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13 640 (0,098s) •

Project

Role of BCR-ABL in CML cases with poor response to therapy but with low BCR-ABL transcript levels (NC7550)

In some of CML patients with poor response to treatment we have found low BCR-ABL transcript levels. We will study the role of BCR-ABL as well as BCR and ABL in order to find out whether CML mechanism may be independent of BCR-ABL i...

FD - Onkologie a hematologie

  • 2003 - 2005
    • •
  • 6 625 tis. Kč
    • •
  • 6 510 tis. Kč
    • •
  • MZ
Project

Identification of novel therapeutic targets in chronic myeloid leukemia via systematic analysis of BCR-ABL interactome (NV15-34405A)

Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder arising inhibitors (TKIs) is a frontline in treatment of the CML. While majority of the CML that the CML patients often acquire BCR-ABL mutatio...

EB - Genetika a molekulární biologie

  • 2015 - 2018
    • •
  • 11 982 tis. Kč
    • •
  • 11 982 tis. Kč
    • •
  • MZ
Project

Chronic myeloid leukemia radiation risk estimation based on BCR-ABL distances in hemotopoietic cells (GA202/02/0804)

chronic myeloid leukemia (CML) risk. Ionizing radiation is a well-studied carcinogen known to cause CML and CML is well-undestood, homogenous and prevalent. CML is known to becaused by a translocation between ABL ...

BG - Jaderná, atomová a molekulová fyzika, urychlovače

  • 2002 - 2004
    • •
  • 3 714 tis. Kč
    • •
  • 1 746 tis. Kč
    • •
  • GA ČR
Project

Targeted gene silencing using siRNAs in primary cell cultures of CML patients and leukemic cell lines (K562, MOLM-7, KU-812) (NR7989)

In the project siRNAs will be used for gene expression silencing of the genes MMP8,MMP9,PCNA,MAPK p38,Bmi-1,BCR/ABL in CML-derived leukemic cell lines and in primary cultures obtained with cultivation of peripheral blood leukocytes from ...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 3 699 tis. Kč
    • •
  • 3 291 tis. Kč
    • •
  • MZ
Project

Immunotherapy of chronic myeloid leukemia Development and testing of experimental vaccines in mouse model and immunological study in CML patients (NR9075)

to determine the immune profile of CML patients and its changes in the course...

FD - Onkologie a hematologie

  • 2006 - 2008
    • •
  • 20 075 tis. Kč
    • •
  • 19 330 tis. Kč
    • •
  • MZ
Project

Molecular markers of chronic myeloid leukemia progression to blast crisis. (NC5902)

We shall search for early markers of CML progression into acute phase to be able to interrupt this progression with timely treatment. As possible markers,we shall identify the genes differentially expressed in different stages of CML

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 6 639 tis. Kč
    • •
  • 6 390 tis. Kč
    • •
  • MZ
Project

The miRNA expression diversity study in chronic myelogeneous leukemia (GP301/08/P154)

Chronic myelogeneous leukemia (CML) is a malignant disorder caused by abnormal(9;22) (q34;q11). A great progress in CML treatment was achieved by tyrosine kinase appeared in some patients. CML is clinically heterogeneous di...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 993 tis. Kč
    • •
  • 993 tis. Kč
    • •
  • GA ČR
Project

Spectrum of NGS detected somatic mutations and their association with prognosis and outcome of adolescent and young adult patients with Ph-positive leukemias (NU21-07-00225)

. Currently, most patients with chronic myeloid leukemia in chronic phase (CML-CP) have of TKIs it seems that younger patients with CML-CP at age 15-39, defined by National - CML and Ph positive acute lymphoblastic leukemia...

Oncology

  • 2021 - 2024
    • •
  • 16 307 tis. Kč
    • •
  • 16 307 tis. Kč
    • •
  • MZ
Project

Hydrological estimates from radiowave propagation in terrestial microwave network (GA17-16389S)

(CMLs) as novel sensor for high-resolution monitoring of fluxes associated experiments with CMLs of different characteristics and deterministic modelling for water fluxes quantification from CMLs including their uncertaint...

BK - Mechanika tekutin

  • 2017 - 2019
    • •
  • 6 554 tis. Kč
    • •
  • 6 539 tis. Kč
    • •
  • GA ČR
Project

Utilization of centrosomal proteins for prognostication and vaccinotherapy of chronic myeloid leukemia (NT13862)

Search for prognostic markers of chronic myelogenous leukemia (CML) and development of DNA vaccines against this disease based on increased production and antibodies against the corresponding proteins in CML patients at disease diag...

FD - Onkologie a hematologie

  • 2012 - 2015
    • •
  • 9 681 tis. Kč
    • •
  • 9 681 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 13 640