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235 (0,071s) •

Project

Toxic effects of nanomaterials as a function of their structure and physicochemical properties (LD14002)

the cytotoxicity of selected well characterized nanomaterials (NM) ussing matematical modelling and standardized protocols for cytotoxicity measurement in human lung cell lines A549 and BEAS to predict cytotoxicity with th...

DN - Vliv životního prostředí na zdraví

  • 2014 - 2016
    • •
  • 2 440 tis. Kč
    • •
  • 2 081 tis. Kč
    • •
  • MŠMT
Project

Tumor stress-induced proteins as target structures for cytotoxic cells (IAA5020403)

During the recent period, a number of new findings has been obtained about an alternative pathway for activation of cytotoxic cells that is dependent on the recognition of stress-induced proteins at tumor cell surface. In the current proposa...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2004 - 2008
    • •
  • 4 917 tis. Kč
    • •
  • 4 917 tis. Kč
    • •
  • AV ČR
Project

Involvement of apoptotic mechanism(s) in natural killer (NK), T cell cytotoxicity (IAA7020602)

Cytotoxic lymphocytes are believed to be crucial for the efficient immunological control of the organism. Several recent studies have strongly implicated two pathways in target-cell damage by cytotoxic lymphocytes. Beside secretory ...

EB - Genetika a molekulární biologie

  • 1996 - 1998
    • •
  • 1 686 tis. Kč
    • •
  • 1 301 tis. Kč
    • •
  • AV ČR
Project

Toxic potential, evolution of toxin synthesis, and factors driving anatoxin-a production in benthic and soil nostocacean cyanobacteria (GA14-18067S)

and ageing process, will be studied on the example of anatoxin-a. Unknown cytotoxic compounds will be detected by means of testing of cytotoxic activity to mammal cells. Selected cytotoxic secondary metabolites will be iso...

EH - Ekologie – společenstva

  • 2014 - 2016
    • •
  • 9 072 tis. Kč
    • •
  • 9 072 tis. Kč
    • •
  • GA ČR
Project

Cytotoxicity and induction of apoptosis in mammal cells by cyanobacterial secondary metabolites (GPP503/12/P614)

metabolite mixtures is needed. In proposed project cytotoxicity of crude cyanobacterial of cyanobacterial cytotoxicity. In second part of the project induction of apoptosis......

EE - Mikrobiologie, virologie

  • 2012 - 2014
    • •
  • 3 171 tis. Kč
    • •
  • 3 171 tis. Kč
    • •
  • GA ČR
Project

The influence of adenosine receptors on NK cells mediated antitumor immunity response. (KJB500200614)

NK cells, due to their ability of direct cytotoxic function, represent an important part of antitumor immune response. NK cells express, besides others, adenosine ? relased by tumors as local suppresive mechanism, inhibiting cytotoxic

EC - Imunologie

  • 2006 - 2008
    • •
  • 845 tis. Kč
    • •
  • 845 tis. Kč
    • •
  • AV ČR
Project

Biosafety of materials applied as internal equipment of new projected ambulance (7AMB13PL034)

The aim of the study 1. Detection of antibacterial and anticorrosive properties 2. Detection of cytotoxicity of prepared materials 3. Evaluation of adhesive and anti-inflammatory properties 4. Preparation different modification of surface us...

FS - Lékařská zařízení, přístroje a vybavení

  • 2013 - 2014
    • •
  • 70 tis. Kč
    • •
  • 70 tis. Kč
    • •
  • MŠMT
Project

Generation of highly cytotoxic cells and their possible role in immunotherapy (PL18)

FM - Hygiena

  • 1991 - 1994
    • •
  • 0 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • MZ
Project

Anticancer active coordination compounds with multimodal effect (GA21-19060S)

systems. In the physiological environment, the compounds transform into two cytotoxic for their in vitro cytotoxicity on a panel of human cancerous and non-malignant cells. Mechanistic aspects of cytotoxicity will be studi...

Medicinal chemistry

  • 2021 - 2024
    • •
  • 7 875 tis. Kč
    • •
  • 6 975 tis. Kč
    • •
  • GA ČR
Project

Mechanisms of Target Cell Recognition with Cytotoxic Cells and their Relationship to the Mode of Activation (IA52052)

9G - 9

  • 1992 - 1994
    • •
  • 0 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • AV ČR
  • 1 - 10 out of 235