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7 (0,069s) •

Project

Cytochrome P450 active sites (OC 133)

study of compresibility and flexibility of active sites of P450 cytocromes, forms CYP2C9 and CYP3A4...

CE - Biochemie

  • 2006 - 2007
    • •
  • 1 180 tis. Kč
    • •
  • 800 tis. Kč
    • •
  • MŠMT
Project

Flexibility, Solvation, and Drug Binding of Pharmacologically Active Enzymes Cytochromes P450 (GP305/06/P139)

anticoagulant drug, is primarily metabolized by the liver microsomal CYP2C9 but in some as a result of an overdosis. A catalytically deficient allelic variant of CYP2C9, notably-warfarin side effect. Recently, the structure of huma...

FR - Farmakologie a lékárnická chemie

  • 2006 - 2008
    • •
  • 894 tis. Kč
    • •
  • 894 tis. Kč
    • •
  • GA ČR
Project

Pleiotropic effect of hypolipidemics (OC09004)

The aim of the project is to get an information whether a model fibrate (fenofibrate) is able to influence significantly the expression and activity of rat liver microsomal cytochrome P450 CYP2C11 and whether this change is also reflected in elevated...

FR - Farmakologie a lékárnická chemie

  • 2009 - 2009
    • •
  • 350 tis. Kč
    • •
  • 350 tis. Kč
    • •
  • MŠMT
Project

*Development of DNA-based diagnostic kit for therapeutic warfarin dose evaluation (FR-TI1/399)

*The cause of unexpected bleeding in warfarin treatment is its low therapeutic index and gross inter-individual dosing. Nowadays it is possible to adjust the individual dosage by genetic testing of polymorphic variability in patients. Thus the aim of...

FS - Lékařská zařízení, přístroje a vybavení

  • 2009 - 2012
    • •
  • 19 221 tis. Kč
    • •
  • 12 881 tis. Kč
    • •
  • MPO
Project

The role of MAP kinases in cellular signalling of aryl hydrocarbon receptor (AhR) and glucocorticoid receptor (GR) (GP305/08/P089)

of cytochromes P450 CYP1A1/2, CYP2B6, CYP2C9, CYP3A4 will be studied as well. In parallel...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 1 524 tis. Kč
    • •
  • 1 524 tis. Kč
    • •
  • GA ČR
Project

Structural Determinants of Substrate Specificity of Human Cytochromes P450 (GA303/09/1001)

to the drug metabolism: CYP3A4 (metabolizing the largest number of known drugs), CYP2C9...

CE - Biochemie

  • 2009 - 2012
    • •
  • 2 981 tis. Kč
    • •
  • 2 981 tis. Kč
    • •
  • GA ČR
Project

Study on tissue-specific aspects of transcriptional regulation of selected P-450 enzymes and drug transporters. (GA303/07/0128)

of CYP3A4, CYP2C9 and CYP1A1 enzymes and P-glycoprotein (MDR1) and BCRP (ABCG2...

CE - Biochemie

  • 2007 - 2011
    • •
  • 5 045 tis. Kč
    • •
  • 5 045 tis. Kč
    • •
  • GA ČR
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