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1 439 (0,093s) •

Project

The development of chimeric antigen receptors for the immunotherapy of lymphoma. (NT14030)

antigens which could be targeted by CAR. We will prepare novel CAR's to these antigens...

FD - Onkologie a hematologie

  • 2013 - 2015
    • •
  • 7 435 tis. Kč
    • •
  • 7 435 tis. Kč
    • •
  • MZ
Project

Pre-clinical validation of cGMP production of CAR T-cells for solid tumorstherapy (NV19-08-00147)

Chimeric antigen receptor (CAR) T-cell is a cutting edge technology for targeted cell therapy of oncologic diseases. Promising clinical results were reported for hematological malignancies, but the results in solid tumors a...

Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)

  • 2019 - 2023
    • •
  • 14 420 tis. Kč
    • •
  • 14 420 tis. Kč
    • •
  • MZ
Project

Genetically modified donor T cells as a universal cell source for the immunotherapy of tumors using T lymphocytes equipped with a chimeric antigen receptor (CAR) (FV40145)

a chimeric antigen receptor (CAR) on their surface that will detect specific cell surface...

Oncology

  • 2019 - 2022
    • •
  • 15 604 tis. Kč
    • •
  • 10 922 tis. Kč
    • •
  • MPO
Project

New approaches to Chimeric Antigen Receptor T cells analysis of RASAL3 protein function and identification of novel CAR-T activity-modifying genes (GA22-35273S)

Chimeric Antigen Receptor (CAR) T cells achieved remarkable success in treating B-cell malignancies, yet, their long term efficiency does not hold up to the original promises. Novel designs of CAR-T cells are urgently neede...

Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)

  • 2022 - 2024
    • •
  • 8 916 tis. Kč
    • •
  • 8 814 tis. Kč
    • •
  • GA ČR
Project

Synthetic multiepitopic vaccine agains boreliosis intended for veterinary applications (TA01011165)

Development of technology for production, purification and stabilisation of subtypes of recombinant chimeric multiepitopic antigens OspC, OspA, DbpA derived from Borelia burgdorferi. Synthesis of glycolipid antigen (acylate...

FP - Ostatní lékařské obory

  • 2011 - 2014
    • •
  • 30 472 tis. Kč
    • •
  • 23 463 tis. Kč
    • •
  • TA ČR
Project

Adoptive immunotherapy of hematological malignancies in elderly patients preclinical and clinical study (NV16-34405A)

genetically modified in order to express chimeric antigen receptors targeting suitable AML...

FD - Onkologie a hematologie

  • 2016 - 2019
    • •
  • 10 994 tis. Kč
    • •
  • 10 994 tis. Kč
    • •
  • MZ
Project

Functional Properties of Chimeric and Natural Acetylcholine Receptors (GA305/93/0591)

ED - Fyziologie

  • 1993 - 1995
    • •
  • 6 tis. Kč
    • •
  • 12 tis. Kč
    • •
  • GA ČR
Project

Advanced Immunomonitoring and Immunotherapy of Hematological and Hemato-oncological Patients (EF16_025/0007428)

The development of diagnostic methods for determination of immunosuppressive escape mechanisms of leukemic cells, that should serve for the selection of a appropriate personalized immunotherapy of hemato- oncological patients, Development of procedur...

Immunology

  • 2018 - 2022
    • •
  • 101 850 tis. Kč
    • •
  • 24 545 tis. Kč
    • •
  • MŠMT
Project

CAR-iNKT cells for the treatment of multiple myeloma (NW24-03-00079)

is used within the framework of the use of an artificially prepared CAR (Chimeric-Antigen-Receptor) receptor, which is expressed on genetically manipulated of treatment ensuring a longer or complete cure. Plasma c...

Hematology

  • 2024 - 2027
    • •
  • 10 663 tis. Kč
    • •
  • 10 663 tis. Kč
    • •
  • MZ
Project

Development of highly effective allogenic CAR T-cells based on innovative surface proteome analysis and non-viral approaches (NW25-03-00298)

Cell therapies based on chimeric antigen receptor (CAR) T-cells represent a modern, highly promising direction in the treatment of cancer. In this project we receptors (hTCR) targeting the newly found antigens<...

Cell biology

  • 2025 - 2028
    • •
  • 16 192 tis. Kč
    • •
  • 16 192 tis. Kč
    • •
  • MZ
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