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Projects

46 projects (0,149s) •

Project

Evaluation of cyclin-dependent kinase inhibitors in cancer cell lines with specific genetic alterations (GAP305/12/0783)

Synthetic inhibitors of cyclin-dependent kinases (CDK) have been developed experiences with the development of CDK inhibitors, including synthesis, biochemical application is to study molecular mechanisms of action of our newly prep...

CE - Biochemie

  • 2012 - 2014
    • •
  • 5 873 tis. Kč
    • •
  • 5 873 tis. Kč
    • •
  • GA ČR
Project

Chemical genetic analysis of role of cyclin-dependent kinases in cancer cell lines (GJ15-17282Y)

Cyclin-dependent kinases (CDKs) are universal eukaryotic protein regulators that promote cell cycle, initiation of DNA replication, and mitosis. Why CDKs/cyclins of CDK1-cyclin B complex can be overcome by modulating CDK ac...

CE - Biochemie

  • 2015 - 2017
    • •
  • 3 665 tis. Kč
    • •
  • 3 665 tis. Kč
    • •
  • GA ČR
Project

Innovative preparation and verification of CDK and GSK kinases (FW02020128)

The main goal of the project is the design and synthesis of new, innovative, safety components that use as inhibitory cyclin-dependent kinases (CDKs) and glycogen synthase kinases (GSKs) that can be used in combat, schizophrenia, depression,...

Organic chemistry

  • 2020 - 2023
    • •
  • 5 352 tis. Kč
    • •
  • 4 125 tis. Kč
    • •
  • TA ČR
Project

Regulation of gene expression by a new mRNA-binding factor (GA16-10930S)

, making it the first mRNA-binding CDK. We hypothesize that the mRNA-binding activity of the CDK plays an important and unrecognized role in the regulation of gene expression. By characterizing CDK- mRNA-binding properties,...

EB - Genetika a molekulární biologie

  • 2016 - 2020
    • •
  • 9 396 tis. Kč
    • •
  • 9 396 tis. Kč
    • •
  • GA ČR
Project

Inhibition of hepatocellular carcinoma progression (7AMB12AT011)

to study anticancer activity of cyclin-dependent kinase (CDK) inhibitors in hepatocellular carcinoma. The Czech group developed highly active CDK inhibitors to preclinically test the CDK inhibitors for activities against l...

CE - Biochemie

  • 2012 - 2013
    • •
  • 139 tis. Kč
    • •
  • 139 tis. Kč
    • •
  • MŠMT
Project

The changes in the activity of cyclin dependent kinases and in phophorylation of their target proteins during the algal cell cycle under presence of.. (IAC5020012)

up to now. Complexes of cyclin dependent kinases (CDK) and cyclins are the key phases is dependent on the activity of these complexes. Not only substrates of CDK of the project proposed is to follow the changes of the CDK-...

EA - Morfologické obory a cytologie

  • 2000 - 2000
    • •
  • 229 tis. Kč
    • •
  • 149 tis. Kč
    • •
  • AV ČR
Project

Regulation of mitosis by WEE1 inhibitory kinase in the green alga Chlamydomonas reinhardtii (IAA500200614)

Regulation of mitosis is one of the most studied but still not completely characterized processes. The progression through mitosis is regulated by cyclin-dependent kinases (CDKs) in complex with mitotic cyclins. These CDK complexes ...

EB - Genetika a molekulární biologie

  • 2006 - 2010
    • •
  • 4 457 tis. Kč
    • •
  • 4 457 tis. Kč
    • •
  • AV ČR
Project

The effect of cyclin dependent kinase on chloroplast division in green algae of genera Chlamydomonas and Scenedesmus (KJB5020305)

on the activity of cyclin-dependent kinases (CDK) during cell cycle of algae dividing investigating the functional relation of plastokinesis on CDK, attention will be paid rings in the plastid division plane and that could be a tar...

EA - Morfologické obory a cytologie

  • 2003 - 2005
    • •
  • 2 408 tis. Kč
    • •
  • 2 060 tis. Kč
    • •
  • AV ČR
Project

Modulation of cell division of normal and cancer cells by cyclin-dependent kinase inhibitors (GA301/08/1649)

Cyclin-dependent kinases (cdks) are critical regulators of cell cycle progression and RNA transcription. A variety of genetic events cause universal overactivity of the cell cycle cdks in human cancers, ant their inhibition can lead...

FD - Onkologie a hematologie

  • 2008 - 2012
    • •
  • 6 985 tis. Kč
    • •
  • 6 985 tis. Kč
    • •
  • GA ČR
Project

Inhibitors of cyclin-dependent kinases (cdc 2, cdk 2) derived from olomoucine (GA301/96/0437)

CE - Biochemie

  • 1996 - 1996
    • •
  • 0 tis. Kč
    • •
  • 1 956 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 46