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Projects

887 projects (0,204s) •

Project

Resistance to monoclonal antibody therapy at B-CLL and B-lymphomas its foundations and potential intervention strategies (NV15-33561A)

will perform rescue screen with inhibitors of epigenetic modifying enzymes and a whole genome loss-of-function screen using novel state-of-the-art technique......

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 9 253 tis. Kč
    • •
  • 9 253 tis. Kč
    • •
  • MZ
Project

New approaches to Chimeric Antigen Receptor T cells analysis of RASAL3 protein function and identification of novel CAR-T activity-modifying genes (GA22-35273S)

in a mouse model. In addition, using a CRISPR/Cas9 knockout library, we will interrogate...

Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)

  • 2022 - 2024
    • •
  • 8 916 tis. Kč
    • •
  • 8 814 tis. Kč
    • •
  • GA ČR
Project

Novel test for classical and variant Niemann-Pick type C disease. Evaluation of pathogenicity of frequent NPC1 alleles implicated in late-onset NPC. (NV16-33923A)

CRISPR-Cas9 and evaluated using the Chol/Dex-based test to determine...

FH - Neurologie, neurochirurgie, neurovědy

  • 2016 - 2019
    • •
  • 5 589 tis. Kč
    • •
  • 5 589 tis. Kč
    • •
  • MZ
Project

Mechanism of non-mutational p53 inactivation in human cancers and its implication for cancer therapy (GJ19-18177Y)

50 % of cancers retain wild-type p53 but its function is often restricted. Despite the tremendous knowledge about p53, the mechanisms underlying non-mutational inactivation are unknown. To identify essential factors that govern p53 function, we will ...

Oncology

  • 2019 - 2022
    • •
  • 7 281 tis. Kč
    • •
  • 7 281 tis. Kč
    • •
  • GA ČR
Project

The application of CRISPR-Cas9 for the creation of multiple mutants in the genes coding for the nascent polypeptide associated complex (LTC20050)

-associated complex by the modern genome-editing techniques (CRISPR-Cas9), (2 by CRISPR-TSKO....

Plant sciences, botany

  • 2020 - 2023
    • •
  • 4 863 tis. Kč
    • •
  • 4 863 tis. Kč
    • •
  • MŠMT
Project

Comprehensive CRISPR-based functional analysis of deubiquitinases (DUBs) in cellular transformation for the discovery of new targets in cancer therapy (GA21-21413S)

approach based on CRISPR-Cas9 genome modification technologies. We will study (1...

Biochemistry and molecular biology

  • 2021 - 2024
    • •
  • 10 011 tis. Kč
    • •
  • 10 011 tis. Kč
    • •
  • GA ČR
Project

The role of SCF-FBXO28 ubiquitin ligase in cancer progression (GA18-27408S)

CRISPR/CAS9 genetic screen and biochemical analysis of associated protein complexes...

Cell biology

  • 2018 - 2022
    • •
  • 8 559 tis. Kč
    • •
  • 7 833 tis. Kč
    • •
  • GA ČR
Project

Identification of genes controlling nondisjunction of the maize B chromosome (GA23-04887S)

genes. To validate candidates, we will knock-out B-linked genes using CRISPR/Cas9...

Plant sciences, botany

  • 2023 - 2025
    • •
  • 7 717 tis. Kč
    • •
  • 7 717 tis. Kč
    • •
  • GA ČR
Project

Discovery of promissing chemotherapeutic candidates in cyanobacteria using high-throughput screening mode of action and molecular targets. (GF21-05649K)

notably, thermal proteome profiling and genome wide CRISPR-Cas9 screening conducted high-throughput screening (HTS) of cyanobacteria-derived fraction library from......

Pharmacology and pharmacy

  • 2021 - 2024
    • •
  • 8 193 tis. Kč
    • •
  • 8 193 tis. Kč
    • •
  • GA ČR
Project

Leishmania-sand fly interaction new approaches to answer old questions (GA21-15700S)

by CRISPR-Cas9 method and evaluate the transmission to mice. We also focus on sand fly-mediated gene silencing and CRISPR-Cas9-mediated gene-editing techniques, unique among......

Zoology

  • 2021 - 2023
    • •
  • 9 864 tis. Kč
    • •
  • 9 864 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 887