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13 (0,131s) •

Project

The role of protein kinase Aurora-A in resumption of meiosis of mouse oocytes. (GA305/06/1413)

in mitosis where also CDK1 activity is necessary. CDK1 is regulated, in addition. Removing these phosphorylations and hence activation of CDK1 is carry out by CDC25 dual-A inthe CDK1 activation during resumption o...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2006 - 2008
    • •
  • 2 180 tis. Kč
    • •
  • 2 180 tis. Kč
    • •
  • GA ČR
Project

Chemical genetic analysis of role of cyclin-dependent kinases in cancer cell lines (GJ15-17282Y)

cannot compensate for an absence of CDK1-cyclin B for entry into mitosis is still of CDK1-cyclin B complex can be overcome by modulating CDK activities in cancer cells. We expect to achieve this using synthetic tunable CDK1

CE - Biochemie

  • 2015 - 2017
    • •
  • 3 665 tis. Kč
    • •
  • 3 665 tis. Kč
    • •
  • GA ČR
Project

The signaling pathways synchronizing nuclear envelope break down, chromosome condensation a spindle formation during mammalian meiosis of oocytes (LH12057)

The main goal of the project is to characterize the functions and roles of indirect (AURKA and PLK1 signaling) and direct (CDC25A) regulators of CDK1 activity in the synchronization of processes such as nuclear envelope break down, chromosom...

EB - Genetika a molekulární biologie

  • 2012 - 2015
    • •
  • 5 449 tis. Kč
    • •
  • 3 491 tis. Kč
    • •
  • MŠMT
Project

Biological activity of new inhibitors of cyclin-dependent kinases (GP204/03/D231)

The discovery of olomoucine as one from the first specific inhibitors of cyclin-dependent kinases (cdk1, cdk2, cdk5) markedly stimulated the development of new generation of antimitotic drugs. Olomoucine and its novel derivatives with increa...

CE - Biochemie

  • 2003 - 2006
    • •
  • 1 483 tis. Kč
    • •
  • 583 tis. Kč
    • •
  • GA ČR
Project

CDC25 phosphatases ? key regulator of mammalian oocytec maturation and early embryonic development (ME08030)

in microtubules followed by first polar body extrusion. These events are CDK1 dependent). Generation of CDC25B -/- mice revealed an essential function for CDC25B in CDK1......

EB - Genetika a molekulární biologie

  • 2008 - 2011
    • •
  • 3 328 tis. Kč
    • •
  • 1 600 tis. Kč
    • •
  • MŠMT
Project

Development of new generation of cyclin-dependent kinase inhibitors structure-activity relationships, molecular and in vitro mechanisms of action (GA303/02/0875)

We have discovered unusual specificity of purine derivative olomoucine (OC; 2-(2-hydroxyethylamino)- 6-benzylamino-9-methylpurine) toward cell cycle kinases (CDK1, CDK2, CDK5, ERK1). The design and inhibitory activity of OC was further towar...

CE - Biochemie

  • 2002 - 2004
    • •
  • 11 161 tis. Kč
    • •
  • 2 302 tis. Kč
    • •
  • GA ČR
Project

Interplay between cdk kinase and MAP kinase pathway during maturation of oocytes and their fertilization - a model for cell cycle control in somatic and maligna (ME 189)

, specific role of cdk1 and cdk2 kinases and their regulattory subunits - cyclins A and B...

ED - Fyziologie

  • 1998 - 2001
    • •
  • 1 750 tis. Kč
    • •
  • 1 050 tis. Kč
    • •
  • MŠMT
Project

Biological activity of synthetic inhibitors of cyclin-dependent kinases (GA204/08/0511)

During our previous projects we have developed several new inhibitors of cyclin-dependent kinases. Most of the described inhibitors showed a preference for CDK1 and CDK2, important regulators of the cell cycle. However, olomoucine II, which ...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 3 200 tis. Kč
    • •
  • 3 200 tis. Kč
    • •
  • GA ČR
Project

Pyrazolo[4,3-d]pyrimidines as a new generation of anticytokinines and inhibitors of cyclin-dependent kinases (KJB4038301)

We found a new specific activity of pyrazolo[4,3-d]pyrimidines, viz. the ability to inhibit kinases of the cell division cycle (CDK1, CDK2, CDK4) and induce the apoptosis of tumor cell lines. In this project we want to study the structure an...

CC - Organická chemie

  • 2003 - 2005
    • •
  • 3 654 tis. Kč
    • •
  • 924 tis. Kč
    • •
  • AV ČR
Project

Purine inhibitors of cyclin-dependent kinases as anticancer and antimitotic compounds (GA301/02/0475)

to discovery of roscovitine, which displays an enhanced inhibitory activity toward CDK1...

EB - Genetika a molekulární biologie

  • 2002 - 2004
    • •
  • 30 494 tis. Kč
    • •
  • 4 823 tis. Kč
    • •
  • GA ČR
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