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2 109 (0,107s) •

Project

DNA labeling with redox markers for electrochemical sensing. Applications in analysis of nucleotide sequences and molecular diagnostics (IAA400040901)

The aim of this project is the development of novel techniques of DNA labeling and their utilization in DNA electrochemical analysis and biosensor design. The DNA labeling) their incorporation to DNA

CG - Elektrochemie

  • 2009 - 2013
    • •
  • 9 985 tis. Kč
    • •
  • 9 985 tis. Kč
    • •
  • AV ČR
Project

Electroactive and fluorescent modifications of nucleic acids for structure & interaction studies and for applications in diagnostics (GA22-11252S)

and interactions with electrode surfaces; (4) studies involving fluorescently labelled DNA, new findings on electrocatalytic processes, establishing techniques of DNA labeling) substantially expanded potentialiti...

Analytical chemistry

  • 2022 - 2024
    • •
  • 11 476 tis. Kč
    • •
  • 11 215 tis. Kč
    • •
  • GA ČR
Project

Sequence-specific electrochemical sensing of PCR-amplified genomic DNA fragments (GPP206/11/P739)

of an internal nucleotide sequence of a PCR product with DNA probes followed by label-freeSeveral principles of electrochemical DNA sensing coupled to PCR amplification of specific DNA sequences were reported. Des...

CG - Elektrochemie

  • 2011 - 2015
    • •
  • 1 376 tis. Kč
    • •
  • 1 376 tis. Kč
    • •
  • GA ČR
Project

Electron and proton transfer in ionized DNA fragments (LTAUSA19094)

of two interrelated specific aims. Aim one is syntheses of isotopically labeled oligonucleotides as model systems for the study of electron and proton transfer in DNA radicals. Specifically isotopically labeled oligonucleo...

Analytical chemistry

  • 2020 - 2022
    • •
  • 4 376 tis. Kč
    • •
  • 3 581 tis. Kč
    • •
  • MŠMT
Project

Azaphthalocyanines – dark quenchers in DNA hybridization probes (GA17-19094S)

for DNA hybridization assays in double-labeled probes. The AzaPc quenchers to enable labeling of oligodeoxynucleotide (ODN) probes in selected positions (including intrastrand labeling) by either click chemistry o...

CC - Organická chemie

  • 2017 - 2021
    • •
  • 5 890 tis. Kč
    • •
  • 5 890 tis. Kč
    • •
  • GA ČR
Project

Conjugates of nucleobases with metal complexes as electroactive markers. Application of labelled oligonucleotides in electrochemical DNA sensors (GA203/05/0043)

of bipyridine or phenanthroline etc.) connected by a conjugated linker. Such labelled synthesis. We will study electrochemical behaviour of the labelled oligonucleotides of sensors for DNA hybridization. We suppose that ef...

CC - Organická chemie

  • 2005 - 2007
    • •
  • 2 967 tis. Kč
    • •
  • 2 967 tis. Kč
    • •
  • GA ČR
Project

Electrochemical detectros of DNA hybridization and their applications in DNA diagnostics (IAA4004402)

labeling of probes or target DNAs, signal amplification by enzyme tags, and suitable procedures of sample pretreatment. Testing of these methods with "real" target DNA in the field of electrochemical DNA sensors f...

CG - Elektrochemie

  • 2004 - 2007
    • •
  • 2 028 tis. Kč
    • •
  • 2 028 tis. Kč
    • •
  • AV ČR
Project

Observing single-molecule pirouettes (GA25-16414S)

such as enzymatic unwinding of DNA, the displacements of the involved molecules are subtle to enable rotational tracking of a molecule either unlabeled or with a rotation label based on DNA origami and plasmonic nanopartic...

Optics (including laser optics and quantum optics)

  • 2025 - 2028
    • •
  • 5 994 tis. Kč
    • •
  • 5 994 tis. Kč
    • •
  • GA ČR
Project

The idtroduction of comparative genomic hybridization in chidhood ALL to detection and study of clinical importance of genetic changes. (IZ4026)

The introducing of the method of CGH,used in the detect. of chromosom. aberrations in childhood ALL.The differentially labeled tumor and control DNA fluorochr.The ratios of fliorescence intensities generated by tumor and normal ...

FG - Pediatrie

  • 1997 - 1999
    • •
  • 1 904 tis. Kč
    • •
  • 1 904 tis. Kč
    • •
  • MZ
Project

Application of molecular and computer controlled methods for the diagnostics of gametes disorders and impairment of the genetic apparatus in farm animals. (EP0960006094)

" will be applied, using fluorescently labelled DNA probes for the detection of anuploidy in a herd of farm animals. In situ hybridization using fluorescently labelled painting DNA probes will be used for testing t...

GI - Šlechtění a plemenářství hospodářských zvířat

  • 1996 - 2000
    • •
  • 2 989 tis. Kč
    • •
  • 2 989 tis. Kč
    • •
  • MZe
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