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77 (0,063s) •

Project

Developing CRISPR-PRIME for fruit development and seed dormancy studies (8J22FR026)

of ECR. A protocol for the CRISPR-PRIME genome editing method will be developed in France and rapeseed in the Czech Republic) and know-how (CRISPR-PRIME in France......

Plant sciences, botany

  • 2022 - 2023
    • •
  • 156 tis. Kč
    • •
  • 156 tis. Kč
    • •
  • MŠMT
Project

Exploring non-canonical ORFs with functions in DNA damage repair (EH22_010/0008995)

The number of annotated genes has not changed significantly since the sequencing of the human genome 20 years ago. However, recent technological advances have revealed that our genome's protein-coding capacity is greater than previously thought, givin...

Genetics and heredity (medical genetics to be 3)

  • 2025 - 2028
    • •
  • 3 904 tis. Kč
    • •
  • 988 tis. Kč
    • •
  • MŠMT
Project

CRISPR-Cas barley genome editing prospective tool for modern breeding (GA17-07805S)

Drought is a major environmental stress factor, which has begun to negatively affect yield of cereal crops. Method of stable genetic barley transformation will be used for novel, very efficient and easy-to-design genome editing by CRISPR-Cas...

GE - Šlechtění rostlin

  • 2017 - 2021
    • •
  • 7 016 tis. Kč
    • •
  • 6 969 tis. Kč
    • •
  • GA ČR
Project

The application of CRISPR-Cas9 for the creation of multiple mutants in the genes coding for the nascent polypeptide associated complex (LTC20050)

-associated complex by the modern genome-editing techniques (CRISPR-Cas9), (2 by CRISPR-TSKO....

Plant sciences, botany

  • 2020 - 2023
    • •
  • 4 863 tis. Kč
    • •
  • 4 863 tis. Kč
    • •
  • MŠMT
Project

Comprehensive CRISPR-based functional analysis of deubiquitinases (DUBs) in cellular transformation for the discovery of new targets in cancer therapy (GA21-21413S)

approach based on CRISPR-Cas9 genome modification technologies. We will study (1...

Biochemistry and molecular biology

  • 2021 - 2024
    • •
  • 10 011 tis. Kč
    • •
  • 10 011 tis. Kč
    • •
  • GA ČR
Project

Novel test for classical and variant Niemann-Pick type C disease. Evaluation of pathogenicity of frequent NPC1 alleles implicated in late-onset NPC. (NV16-33923A)

CRISPR-Cas9 and evaluated using the Chol/Dex-based test to determine...

FH - Neurologie, neurochirurgie, neurovědy

  • 2016 - 2019
    • •
  • 5 589 tis. Kč
    • •
  • 5 589 tis. Kč
    • •
  • MZ
Project

Advancement of chicken transgenic technology and its biotechnological application (QK1810344)

1) Construction of expression vectors with targetted expression of recombinant proteins into egg white 2) Construction of CRISPR/Cas chicken Tva receptor editing vectors 3) Derivation and subsequent transfection of PGC of selected chicken li...

GM technology (crops and livestock), livestock cloning, marker assisted selection, diagnostics (DNA chips and biosensing devices for the early/accurate detection of diseases) biomass feedstock production technologies, biopharming

  • 2018 - 2021
    • •
  • 6 370 tis. Kč
    • •
  • 5 178 tis. Kč
    • •
  • MZe
Project

New therapeutic targets in overcoming radioresistance Systematic identification of genes driving response to radiation through the integration of functional genomics and transcriptomic profiling (NW24-03-00221)

therapeutic targets. In contrast to biomarker studies, CRISPR-based functional genomics. Integration of transcriptomic profiling of clinical samples with results of CRISPR......

Oncology

  • 2024 - 2027
    • •
  • 14 956 tis. Kč
    • •
  • 14 956 tis. Kč
    • •
  • MZ
Project

Identification of genes controlling nondisjunction of the maize B chromosome (GA23-04887S)

genes. To validate candidates, we will knock-out B-linked genes using CRISPR/Cas9...

Plant sciences, botany

  • 2023 - 2025
    • •
  • 7 717 tis. Kč
    • •
  • 7 717 tis. Kč
    • •
  • GA ČR
Project

Functional genetics of the model dioecious plant Silene latifolia (GA17-00567S)

and in vitro regeneration in order to introduce genome editing nucleases (TALEN, CRISPR/Cas...

EB - Genetika a molekulární biologie

  • 2017 - 2019
    • •
  • 5 805 tis. Kč
    • •
  • 5 451 tis. Kč
    • •
  • GA ČR
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