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1 780 (0,208s) •

Project

Applications of chemical structural probes and electroanalytical methods in DNA damage detection. Development of DNA sensors. (KJB4004302)

In this project we propose to employ chemical probing of DNA structure, in connection with biochemical methods and electrochemical detection, in analysis of DNA damage. Monitoring of DNA-damaging pollutants in the environme...

CG - Elektrochemie

  • 2003 - 2005
    • •
  • 2 052 tis. Kč
    • •
  • 1 212 tis. Kč
    • •
  • AV ČR
Project

Translesion DNA synthesis across lesions induced by agents of biological significance. An insight into energetics, kinetics and mechanism (GA17-09436S)

The biological effects of DNA-damaging physical and chemical agents are associated with their ability to affect DNA replication. The main objective of DNA due to its damage by DNA-damaging agents is an important fa...

BO - Biofyzika

  • 2017 - 2019
    • •
  • 5 627 tis. Kč
    • •
  • 5 006 tis. Kč
    • •
  • GA ČR
Project

Interactions of wild type and mutant p53 proteins with damaged DNA and their roles in cellular response to anticancer chemotherapy (IAA500040701)

Interactions of tumor suppressor protein p53 with DNA are crucial for its-specific DNA binding, but also ability of both wt and mutant (mut) p53 to recognize DNA and mut p53 interactions with damaged DNA, particula...

EB - Genetika a molekulární biologie

  • 2007 - 2010
    • •
  • 4 824 tis. Kč
    • •
  • 4 824 tis. Kč
    • •
  • AV ČR
Project

Development of electrochemical biodetectors for DNA damage (IAA4004108)

electrochemical biodetector (biosensor) for DNA damage (both in vitro and in cells) and DNA damaging agents. A procedure developed in our laboratory which allows to detect DNA strand breaks using mercury electrodes modifie...

CG - Elektrochemie

  • 2001 - 2003
    • •
  • 1 758 tis. Kč
    • •
  • 804 tis. Kč
    • •
  • AV ČR
Project

Extrachromosomal circular DNA and its impact on the evolution of plant satellite DNA (GP204/06/P360)

Satellite DNA formed by long arrays of repetitive tandemly arranged nucleotide recombination between repetitive units leading to formation of circular satellite DNA could extrachromosomal circular DNA with special impact on...

EB - Genetika a molekulární biologie

  • 2006 - 2008
    • •
  • 947 tis. Kč
    • •
  • 947 tis. Kč
    • •
  • GA ČR
Project

Triplex-forming DNA and its interactions with p53 proteins (GP204/06/P369)

Structure-selective DNA recognition is an important characteristic of not only). It is supposed that, besides its sequence, DNA conformation is crucial for p53-DNA and mutp53 with DNA containing sequences that adop...

EB - Genetika a molekulární biologie

  • 2006 - 2008
    • •
  • 1 197 tis. Kč
    • •
  • 1 197 tis. Kč
    • •
  • GA ČR
Project

Induction of DNA damage in cancer cells by targeting alternative DNA structures by specific ligands. Relationship with their anticancer activity. (GA24-10213S)

(non-B DNA) DNA structures in human cancer cells by specific ligands can induce genome instability, DNA damage, and eventually cell death. We have collected several which prefer, according to our results, binding to altern...

Biochemistry and molecular biology

  • 2024 - 2026
    • •
  • 6 000 tis. Kč
    • •
  • 5 970 tis. Kč
    • •
  • GA ČR
Project

Tolerance and bypass of DNA damage by metal-based anticancer drugs (GA203/06/1239)

This project proposes to examine the effect of DNA conformation on the catalytic efficiency and fidelity of DNA-dependent DNA and RNA polymerases on DNA. In addition, the methodology based on the use of DNA

FR - Farmakologie a lékárnická chemie

  • 2006 - 2008
    • •
  • 2 865 tis. Kč
    • •
  • 2 865 tis. Kč
    • •
  • GA ČR
Project

Targeting DNA interactions with platinum anticancer drugs with damaged-DNA binding-proteins (LH13096)

, in partucular on factors affecting interactions of DNA modified by these metallodrugs with damaged-DNA binding-proteins. The major motivation for formulation of this aim the methods of molecular biophysics, biology and pharmacolog...

CA - Anorganická chemie

  • 2013 - 2015
    • •
  • 1 866 tis. Kč
    • •
  • 1 866 tis. Kč
    • •
  • MŠMT
Project

DNA Adducts determination among the persons occupationally and environmentally exposed to alkenes. (IZ3157)

FM - Hygiena

  • 1995 - 1997
    • •
  • 966 tis. Kč
    • •
  • 966 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 1 780