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1 024 (0,115s) •

Project

Structural Determinants of Substrate Specificity of Human Cytochromes P450 (GA303/09/1001)

important Cytochromes P450 (CYPs) taking part in the metabolism of drugs. The individual formsof CYP enzymes are known to differ significantly in their ability to bind, the structural determinants governing the ability of ...

CE - Biochemie

  • 2009 - 2012
    • •
  • 2 981 tis. Kč
    • •
  • 2 981 tis. Kč
    • •
  • GA ČR
Project

Mechanism of ligand access/egress to/from active site of microsomal drug-metabolising cytochromes P450 (GPP303/12/P019)

The microsomal cytochromes P450 (CYPs) are enzymes capable of metabolizing metabolism in liver. The structure of the CYP enzyme contains buried active site the substrate specificity of the CYP enzymes<...

FR - Farmakologie a lékárnická chemie

  • 2012 - 2014
    • •
  • 976 tis. Kč
    • •
  • 976 tis. Kč
    • •
  • GA ČR
Project

Porcine enzymes of biotransformation (OC09003)

The aim of the project is to compare the properties of the main enzymes of biotransformation of foreign compounds in pig and in the man, namely, cytochromes P450 and uridindiphosphoglucuronosyltransferases (UGT). Activities of these enzy...

CE - Biochemie

  • 2009 - 2009
    • •
  • 500 tis. Kč
    • •
  • 500 tis. Kč
    • •
  • MŠMT
Project

Effect of pro- and anti-inflammatory factors on cytochrome P450 expression - modulation by natural substances (GP303/04/P074)

, and berberine, on the liver detoxification system. Cytochrome P450 (CYP) 1A2 is the focus of several drugs. Expression of this enzyme is regulated by arylhydrocarbon receptor (AhR interact directly with CYP 1A2 or affect ...

CE - Biochemie

  • 2004 - 2006
    • •
  • 672 tis. Kč
    • •
  • 672 tis. Kč
    • •
  • GA ČR
Project

Mechanism of modulation of cytochrome P450 1A1/2 mediated oxidation of drugs and carcinogens by cytochrome b5; experimental and computational approach (GA203/09/0812)

Cytochromes P450 (CYPs) represent a large and important group of enzymes oxidizing majority of drugs and carcinogens. Eukaryotic CYPs act in tight cooperation (cyt b5), was reported to enhance, inhibit, or has no effect on ...

CE - Biochemie

  • 2009 - 2011
    • •
  • 1 349 tis. Kč
    • •
  • 1 349 tis. Kč
    • •
  • GA ČR
Project

GROUP INTERACTIONS OF AZOLE PESTICIDES AND THEIR EFFECTS ON ESSENTIAL ENZYMES (GA18-01710S)

investigations of the pesticide group effects on cytochrome P450 (CYP) superfamily enzymes properties of the azole compounds, steroids, substrates of CYP enzymes, and other......

Agriculture

  • 2018 - 2021
    • •
  • 7 365 tis. Kč
    • •
  • 6 579 tis. Kč
    • •
  • GA ČR
Project

Effect of polyphenols and chelators on toxicity and effects of anthracyclines and taxanes (NL7567)

we will study effects of polyphenols and chelators on physical, chemical and biochemical interactions of doxorubin and its metabolites with Fe ions and enzymes in ROS production and lipid peroxidation and the protective effects on proteins a...

FR - Farmakologie a lékárnická chemie

  • 2003 - 2005
    • •
  • 5 395 tis. Kč
    • •
  • 2 443 tis. Kč
    • •
  • MZ
Project

The role of MAP kinases in cellular signalling of aryl hydrocarbon receptor (AhR) and glucocorticoid receptor (GR) (GP305/08/P089)

The cytochromes P450 (CYP) are involved in the biotransformation of majority of the drugs. Some of these enzymes are regulated by receptors. The function and activity of these receptors depends on covalent modification, frequently t...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 1 524 tis. Kč
    • •
  • 1 524 tis. Kč
    • •
  • GA ČR
Project

Expression of biotransformation enzymes in primary liver cancers (NV17-28231A)

The project proposed aims at studying expression of biotransformation enzymes in primary liver cancer, namely hepatocellular carcinoma (HCC). Hepatocytes constitute). It is known that enzyme expression vanishes in cultivated primary...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2017 - 2021
    • •
  • 14 965 tis. Kč
    • •
  • 14 565 tis. Kč
    • •
  • MZ
Project

Phenotype dynamics in patient treated by paroxetine regarding the clinical correlates (NF6159)

The aim of the project is to establish the role of CYP 2D6 genetic polymorphism with to the efficacy and drug safety of treatment of anxiety disorders with paroxetine and duration of metabolic phenotype conversion within treatment discontinu...

FL - Psychiatrie, sexuologie

  • 2000 - 2002
    • •
  • 1 051 tis. Kč
    • •
  • 1 051 tis. Kč
    • •
  • MZ
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