topological regulation of CD4 and CD8 in T cells (GA19-07043S)
Co-receptors CD4 and CD8 are essential for the development and function of T cells. However, molecular mechanism how CD4, and to some extend CD8, modulate T cell and topology of T cel...
Immunology
- 2019 - 2022 •
- 8 341 tis. Kč •
- 7 947 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2019 - 30. 6. 2022
Uznané náklady
Podpora ze státního rozpočtu (95%)
Poskytovatel: Grantová agentura České republiky
Role of virus-associated host-derived proteins in virus induced T cell dysfunction (GAP304/10/1161)
, are enveloped viruses, which infect CD4 T cells and cause transient (VZV) or progressive (SIV) dysregulation of T cell function. This effect is mainly indirect of these host cell proteins will b...
EC - Imunologie
- 2010 - 2016 •
- 4 685 tis. Kč •
- 4 685 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2010 - 7. 4. 2016
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Intracellular complement alterations in patients with allergic eosinophilic asthma. (NU20-05-00146)
activation of CD4+ T cells. This process is influenced also by intracellular complement system. Activation of CD4+ T cells can be pharmacologically influenced by vitamin D is focused on changes o...
Immunology
- 2020 - 2025 •
- 12 372 tis. Kč •
- 12 290 tis. Kč •
- MZ
Řešení projektu: 1. 5. 2020 - 31. 12. 2025
Uznané náklady
Podpora ze státního rozpočtu (99%)
Poskytovatel: Ministerstvo zdravotnictví
Immunoregulatory functions in children with diabetes mellitus (NR9355)
This project deals with a possible supression of autoagressive T cell clones leading to the destruction of insulin producing beta cells by immunoregulatory CD4+CD25+ T cells in children with type ...
EC - Imunologie
- 2007 - 2009 •
- 10 398 tis. Kč •
- 10 386 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2007 - 31. 12. 2009
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
T cell receptor signaling and fate decisions made by peripheral T cells in homeostasis and during inflammation (GJ16-09208Y)
Proper T cell fate choices are required for efficient immune responses as well as for maintaining self-tolerance. Incorrect T cell fate decisions may trigger allergy, autoimmunity, or immunodeficiency. T <...
EC - Imunologie
- 2016 - 2018 •
- 9 315 tis. Kč •
- 7 968 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2016 - 31. 12. 2018
Uznané náklady
Podpora ze státního rozpočtu (86%)
Poskytovatel: Grantová agentura České republiky
Experimental model of colitis. Dysregulation of the immune response to the gut microflora (GA303/00/1370)
-germ free, CD4+ CD45RBhigh T cell reconstituted SCID mice monoassociatedThe aim of the project is to determine a role CD4+ CD45RBhigh T lymphocytes of experimental colitis occuring in CD4+ CD45RB...
EC - Imunologie
- 2000 - 2002 •
- 2 558 tis. Kč •
- 2 160 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2000 - 1. 1. 2002
Uznané náklady
Podpora ze státního rozpočtu (84%)
Poskytovatel: Grantová agentura České republiky
DOES ANY SPECIFIC IMBALANCE IN CYTOKINES OF T HELPER CELL ORIGINE ASSOCIATE WITH CANCER AND ITS RESPONSE TO CYTOKINE-BASED THERAPY? (NC5571)
The significance of the changes in CD4+ T helper lymphocyte-derived cytokines and CD mononuclear cell profiles in cancer-associated immune impairment and response to cytokine-based immunotherapy of cancer.......
FD - Onkologie a hematologie
- 1999 - 2001 •
- 5 179 tis. Kč •
- 5 179 tis. Kč •
- MZ
Řešení projektu: 1. 1. 1999 - 1. 1. 2001
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Effect of long-term asymptomatic Toxoplasma gondii infection on the immune and clinical state of HIV-positive patients (NT11429)
to compare immunological parameters (CD4+ and CD8+ T lymphocytes, NK cells or expression of CD 38 and HLA-DR on T lymphocytes and IgA, IgG, IgM immunoglobulins) as well......
FN - Epidemiologie, infekční nemoci a klinická imunologie
- 2010 - 2014 •
- 4 338 tis. Kč •
- 4 338 tis. Kč •
- MZ
Řešení projektu: 1. 10. 2010 - 31. 12. 2014
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
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