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7 636 (0,153s) •

Project

Protein modifications in DNA damage signalling Mechanisms and cancer relevance (GA301/08/0353)

role of protein phosphorylation in DNA damage response (DDR) is well established that guards against genetic diseases including cancer. Orchestration of DNA damage signaling with cell cycle checkpoints, <...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 5 659 tis. Kč
    • •
  • 5 659 tis. Kč
    • •
  • GA ČR
Project

Studies on DNA damage and apoptosis by genotoxic stress (ME 534)

Genotoxic treatment induces in plants DNA damage and various defence mechanisms to repair or eliminate damaged cells. By expression profiling of selected genes and detection of DNA integrity by Comet Assay...

EB - Genetika a molekulární biologie

  • 2002 - 2004
    • •
  • 2 639 tis. Kč
    • •
  • 633 tis. Kč
    • •
  • MŠMT
Project

Stress response to DNA damage in colorectal carcinogenesis. (GA15-14789S)

Stress response to DNA damage, suboptimal DNA repair and altered programmed cell death contribute to increased cancer risk. Moreover, modulations in DNA repair differences between cell types influence the ...

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 6 965 tis. Kč
    • •
  • 6 965 tis. Kč
    • •
  • GA ČR
Project

The DNA Damage Response and RNA Processing in Neurological Disorders (GA25-15199S)

processing with the cellular DNA damage response. By unravelling the complex relationship mutations, with particular emphasis on their roles in RNA processing and the DNA damage, and given the prevalence ...

Cell biology

  • 2025 - 2027
    • •
  • 11 910 tis. Kč
    • •
  • 11 910 tis. Kč
    • •
  • GA ČR
Project

The role of p53, p73 and IRF-1 proteins in regulation of the cell response do DNA damage (GA312/99/1550)

, and in the regulation of the cells response to DNA damage. Our major interest is to study the regulation of the p53 function in different types of tumours after DNA damage as well pathways status after i...

FD - Onkologie a hematologie

  • 1999 - 2001
    • •
  • 3 298 tis. Kč
    • •
  • 3 298 tis. Kč
    • •
  • GA ČR
Project

The role of plant systemic acquired resistance (SAR) in response to genotoxic stress (GA521/01/1418)

The aim of this project is to show by measurement of DNA damage and of gene expression that genotoxic stress is a part of systemic acquired resistance (SAR). From the adaptive and cross-adaptive effect of treatment with hyd...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 4 099 tis. Kč
    • •
  • 1 826 tis. Kč
    • •
  • GA ČR
Project

Changes in DNA repair system associated with therapy outcome of ovarian carcinoma. (GA19-10543S)

repair, mutations in homologous recombination DNA repair genes BRCA1,RAD51C/D the chemotherapy outcomes is based on the induction of apoptosis via DNA damage. Examples response is not investigated. The pr...

Human genetics

  • 2019 - 2022
    • •
  • 9 841 tis. Kč
    • •
  • 9 661 tis. Kč
    • •
  • GA ČR
Project

The p53 response to DNA damage and disruption of its regulation in cancer cells. (NC4783)

An examination of the cellular response to DNA damage and the induction of p53 in human tumours with particular reference to melanoma.......

FD - Onkologie a hematologie

  • 1998 - 2000
    • •
  • 6 553 tis. Kč
    • •
  • 6 378 tis. Kč
    • •
  • MZ
Project

Role of R2TP complex in DNA damage response and cell proliferation (GA14-34264S)

ATM, ATR and DNA-PKcs kinases are key regulators of DNA damage response several cell cycle and DNA damage response proteins and confirmed direct phospho stabilization by R2TP complex in <...

EB - Genetika a molekulární biologie

  • 2014 - 2018
    • •
  • 6 165 tis. Kč
    • •
  • 6 165 tis. Kč
    • •
  • GA ČR
Project

Exploring non-canonical ORFs with functions in DNA damage repair (EH22_010/0008995)

The number of annotated genes has not changed significantly since the sequencing of the human genome 20 years ago. However, recent technological advances have revealed that our genome's protein-coding capacity is greater than previously thoug...

Genetics and heredity (medical genetics to be 3)

  • 2025 - 2028
    • •
  • 3 904 tis. Kč
    • •
  • 988 tis. Kč
    • •
  • MŠMT
  • 1 - 10 out of 7 636