All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”
EN
ČeštinaEnglish

Filters

2 538 (0,147s) •

Project

Role of DNA conformation and DNA grooves in protein - DNA recognition. Model studies. (GA204/96/0287)

governing the specific and selective binding of proteins to DNA with a special regard of the complex. Peptides modelling the specific protein binding sites (i.e. the binding motif of the bZIP proteins), and also m...

CE - Biochemie

  • 1996 - 1998
    • •
  • 747 tis. Kč
    • •
  • 480 tis. Kč
    • •
  • GA ČR
Project

Mutants of tumor supressor protein p53 and regulation of thei DNA binding activity (KJB500040502)

and/or acrylamide gel. We will examine the possibility of activation p53 mutants to DNA binding to DNA damage by regulating the expression of genes involved in controlling DNA p53 mutant binding propertie...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 1 230 tis. Kč
    • •
  • 1 230 tis. Kč
    • •
  • AV ČR
Project

Targeting DNA interactions with platinum anticancer drugs with damaged-DNA binding-proteins (LH13096)

with damaged-DNA binding-proteins. The major motivation for formulation of this aim the methods of molecular biophysics, biology and pharmacology: (1) Novel DNA binding modes modified by polynuclear platinum compo...

CA - Anorganická chemie

  • 2013 - 2015
    • •
  • 1 866 tis. Kč
    • •
  • 1 866 tis. Kč
    • •
  • MŠMT
Project

Influence of DNA superhelicity on sequence specific and structure selective binding of the p53 protein (GP301/04/P025)

play crucial role in p53 protein function. DNA protein binding is often p53 binding to sets of topoisomeric samples and compare with p53 binding to DNA to study binding of the p53 protein to thes...

CE - Biochemie

  • 2004 - 2006
    • •
  • 720 tis. Kč
    • •
  • 720 tis. Kč
    • •
  • GA ČR
Project

Binding of tumor suppressor protein p53 to DNA. Effect of DNA supercoling and protein postsynthetic modification (IAA4004110)

protein p53 and its binding to DNA. Better understanding of this key protein binding to DNA and particularly to supercoiled DNA, (ii) the effect ofthe DNA superhelix density on p53 binding

CE - Biochemie

  • 2001 - 2004
    • •
  • 4 874 tis. Kč
    • •
  • 1 990 tis. Kč
    • •
  • AV ČR
Project

Regulation of transcription factors binding to consensus sequences in superhelical DNA. Influence of phosphorylation of tumor supressor proteins (IAB5004203)

for semiquantitative testing of the effect of the DNA supercoiling on protein binding and technique assay for testing DNA binding status of p53 protein isolated directly from malignantWe propose systematic studies...

EB - Genetika a molekulární biologie

  • 2002 - 2004
    • •
  • 3 400 tis. Kč
    • •
  • 1 080 tis. Kč
    • •
  • AV ČR
Project

Understanding of binding of RNA polymerace I transcription factor xUBF to DNA (IAA5004105)

Xenopus upstream binding factor (UBF) is an RNA polymerase I-specific transcription factor of ribosomal genes, containing five DNA binding domains (HMG box) which are exxential to promote transcription of tibosomal genes. T...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 4 181 tis. Kč
    • •
  • 1 373 tis. Kč
    • •
  • AV ČR
Project

Interactions of wild type and mutant p53 proteins with damaged DNA and their roles in cellular response to anticancer chemotherapy (IAA500040701)

-specific DNA binding, but also ability of both wt and mutant (mut) p53 to recognize DNA binding, and (3) influence of genotoxic substances on mut p53 binding to genomic DNA of genotoxic agents on...

EB - Genetika a molekulární biologie

  • 2007 - 2010
    • •
  • 4 824 tis. Kč
    • •
  • 4 824 tis. Kč
    • •
  • AV ČR
Project

Study of the interactions between forkhead transcription factor AFX and DNA. (LZ1K03020)

and association with 14-3-3 proteins. FOXO transcription factors specifically bind DNA number of structures describing interactions between DNA-binding domainand DNAis of interactions between FOXO DNA-

CE - Biochemie

  • 2003 - 2005
    • •
  • 1 321 tis. Kč
    • •
  • 1 152 tis. Kč
    • •
  • MŠMT
Project

Interactions of tumor suppressor proteins with DNA. Roles of DNA conformation and protein modifications (GA204/02/0734)

The ability of tumor suppressor protein p53 to bind to specific DNA sequences and to certain types of DNA conformational motifs are crucial for its function in regulating and recombination. Loss of the p53 DNA ...

CE - Biochemie

  • 2002 - 2004
    • •
  • 4 448 tis. Kč
    • •
  • 3 042 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 2 538