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1 099 (0,097s) •

Project

The role of non-canonical Wnt signaling in molecular pathogenesis of chronic lymphocytic leukemia (NT11217)

The proposed project attempts to clarify the role of non-canonical Wnt pathway in diagnosis, prognosis and in molecular pathogenesis of chronic lymphocytic leukemia (CLL). The proposed goal will be achieved by expression an...

FD - Onkologie a hematologie

  • 2010 - 2014
    • •
  • 9 860 tis. Kč
    • •
  • 9 860 tis. Kč
    • •
  • MZ
Project

Mutational status of IgVH genes in chronic lymphocytic leukemia (NM7604)

Introducing examination of the mutational status of IgVH genes will help the clinicians in therapeutic decision in patients with CLL. The results of the mutational status of IgVH genes and their prognostic significance will be correlated with other p...

EB - Genetika a molekulární biologie

  • 2003 - 2005
    • •
  • 1 885 tis. Kč
    • •
  • 1 798 tis. Kč
    • •
  • MZ
Project

molecular cytogenetic diagnosis of chronic lymphocytic leukemias /CLL/. (NC5010)

Detection of structural and numerical chromosomal changes(trisomy12,dell13q and 17p)in patiens with chronic lymphocytic leukemia.Determine specifity of these changes and evaluate diagnostic and prognoszic value of molecular catogene...

FD - Onkologie a hematologie

  • 1998 - 2000
    • •
  • 2 440 tis. Kč
    • •
  • 1 958 tis. Kč
    • •
  • MZ
Project

Analysis of changes in genome and its expression in chronic lymphocytic leukemia patients during the disease development (NS10439)

Many genetic factors contribute to clinical heterogeneity of chronic lymphocytic leukemia, with some of them already serving as prognostic markers. Genetic changes proceeding in the genome of CLL cells during the disease co...

FD - Onkologie a hematologie

  • 2009 - 2011
    • •
  • 4 362 tis. Kč
    • •
  • 4 362 tis. Kč
    • •
  • MZ
Project

Influence of Toll-like Receptor Agonists on Immunogenicity of Tumour Cells in B cell Chronic Lymphocytic Leukemia (GP310/08/P353)

B-chronic lymphocytic leukemia (B-CLL) is most frequent leukemia in adult age incurable with conventional therapy. B-CLL tumour cells are weakly immunogenic which may contribute to disease progression and inhibit e...

EC - Imunologie

  • 2008 - 2010
    • •
  • 1 230 tis. Kč
    • •
  • 1 230 tis. Kč
    • •
  • GA ČR
Project

NON-CODING RNAS IN MICROENVIRONMENTAL INTERACTIONS OF B CELL CHRONIC LYMPHOCYTIC LEUKEMIA (GX25-15368X)

dysregulated in “mature” B cell neoplasms. Chronic lymphocytic leukemia (CLL), the most frequent leukemia in adults, depends on largely unclear mechanisms (dys)regulatingIt has been shown that short non-coding RNA...

Cell biology

  • 2025 - 2029
    • •
  • 49 937 tis. Kč
    • •
  • 49 937 tis. Kč
    • •
  • GA ČR
Project

Analysis of clonal heterogeneity in chronic lymphocytic leukemia using next generation sequencing of B cell receptor. A national study. (NV15-30015A)

Chronic lymphocytic leukemia (CLL) is characterized by extraordinary heterogeneity concerning clinical presentation and molecular features. As the clonal disease of B lymphocytes, each case can be described by a sp...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 15 351 tis. Kč
    • •
  • 15 028 tis. Kč
    • •
  • MZ
Project

Analysis of WNT/PCP pathway for better management of chronic lymphocytic leukemia (NV15-29793A)

Chronic lymphocytic leukemia (CLL) is the most common leukemia among adults in the Czech Republic. The recent data from our laboratories suggest that one of the crucial molecular pathways associated with pathogenes...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 9 937 tis. Kč
    • •
  • 9 937 tis. Kč
    • •
  • MZ
Project

Preclinical development of new highly selective CK1 inhibitors for the treatment of selected oncological diseases (FW06010481)

, especially chronic lymphocytic leukemia (CLL), lymphomas, solid tumors and possibly other. The second indication that substances may be targeted is acute myeloid leukemia (AML......

Pharmacology and pharmacy

  • 2023 - 2025
    • •
  • 20 862 tis. Kč
    • •
  • 14 275 tis. Kč
    • •
  • TA ČR
Project

Significance of molecular-cytogenetic analyses in chronic lamphocytic leukemia (NC6470)

To follow by methods of molecular cytogenetics specific chromosomal delections and trisomies in chronic lymphocytic leukemia. To divide the patients into the groups according to cytogenetic, immunophetypic and clinical find...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 1 267 tis. Kč
    • •
  • 1 264 tis. Kč
    • •
  • MZ
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