All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”
EN
ČeštinaEnglish

Filters

3 046 (0,211s) •

Project

Intestinal organoids as an in-vitro model for predicting the response to therapies correcting molecular defects in cystic fibrosis (NU20-07-00049)

The discovery of modulators that target cystic fibrosis transmembrane conductance regulator (CFTR) protein has opened the era of CF curative treatment. Although differs among patients with the identical CFTR genotype. We pr...

Paediatrics

  • 2020 - 2023
    • •
  • 11 461 tis. Kč
    • •
  • 11 461 tis. Kč
    • •
  • MZ
Project

Optimization of cystic fibrosis patient-derived cellular models to asses restoration of CFTR function in patients with cystic fibrosis (NU23-07-00079)

The discovery of modulators that target cystic fibrosis transmembrane conductance regulator (CFTR) protein has opened the era of cystic fibrosis (CF) curative of therapeutic response differs among patients with the identical CFT...

Paediatrics

  • 2023 - 2026
    • •
  • 15 195 tis. Kč
    • •
  • 15 195 tis. Kč
    • •
  • MZ
Project

Mutations and polymorphisms of the CFTR gene in the pathogenesis of chronic respiratory, gastrointestinal diseases and severe reproductive disorders (NE6464)

Cystic fibrosis is caused by mutations in CFTR gene, 890 mutations have been, while the phenotypic effect of most CFTR gene mutations is significantly influenced preliminary results we will study the distribution of CFTR mu...

FC - Pneumologie

  • 2001 - 2003
    • •
  • 2 516 tis. Kč
    • •
  • 2 516 tis. Kč
    • •
  • MZ
Project

Study of CFTR gene mutations in chronic pancreatitis,Crohn disease and cancers of oesphagus, small and large intestine and pancreas. (IZ3526)

Projectmight elucidate pathogenetic role of CFTR mutations,of intragenic and extragenic polymorfisms in the increased risk of digestive system cancers,revealed in adult cystic fibrosis patients. Significance of CFTR gene mutations i...

FG - Pediatrie

  • 1996 - 1999
    • •
  • 2 735 tis. Kč
    • •
  • 2 234 tis. Kč
    • •
  • MZ
Project

Molecular genetic charakteristic of CFTR gne mutations with atypical course of cystic fibrosis. (IZ2899)

Detection of CFTR mutations leading to infertility,congenit. disordes of the uropoetic system,malabsorption,deafness,nasal polyp.,chronic respiratory infect.,asthma and chronic pancereatit. to improve their prevent.and therapy,in childhood a...

FG - Pediatrie

  • 1995 - 1999
    • •
  • 3 530 tis. Kč
    • •
  • 3 160 tis. Kč
    • •
  • MZ
Project

Risk factors leading to diabetes mellitus in patients with cystic fibrosis in the Czech republic (NB6461)

Impaired glucose tolerance and diabetes mellitus in patients with cystic fibrosis. Relation of clinical parameters, CFTR genotype and markers of insulitis (HLA class II., antibodies IAA, IA-2 GAD). Determination of the risk factors, optimali...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2001 - 2003
    • •
  • 3 105 tis. Kč
    • •
  • 3 043 tis. Kč
    • •
  • MZ
Project

Genetic cauases of male infertility and chronic pancreatitis analysis of CBAVD/azoospermic patients and patients with idiopathic chronic pancreatitis from ethnically related populations of the Czech Republic and Poland. (ME 451)

Identification of cystic fibrosis (CF) CFTR gene mutations and Y chromosomal microdeletions of the DAZ locus in patients with congenital bilateral absence of vas will test for CFTR gene mutations, including mutations in the cathioni...

FP - Ostatní lékařské obory

  • 2001 - 2001
    • •
  • 300 tis. Kč
    • •
  • 280 tis. Kč
    • •
  • MŠMT
Project

Study of CFTR gene mutations, of genotype and phenotype correlations for early prevention, diagnosis and treatment of cystic fibrosis (GA301/95/1606)

EB - Genetika a molekulární biologie

  • 1995 - 1997
    • •
  • 1 950 tis. Kč
    • •
  • 1 950 tis. Kč
    • •
  • GA ČR
Project

New trends in the treatment of cystic fibrosis. (IZ2056)

FG - Pediatrie

  • 1994 - 1998
    • •
  • 4 384 tis. Kč
    • •
  • 5 168 tis. Kč
    • •
  • MZ
Project

AGING PREVENTION – Simultaneous modulation of ABAD and mTOR signaling pathway (NV19-09-00578)

ABAD modulators as possible therapeutics against aging, in particular, drugWithin our project, we would like to develop a new class of anti-aging drugs - drugs intended to slow aging process. In past, we investiga...

Pharmacology and pharmacy

  • 2019 - 2023
    • •
  • 9 582 tis. Kč
    • •
  • 9 582 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 3 046