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5 161 (0,096s) •

Project

Cytochrome P450 active sites (OC 133)

study of compresibility and flexibility of active sites of P450 cytocromes, forms CYP2C9 and CYP3A4...

CE - Biochemie

  • 2006 - 2007
    • •
  • 1 180 tis. Kč
    • •
  • 800 tis. Kč
    • •
  • MŠMT
Project

In vitro expression of recombinant protein CYP3A4 for study of metabolic changes of drugs feasibility study (NL6177)

The project is focussed on feasibility study of recombinant expression of CYP3A4 enzyme for in virto tests of drug biotransformation. The project is based on cloning gene for CYP3A4 into baculovirus expression vector and succesive p...

FR - Farmakologie a lékárnická chemie

  • 2000 - 2002
    • •
  • 1 117 tis. Kč
    • •
  • 1 117 tis. Kč
    • •
  • MZ
Project

Novel mechanisms of CYP3A4 enzyme regulation based on posttranslational modification of nuclear receptors - implications for pharmacotherapy (GAP303/12/0472)

CYP3A4 enzyme is the most important enzyme of drug/xenobiotic biotransformation and inducible CYP3A4 expression. However, only little is known about functional consequences of posttranslational modifications of the NRs in hepatic

FR - Farmakologie a lékárnická chemie

  • 2012 - 2016
    • •
  • 7 548 tis. Kč
    • •
  • 7 548 tis. Kč
    • •
  • GA ČR
Project

The influence of gene variability on the bioavailability of immunosuppressiv drugs and its relation to the short-term and long-term outcome of kidney transplantation (NR8816)

Observation of the influence of polymorphisms in CYP3A4, CYP3A5 and MDR-1 genes on the metabolism of immunosuppressive drugs in kidney transplant recipients. Observation of effect of polymorphisms in CYP3A4, CYP3A5 and MDR-1 genes o...

FR - Farmakologie a lékárnická chemie

  • 2006 - 2008
    • •
  • 3 375 tis. Kč
    • •
  • 3 071 tis. Kč
    • •
  • MZ
Project

Structure and function of cytochromes P450 of human and (mini)pig origin (GA203/02/1152)

orthologous human forms (CYP3A4, CYP2A6 and CYP2E 1). Spectroscopic techniques (resonanceThe project proposed is focussed on the comparison of properties (structure and function) of three cytochromes P450 of human and minipig origi...

CE - Biochemie

  • 2002 - 2004
    • •
  • 2 087 tis. Kč
    • •
  • 1 350 tis. Kč
    • •
  • GA ČR
Project

Enantiospecific interactions between clinically used chiral drugs and regulatory pathways of human cytochromes P450. (GA13-01809S)

-warfarin activates PXR and induces CYP3A4, while therapeutically more active S-warfarin is less potent CYP3A4 inducer. This implies that the use of enantiopure drugs as S......

FR - Farmakologie a lékárnická chemie

  • 2013 - 2017
    • •
  • 9 725 tis. Kč
    • •
  • 9 725 tis. Kč
    • •
  • GA ČR
Project

The role of MAP kinases in cellular signalling of aryl hydrocarbon receptor (AhR) and glucocorticoid receptor (GR) (GP305/08/P089)

of cytochromes P450 CYP1A1/2, CYP2B6, CYP2C9, CYP3A4 will be studied as well. In parallel...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 1 524 tis. Kč
    • •
  • 1 524 tis. Kč
    • •
  • GA ČR
Project

Flexibility, Solvation, and Drug Binding of Pharmacologically Active Enzymes Cytochromes P450 (GP305/06/P139)

point of view. The other studied system CYP3A4 is responsible for 50...

FR - Farmakologie a lékárnická chemie

  • 2006 - 2008
    • •
  • 894 tis. Kč
    • •
  • 894 tis. Kč
    • •
  • GA ČR
Project

Structural Determinants of Substrate Specificity of Human Cytochromes P450 (GA303/09/1001)

to the drug metabolism: CYP3A4 (metabolizing the largest number of known drugs), CYP2C9...

CE - Biochemie

  • 2009 - 2012
    • •
  • 2 981 tis. Kč
    • •
  • 2 981 tis. Kč
    • •
  • GA ČR
Project

Identification of inherited DNA polymorphisms in genes of testosterone synthetic pathway as factors of genetic predisposition to development of prostate cancer and their use in prevention and prognosis in Czech population (NR8039)

,CYP3A4, SRD5A2 and Androgen receptor gene) will be selected from public databases...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 4 906 tis. Kč
    • •
  • 4 618 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 5 161