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3 582 (0,134s) •

Project

Calcium binding proteins - biological markers of colon mucosa malignant (GA310/98/P238)

with a large number of calcium-binding proteins. One of their most important functions proteins.The S100 calcium-binding proteins recently became of major interest because. The aim of this projec...

EC - Imunologie

  • 1998 - 1999
    • •
  • 270 tis. Kč
    • •
  • 270 tis. Kč
    • •
  • GA ČR
Project

Non-canonical role of ameloblastin in regulation of homeostasis in structural tissues and its potential clinical application (GJ19-19025Y)

Ameloblastin belongs to closely related family of secretory calcium-binding phosphoprotein (SCPP) genes. Important common feature is ability to bind Ca2+ and phosphate ions and their intrinsically disordered structure. Amel...

Cell biology

  • 2019 - 2023
    • •
  • 7 874 tis. Kč
    • •
  • 7 874 tis. Kč
    • •
  • GA ČR
Project

The role of calcium and 14-3-3 protein in the regulation of human ubiquitin ligase Nedd4-2 (GA23-04686S)

of the regulation of human Nedd4-2 ubiquitin ligase through Ca2+ and 14-3-3 proteins. Nedd4-2 activity of Nedd4-2, which further requires binding of the C2 domain to the membrane to stabilize the active conformation of Nedd4-2. In ...

Biochemical research methods

  • 2023 - 2025
    • •
  • 12 583 tis. Kč
    • •
  • 12 388 tis. Kč
    • •
  • GA ČR
Project

Mechanisms of membrane interaction and cytotoxic activity of adenylate cyclase (IAA5020406)

the principles of membrane interactions of proteins. We will tie-up on identification in binding of ACT to the CD11b integrin receptor will be defined and the oligomeric in calcium mobilizationinto cells will be determined...

CE - Biochemie

  • 2004 - 2008
    • •
  • 6 250 tis. Kč
    • •
  • 5 910 tis. Kč
    • •
  • AV ČR
Project

Biological activity of the Neisseria meningitidis RTX protein FrpC (GA310/06/0720)

a family of FrpC-like RTX proteins of unknown role in meningococcal lifestyle. We have recently shown that FrpC can bind a variety of host cell types and undergoes a unique calcium-dependent autoprocessing at an internal A...

EE - Mikrobiologie, virologie

  • 2006 - 2008
    • •
  • 4 901 tis. Kč
    • •
  • 4 901 tis. Kč
    • •
  • GA ČR
Project

Regulation of muscle phenotype under normal, experimental and pathological conditions (GA304/08/0256)

In Europe over 300.000 patients suffer from muscular diseases and specific muscle genes and extrinsic factors play a significant role in differentiation of normal and aberrant muscle characteristics. Our model of heterochronous iso-transplantation en...

EA - Morfologické obory a cytologie

  • 2008 - 2012
    • •
  • 4 345 tis. Kč
    • •
  • 4 345 tis. Kč
    • •
  • GA ČR
Project

Modeling activation of human calcium release-activated channels. (GJ19-20728Y)

Calcium ions are primarily used by cells as messenger. From cell birth by regulating gene transcription or protein synthesis, to cellular death where rise in calcium ion levels onset apoptosis mechanisms. CRAC is a prot...

Physical chemistry

  • 2019 - 2021
    • •
  • 3 479 tis. Kč
    • •
  • 3 479 tis. Kč
    • •
  • GA ČR
Project

Desensitization and ATP binding site of purinergic P2X receptors (IAA5011408)

of the receptor form the ligand-binding site and how do they function. In the proposed project and molecular structure of ATP binding site. Experiments will be done with several native of phosphorylation-dephosphorylation cycle, in...

ED - Fyziologie

  • 2004 - 2008
    • •
  • 3 278 tis. Kč
    • •
  • 3 278 tis. Kč
    • •
  • AV ČR
Project

Calcium signaling in neonatal rat gonadotrophs (IAA5011105)

receptor coupled to G protein which stimulates oscillatory calcium release fromIntracellular calcium plays an important role in regulation of many cellular ofextracellular calcium. In the proposed project we sould...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 2 917 tis. Kč
    • •
  • 848 tis. Kč
    • •
  • AV ČR
Project

Understanding different aspects of structure and function of cation translocation systems. (LTC17069)

3D structural models of all human Orai family members; most probable multimeric state of the humanOrai channel; amino-acids regulating gating; quantification of Ca2+ binding to the unique, extracellular accumulating region CAR; divergent arc...

BO - Biofyzika

  • 2017 - 2019
    • •
  • 2 083 tis. Kč
    • •
  • 2 083 tis. Kč
    • •
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