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5 717 (0,14s) •

Project

Study of cryptic chromosomal regions involved into complex translocations in acute leukem. and myelodysplastic syndrome by multicolour fluoresc. in situ hybridisation (M-FISH). (NE6188)

Using M-FISH to the identification of complex chromosomal changes and complex translocations in childhood and adult acute myeloid leukaemias,acute lymphoblastic leukaemias. Detrmination of prognostic and terapeutic signific...

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 3 120 tis. Kč
    • •
  • 3 112 tis. Kč
    • •
  • MZ
Project

Uncoupling of DNA restriction and DNA translocation functions of EcoR124I restriction-modification enzyme - a potential melecular motor (GA204/03/1011)

The ability of type I restriction-modification enzyme to translocate DNA experience with the complex enzyme EcoR124I existing in bacterial cell in equilibrium of R1M2S1andR2M2S1 complexes. Complex with only one Hsd...

EE - Mikrobiologie, virologie

  • 2003 - 2005
    • •
  • 2 153 tis. Kč
    • •
  • 2 153 tis. Kč
    • •
  • GA ČR
Project

Pathogenic role of autoantigens tissue transglutaminase and calreticulin in coeliac disease (ME 416)

. Autoantigens will be isolated and their localization and translocation in cells studied in study of localisation and translocation of autoantigens. In case of membrane expression the membrane complexes containing autoanti...

EC - Imunologie

  • 2001 - 2003
    • •
  • 442 tis. Kč
    • •
  • 200 tis. Kč
    • •
  • MŠMT
Project

Identification of amino acid residues of the HsdS and HsdR subunits required for correct assembly of Type I restriction-modification enzyme EcoR124I (GA204/07/0325)

- hydrolysis and subsequentDNA translocation. Since the HsdS is the only odd subunit in the multisubunit complex, the opportunity exists to use HsdS assembly mutants for asymmetric with HsdS assembly mutants to produce stable R1-

EB - Genetika a molekulární biologie

  • 2007 - 2010
    • •
  • 4 165 tis. Kč
    • •
  • 4 165 tis. Kč
    • •
  • GA ČR
Project

Allosteric communication in membrane protein complexes linked to conformational transitions on multiple timescales (GJ20-11563Y)

translocation in the Sec complex using a combination of single-molecule and in silicoAllosterically modulated molecular machines mediate many of the key processes in all forms of life. The Sec translocon, a membrane bound protein <...

Biophysics

  • 2020 - 2022
    • •
  • 4 713 tis. Kč
    • •
  • 4 713 tis. Kč
    • •
  • GA ČR
Project

Study of meiotic disturbances in men - carriers of congenital balanced translocations and their effect on the outcome of assisted reproduction (NS9842)

Presence of a congenital balanced translocation in the karyotype is a common of an affected child depends on the type of translocation. Statistical evaluation segregation of translocated chromosomes and their normal homolog...

EB - Genetika a molekulární biologie

  • 2008 - 2011
    • •
  • 4 951 tis. Kč
    • •
  • 4 297 tis. Kč
    • •
  • MZ
Project

The study of pathogenesis and clinical importance of MLL gene rearrangements in acute leukemias (AL) (NR7849)

Molecular cytogenetics, molecular genetics and translocation biochip in determination chromosomal translocations involving the MLL gene. Determination of novel MLL-fusion partners in patients with new, undescribed translocations...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 3 863 tis. Kč
    • •
  • 3 333 tis. Kč
    • •
  • MZ
Project

Water holding and translocation via mycorrhizal networks (GA23-05461S)

Albeit arbuscular mycorrhizal fungi (AMF) are an inherent component of soils, we only start to disentangle complex relationships involved in interaction translocation. We plan to explore the role of AMF in water holding capacity of ...

Plant sciences, botany

  • 2023 - 2025
    • •
  • 10 467 tis. Kč
    • •
  • 10 467 tis. Kč
    • •
  • GA ČR
Project

Probiotics and intestinal bacterial translocation in liver cirrhosis. (NK7366)

translocation plays an important role in etiopathogenesis of this condition. Probiotics can have favourable efect on bacterial translocation by influencing bacterial of experimental part of our study is study of bacterial trans...

FE - Ostatní obory vnitřního lékařství

  • 2003 - 2005
    • •
  • 2 016 tis. Kč
    • •
  • 1 917 tis. Kč
    • •
  • MZ
Project

Towards atomistic understanding of the first moments in the life of protein (GA23-05557S)

called protein N-terminus, translocates through the tunnel is rather sparse complex in shape, dynamics, electrostatics, solvation, etc. The project goal the tunnel. Using computer simulations and molecular modelling, the transl...

Biophysics

  • 2023 - 2025
    • •
  • 3 883 tis. Kč
    • •
  • 3 883 tis. Kč
    • •
  • GA ČR
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