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14 133 (0,109s) •

Project

Radiolytic damage of DNA bases (KJB4048401)

Oxidative damage of DNA bases belongs to the most severe DNA damages caused is to establish differences in reactivity of free DNA bases and bases within double stranded DNA. The effect of...

CE - Biochemie

  • 2004 - 2005
    • •
  • 278 tis. Kč
    • •
  • 278 tis. Kč
    • •
  • AV ČR
Project

Tolerance and bypass of DNA damage by metal-based anticancer drugs (GA203/06/1239)

underlying resistance to metal-based drugs and their antitumor and mutagenic affects. In addition, the methodology based on the use of DNA and RNA polymerases and DNA templatesThis project proposes to examine the ...

FR - Farmakologie a lékárnická chemie

  • 2006 - 2008
    • •
  • 2 865 tis. Kč
    • •
  • 2 865 tis. Kč
    • •
  • GA ČR
Project

DNA Base Interactions and Structure of DNA. (GA203/94/1490)

CE - Biochemie

  • 1994 - 1996
    • •
  • 242 tis. Kč
    • •
  • 362 tis. Kč
    • •
  • GA ČR
Project

Structure and dynamics of DNA. Advanced computational studies. (GAP208/11/1822)

unique B-DNA base pair steps, using conformational scans, experimental geometries and geometries derived by simulations, with the aim to understand relation between base stacking and B-DNA local conformational var...

CF - Fyzikální chemie a teoretická chemie

  • 2011 - 2015
    • •
  • 4 129 tis. Kč
    • •
  • 4 129 tis. Kč
    • •
  • GA ČR
Project

Electrochemical biosensors for the detection of DNA damaging agents (GA204/98/P091)

, changes in electrochemical (redox) signals of DNA bases (mainly guanine) measuredThis project is based on the application of electrodes modified with nucleic acids in studies of DNA structure and interactions, in...

CE - Biochemie

  • 1998 - 2000
    • •
  • 503 tis. Kč
    • •
  • 442 tis. Kč
    • •
  • GA ČR
Project

Metal-mediated base pairs; the modification of DNA for future nano-electronics (GA18-14990S)

of properties of metallo-DNA molecules utilisable for design of molecular devices such as molecular wire. The metallo-DNAs will include metal-mediated base pairs T-Hg-T and C-Ag in normal DNA base pairs. ...

Biophysics

  • 2018 - 2023
    • •
  • 2 518 tis. Kč
    • •
  • 2 315 tis. Kč
    • •
  • GA ČR
Project

Structure and dynamics of DNA (GA203/97/0029)

. Structureand dynamics of the DNA bases, and their hydrogen bonded and stacked pairsThe aim of the project is to understand structural flexibility of the DNA to rationalize the internal dynamics of the bases so th...

CF - Fyzikální chemie a teoretická chemie

  • 1997 - 1999
    • •
  • 3 941 tis. Kč
    • •
  • 2 018 tis. Kč
    • •
  • GA ČR
Project

Influence of chemical modification of DNA and synthetic oligonucleotides on their electrochemical behaviour (GA204/00/D049)

Knowledge about influence of chemical modification of DNA and synthetic oligonucleotides on their electrochemical behaviour are important for construction of the sensors for specific interactions of DNA (include DNA hybridi...

CE - Biochemie

  • 2000 - 2003
    • •
  • 1 231 tis. Kč
    • •
  • 719 tis. Kč
    • •
  • GA ČR
Project

Genetically modified polymerases and their use for amplification of unpurified DNA (FR-TI3/067)

used tool for a variety of analytical and diagnostic applications based on amplification of DNA (or cDNA) fragments. However, qPCR has its limitations, especially when difficult-to-amplify templates are used (e.g. GC-rich DNA

CE - Biochemie

  • 2011 - 2014
    • •
  • 5 600 tis. Kč
    • •
  • 4 400 tis. Kč
    • •
  • MPO
Project

Targeted damage of the DNA repair mechanisms as a tool for cancer therapy (NV15-31604A)

The project is focused on the study of base excision repair (BER) at both enzymes with the model DNA duplexes modified in critical sites with the structurally impairment of base excision repair. The project is designed wit...

EB - Genetika a molekulární biologie

  • 2015 - 2018
    • •
  • 17 562 tis. Kč
    • •
  • 17 562 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 14 133