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5 766 (0,206s) •

Project

Stress response to DNA damage in colorectal carcinogenesis. (GA15-14789S)

Stress response to DNA damage, suboptimal DNA repair and altered programmed cell death contribute to increased cancer risk. Moreover, modulations in DNA repair differences between cell types influence the ...

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 6 965 tis. Kč
    • •
  • 6 965 tis. Kč
    • •
  • GA ČR
Project

The p53 response to DNA damage and disruption of its regulation in cancer cells. (NC4783)

An examination of the cellular response to DNA damage and the induction of p53 in human tumours with particular reference to melanoma.......

FD - Onkologie a hematologie

  • 1998 - 2000
    • •
  • 6 553 tis. Kč
    • •
  • 6 378 tis. Kč
    • •
  • MZ
Project

Role of R2TP complex in DNA damage response and cell proliferation (GA14-34264S)

ATM, ATR and DNA-PKcs kinases are key regulators of DNA damage response several cell cycle and DNA damage response proteins and confirmed direct phospho stabilization by R2TP complex in <...

EB - Genetika a molekulární biologie

  • 2014 - 2018
    • •
  • 6 165 tis. Kč
    • •
  • 6 165 tis. Kč
    • •
  • GA ČR
Project

Post-translational modifications of Daxx and their functional relevance in DNA damage response and cellular senescence (GPP305/11/P683)

in the cellular response to DNA-damaging agents and to investigate whether the level of Daxx, exploring the role of Daxx in DNA damage response and cellular senescence is of great, cellular senes...

EB - Genetika a molekulární biologie

  • 2011 - 2014
    • •
  • 2 199 tis. Kč
    • •
  • 2 199 tis. Kč
    • •
  • GA ČR
Project

From DNA damage to a cell cycle block ? plant specific signalling mechanisms (LH12145)

The aim of the project is to characterize DNA damage response and its the topic throughout the entire plant kingdom. Coordination of DNA damage response are to: 1) characterize the evolutionary or...

EF - Botanika

  • 2012 - 2014
    • •
  • 2 737 tis. Kč
    • •
  • 2 737 tis. Kč
    • •
  • MŠMT
Project

Modulation of poly-ADP-ribosylation in DNA damage response and targeted treatment (GPP301/11/P554)

DNA damage response pathways mediated by signaling via poly-ADP-ribosylation. Possible aberrations in the alternative DNA repair pathway through non-homologous end to radiation, as a way to identify novel componen...

EB - Genetika a molekulární biologie

  • 2011 - 2013
    • •
  • 2 190 tis. Kč
    • •
  • 2 190 tis. Kč
    • •
  • GA ČR
Project

Role of gamma- tubulin in the coordination of microtubule nucleation and cell division with the DNA damage response pathway in plants (GA15-11657S)

in Arabidopsis and discovered key regulators in DNA damage response (e.g. ATM, WEE1 the function of gamma-tubulin interactions with DNA damage response proteins us to suggest that gamma-tubulin p...

EB - Genetika a molekulární biologie

  • 2015 - 2019
    • •
  • 5 557 tis. Kč
    • •
  • 5 557 tis. Kč
    • •
  • GA ČR
Project

Studies on DNA damage and apoptosis by genotoxic stress (ME 534)

Genotoxic treatment induces in plants DNA damage and various defence mechanisms to repair or eliminate damaged cells. By expression profiling of selected genes and detection of DNA integrity by Comet Assay we want ...

EB - Genetika a molekulární biologie

  • 2002 - 2004
    • •
  • 2 639 tis. Kč
    • •
  • 633 tis. Kč
    • •
  • MŠMT
Project

Protein modifications in DNA damage signalling Mechanisms and cancer relevance (GA301/08/0353)

role of protein phosphorylation in DNA damage response (DDR) is well established that guards against genetic diseases including cancer. Orchestration of DNA damage signaling with cell cycle checkpoints, <...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 5 659 tis. Kč
    • •
  • 5 659 tis. Kč
    • •
  • GA ČR
Project

Dynamics of DNA damage response in cells (GA13-18392S)

by activation a conserved DNA damage response pathway (DDR) that triggers cell cycle arrest and DNA repair. At organismal level, DDR acts as a barrier preventing progression FRET-based biosensor that monitors the ...

EB - Genetika a molekulární biologie

  • 2013 - 2018
    • •
  • 9 395 tis. Kč
    • •
  • 9 395 tis. Kč
    • •
  • GA ČR
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