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Lymphocyte subpopulatins in patients with humoral immunodeficiencies (NR7981)
T- and- B- cell surface markers, namely those known to be abnormal in patients with common variable immunodeficiency (CVID), will be analysed in patients with selective IgA deficiency, selective IgM deficiency and CVID. The results ...
FN - Epidemiologie, infekční nemoci a klinická imunologie
- 2004 - 2006 •
- 1 682 tis. Kč •
- 1 668 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2004 - 1. 1. 2006
Uznané náklady
Podpora ze státního rozpočtu (99%)
Poskytovatel: Ministerstvo zdravotnictví
Common variable immunodeficiency (CVID).The study of immunoregulatory relations and their affection by therapy (IZ4171)
The aim of the study is to find appropriate immunology laboratory tests for identification of defect of immunoregulatory mechanism in patients with cpmmon variable immunodeficiency (CVID). Assure the indication and dose levels of intravenous...
FN - Epidemiologie, infekční nemoci a klinická imunologie
- 1997 - 1999 •
- 1 290 tis. Kč •
- 1 083 tis. Kč •
- MZ
Řešení projektu: 1. 1. 1997 - 1. 1. 1999
Uznané náklady
Podpora ze státního rozpočtu (84%)
Poskytovatel: Ministerstvo zdravotnictví
Characterization of B lymphocyte subpopulations in patients with common variable immunodeficiency. (NR9198)
1. Examination, quantification and more precise immunophenotypization of transitional and immature (CD21-) B cells in patients with CVID and comparison of the found proportions with the control group. 2. Evaluation of SHM frequency in rearra...
FN - Epidemiologie, infekční nemoci a klinická imunologie
- 2007 - 2009 •
- 6 789 tis. Kč •
- 6 768 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2007 - 31. 12. 2009
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Specific postvaccination immune response against viral pathogens in immunocompromised patients (NU22-05-00402)
The response to vaccination fails in some immunocompromised patients. The aim of the project is to study seroconversion and T lymphocyte response in patients with Common Variable Immunodeficiency (CVID), in immunosuppressed lung transplant p...
Immunology
- 2022 - 2025 •
- 13 035 tis. Kč •
- 13 035 tis. Kč •
- MZ
Řešení projektu: 1. 5. 2022 - 31. 12. 2025
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Disturbances of differentiation of B-lymphocytes in patients with defects of humoral immunity (NT11414)
The Ig-specific single-cell RT-PCR in B cells of patients with CVID, IgAD/IgMD will be used to analyze somatic hypermutation, affinity maturation/isotype switch, proliferation and activation, BCR signalling and differentiation stadium of B c...
FN - Epidemiologie, infekční nemoci a klinická imunologie
- 2010 - 2014 •
- 9 894 tis. Kč •
- 9 894 tis. Kč •
- MZ
Řešení projektu: 1. 9. 2010 - 31. 12. 2014
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Fc receptors on immune cells and clinical manifestation in patients with primary immunodeficiency (NI7138)
The relation of membrane structures, particularly Fc gamma receptors to the severity of clinical manifestation and to the efficacy of gammaglobulin therapy in patients with primary immunodeficiency will be analysed in the study. A part of the study i...
FN - Epidemiologie, infekční nemoci a klinická imunologie
- 2002 - 2004 •
- 2 881 tis. Kč •
- 2 841 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2002 - 1. 1. 2004
Uznané náklady
Podpora ze státního rozpočtu (99%)
Poskytovatel: Ministerstvo zdravotnictví
Role of granulocytes and monocytes in induction and development of immunodeficiency disease and other immunopathological processes (NV15-28732A)
The project is focussed on monitoring the activation of granulocytes in patients with common variable immunodeficiency (CVID) and complement deficiency – hereditary angioedema (HAE). We will study the signs of granulocyte activation determin...
EC - Imunologie
- 2015 - 2018 •
- 11 855 tis. Kč •
- 11 098 tis. Kč •
- MZ
Řešení projektu: 1. 5. 2015 - 31. 12. 2018
Uznané náklady
Podpora ze státního rozpočtu (94%)
Poskytovatel: Ministerstvo zdravotnictví
Screening of mutations and polymorphisms in neonatal Fc receptor gene in patients with primary disorders of antibody production (NR9192)
The aim of our project is to completely map mutation and/or polymorphism spectrum in the FcRn gene in healthy subjects and in patients with primary disorders of antibody production. It will be determined whether and how a sequence variability in the ...
EB - Genetika a molekulární biologie
- 2007 - 2009 •
- 3 526 tis. Kč •
- 3 476 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2007 - 31. 12. 2009
Uznané náklady
Podpora ze státního rozpočtu (99%)
Poskytovatel: Ministerstvo zdravotnictví
Specific antibody response in patients with impaired immunity (NR9035)
The evaluation of natural antibodies and antibody production after vaccination with T-cell dependent antigens and T-cell independent antigens will be performed in defined patient groups with PID. Specific ELISA using Galalpha1-3Gal antigen will be us...
FN - Epidemiologie, infekční nemoci a klinická imunologie
- 2006 - 2009 •
- 3 593 tis. Kč •
- 3 441 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2006 - 31. 12. 2009
Uznané náklady
Podpora ze státního rozpočtu (96%)
Poskytovatel: Ministerstvo zdravotnictví
Molecular mechanisms of signaling through leukocyte receptors their role in health and disease. (GBP302/12/G101)
proteins and pathways of normal, functionally aberrant (CVID) and (pre)malignant...
EC - Imunologie
- 2012 - 2018 •
- 75 061 tis. Kč •
- 75 061 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2012 - 31. 12. 2018
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
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