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1 780 (0,127s) •

Project

Impact of methylation pattern on multiple myeloma progression (NV18-03-00500)

mechanisms, such as DNA methylation are increasingly recognized as potent modulators to the diagnostics, the contribution of DNA methylation has been discovered as important. Specifically, we investigate the impact of DNA ...

Genetics and heredity (medical genetics to be 3)

  • 2018 - 2021
    • •
  • 11 170 tis. Kč
    • •
  • 11 170 tis. Kč
    • •
  • MZ
Project

The molecular markers in diagnostics and therapy-monitoring of myelodysplastic syndrome patients treated by new modalities. (NV16-27790A)

Myelodysplastic syndrome (MDS) is a clonal disorder of hematopoiesis characterized by ineffective hematopoiesis and increased risk of transformation to acute myeloid leukemia (AML). In MDS, the somatic mutations were recently found to precede MDS pat...

FD - Onkologie a hematologie

  • 2016 - 2019
    • •
  • 12 498 tis. Kč
    • •
  • 12 498 tis. Kč
    • •
  • MZ
Project

A promotor methylation of TSGs associated with HPV-driven carcinogenesis as a screening tool for anal carcinoma at risk population - validation study (NV17-31777A)

is not among the highly sensitive nor specific methods of investigation. DNA methylation of cervical cancer. This research should therefore validate DNA methylation as a potential......

EB - Genetika a molekulární biologie

  • 2017 - 2021
    • •
  • 8 456 tis. Kč
    • •
  • 8 152 tis. Kč
    • •
  • MZ
Project

Use of molecular regulatory mechanisms as biomarkers of prognosis and efficacy of cytostatic therapy in ovarian cancer (NW25J-03-00103)

(lncRNAs) and DNA methylation are important regulatory mechanisms that play a pivotal chemotherapy. The aim of the project is to determine the lncRNA - DNA methylation - mRNA......

Human genetics

  • 2025 - 2028
    • •
  • 6 631 tis. Kč
    • •
  • 6 631 tis. Kč
    • •
  • MZ
Project

New diagnostic and prognostic markers in pre- and post-operative management of patients with thyroid cancer (NU21-01-00448)

Thyroid tumors are the most frequent endocrine malignancy. Molecular genetic markers help in diagnostics, prognosis and determination of the risk of malignancy in fine needle aspiration biopsies (FNAB), where pre- and postoperative patient managemen...

Endocrinology and metabolism (including diabetes, hormones)

  • 2021 - 2025
    • •
  • 17 121 tis. Kč
    • •
  • 16 737 tis. Kč
    • •
  • MZ
Project

Transcriptomics and DNA methylation analysis in patients with focal cortical dysplasia (NU21-04-00305)

, both on the level of regulatory RNAs and on the level of DNA methylation. The study...

Neurosciences (including psychophysiology)

  • 2021 - 2025
    • •
  • 15 329 tis. Kč
    • •
  • 15 259 tis. Kč
    • •
  • MZ
Project

Applications of chemical structural probes and electroanalytical methods in DNA damage detection. Development of DNA sensors. (KJB4004302)

In this project we propose to employ chemical probing of DNA structure, in connection with biochemical methods and electrochemical detection, in analysis of DNA damage. Monitoring of DNA-damaging pollutants in the environme...

CG - Elektrochemie

  • 2003 - 2005
    • •
  • 2 052 tis. Kč
    • •
  • 1 212 tis. Kč
    • •
  • AV ČR
Project

Translesion DNA synthesis across lesions induced by agents of biological significance. An insight into energetics, kinetics and mechanism (GA17-09436S)

The biological effects of DNA-damaging physical and chemical agents are associated with their ability to affect DNA replication. The main objective of DNA due to its damage by DNA-damaging agents is an important fa...

BO - Biofyzika

  • 2017 - 2019
    • •
  • 5 627 tis. Kč
    • •
  • 5 006 tis. Kč
    • •
  • GA ČR
Project

Interactions of wild type and mutant p53 proteins with damaged DNA and their roles in cellular response to anticancer chemotherapy (IAA500040701)

Interactions of tumor suppressor protein p53 with DNA are crucial for its-specific DNA binding, but also ability of both wt and mutant (mut) p53 to recognize DNA and mut p53 interactions with damaged DNA, particula...

EB - Genetika a molekulární biologie

  • 2007 - 2010
    • •
  • 4 824 tis. Kč
    • •
  • 4 824 tis. Kč
    • •
  • AV ČR
Project

Development of electrochemical biodetectors for DNA damage (IAA4004108)

electrochemical biodetector (biosensor) for DNA damage (both in vitro and in cells) and DNA damaging agents. A procedure developed in our laboratory which allows to detect DNA strand breaks using mercury electrodes modifie...

CG - Elektrochemie

  • 2001 - 2003
    • •
  • 1 758 tis. Kč
    • •
  • 804 tis. Kč
    • •
  • AV ČR
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