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2 830 (0,224s) •

Project

Intestinal organoids as an in-vitro model for predicting the response to therapies correcting molecular defects in cystic fibrosis (NU20-07-00049)

differs among patients with the identical CFTR genotype. We presume that the therapeutic response is also affected by non-CFTR genes, called disease modifying CFTR genotype. Modifying genes that can contr...

Paediatrics

  • 2020 - 2023
    • •
  • 11 461 tis. Kč
    • •
  • 11 461 tis. Kč
    • •
  • MZ
Project

Study of CFTR gene mutations in chronic pancreatitis,Crohn disease and cancers of oesphagus, small and large intestine and pancreas. (IZ3526)

Projectmight elucidate pathogenetic role of CFTR mutations,of intragenic and extragenic polymorfisms in the increased risk of digestive system cancers,revealed in adult cystic fibrosis patients. Significance of CFTR gene mu...

FG - Pediatrie

  • 1996 - 1999
    • •
  • 2 735 tis. Kč
    • •
  • 2 234 tis. Kč
    • •
  • MZ
Project

Mutations and polymorphisms of the CFTR gene in the pathogenesis of chronic respiratory, gastrointestinal diseases and severe reproductive disorders (NE6464)

Cystic fibrosis is caused by mutations in CFTR gene, 890 mutations have been, while the phenotypic effect of most CFTR gene mutations is significantly influenced preliminary results we will study the distribution o...

FC - Pneumologie

  • 2001 - 2003
    • •
  • 2 516 tis. Kč
    • •
  • 2 516 tis. Kč
    • •
  • MZ
Project

Genetic cauases of male infertility and chronic pancreatitis analysis of CBAVD/azoospermic patients and patients with idiopathic chronic pancreatitis from ethnically related populations of the Czech Republic and Poland. (ME 451)

Identification of cystic fibrosis (CF) CFTR gene mutations and Y chromosomal will test for CFTR gene mutations, including mutations in the cathionic trypsinogen (protease serine I- PRSSI) and SPINK I (serine protea...

FP - Ostatní lékařské obory

  • 2001 - 2001
    • •
  • 300 tis. Kč
    • •
  • 280 tis. Kč
    • •
  • MŠMT
Project

Study of CFTR gene mutations, of genotype and phenotype correlations for early prevention, diagnosis and treatment of cystic fibrosis (GA301/95/1606)

EB - Genetika a molekulární biologie

  • 1995 - 1997
    • •
  • 1 950 tis. Kč
    • •
  • 1 950 tis. Kč
    • •
  • GA ČR
Project

Idiopathic chronic pancreatitis in Czech Republic (genetic, hereditary and autoimmune-related etiology) (NR8431)

Hereditary, genetic and autoimmune induced form of CP in the Czech republic. Idiopatic and hereditary chronic pancreatitis....

FE - Ostatní obory vnitřního lékařství

  • 2005 - 2007
    • •
  • 2 463 tis. Kč
    • •
  • 2 428 tis. Kč
    • •
  • MZ
Project

Genetic causes of male infertility Analysis of CBAVD and azoospermic patients from ethnicaly close population of Slovenia and of the Czech Republic (ME 258)

infertility with regards to mutations in the CFTR gene and contribute toThe overal goal of this project is to determine whether a portion of individuals with CBAVD (congenital bilateral absence of vas deferens) and azoospermia /obs...

EB - Genetika a molekulární biologie

  • 1998 - 2000
    • •
  • 1 705 tis. Kč
    • •
  • 405 tis. Kč
    • •
  • MŠMT
Project

Polymorphisms in FSH- and androgen receptor genes and in the CFTR gene in the pathogenesis of severe reproductive disorders and in pharmacogenetic prevention of ovarian hyperstimulation syndrome (NR9448)

association of CFTR gene mutations and polymorphisms to reproductive disordersThe subject of this project is ascertainment of the relationship between polymorphisms of FSH/LH receptors genes influencing the fine endocrine ...

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 7 821 tis. Kč
    • •
  • 7 789 tis. Kč
    • •
  • MZ
Project

Optimalization of newborn screening of cystic fibrosis (NS9986)

Newborn screening for cystic fibrosis (NSCF) is based on examination of concentration of imunoreactive trypsinogen (IRT) and DNA analysis of CFTR gene in blood spots on screening cards. DNA analysis could be replaced with pancreatit...

FG - Pediatrie

  • 2008 - 2011
    • •
  • 10 604 tis. Kč
    • •
  • 10 597 tis. Kč
    • •
  • MZ
Project

Optimization of cystic fibrosis patient-derived cellular models to asses restoration of CFTR function in patients with cystic fibrosis (NU23-07-00079)

conductance regulator (CFTR) protein has opened the era of cystic fibrosis (CF) curative of therapeutic response differs among patients with the identical CFTR genotype. Intestinal epithelial cells highly expressing CFTR a...

Paediatrics

  • 2023 - 2026
    • •
  • 15 195 tis. Kč
    • •
  • 15 195 tis. Kč
    • •
  • MZ
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