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9 210 (0,174s) •

Project

Radiation damage to DNA protein complexes (1P05OC085)

assessment of partner bond and their damage in specific complex DNA-protein after irradiation by ionisating radiation...

BO - Biofyzika

  • 2005 - 2007
    • •
  • 2 320 tis. Kč
    • •
  • 981 tis. Kč
    • •
  • MŠMT
Project

Platinum Metal Complexes as DNA-Protein Cross-Linking Agents (ME08017)

This project is aimed to find out data on covalent interactions of DNA modified by platinum complexes with proteins....

BO - Biofyzika

  • 2008 - 2010
    • •
  • 2 226 tis. Kč
    • •
  • 2 226 tis. Kč
    • •
  • MŠMT
Project

Binuclear metal complexes as DNA-protein cross-linking agents (GA301/00/0556)

of dinuclear metal complexes to form specific DNA-protein cross-links. This goal, slower Ternary Complex DNA-Pt-Pt-Protein formation. The potential for the use of dinuclear metal complexes

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 3 255 tis. Kč
    • •
  • 2 823 tis. Kč
    • •
  • GA ČR
Project

Radiation induced damage of DNA - protein complexes (IAA1048103)

and excitations of DNA and protein). The choice of DNA-protein complexes depends on:iThe project includes theoretical simulation of radiation attack to DNA-protein complexes. Ou...

BO - Biofyzika

  • 2001 - 2003
    • •
  • 1 543 tis. Kč
    • •
  • 738 tis. Kč
    • •
  • AV ČR
Project

Role of R2TP complex in DNA damage response and cell proliferation (GA14-34264S)

assembly of large protein complexes. We are currently describing R2TP complex component several cell cycle and DNA damage response proteins and confirmed direct phospho stabilization by R2TP complex

EB - Genetika a molekulární biologie

  • 2014 - 2018
    • •
  • 6 165 tis. Kč
    • •
  • 6 165 tis. Kč
    • •
  • GA ČR
Project

Protein-DNA Complexes and Force Field Development (GA20-28231S)

The aim of this proposal is to explore protein-DNA interactions hand in hand and we have indications that these problems may propagate to protein-DNA interactions. Because systematic studies of FF description of

Physical chemistry

  • 2020 - 2022
    • •
  • 2 687 tis. Kč
    • •
  • 2 687 tis. Kč
    • •
  • GA ČR
Project

Isolation and identification of proteins in cancer cell extracts that bind to DNA modified by antitumor metallodrugs (GPP305/10/P143)

coordination complexes arises from their ability to damage DNA, with adducts formed being various types of cross-links. Binding of antitumor metallodrugs to DNA causes. Fundamentally different modification of DNA ...

EB - Genetika a molekulární biologie

  • 2010 - 2010
    • •
  • 415 tis. Kč
    • •
  • 415 tis. Kč
    • •
  • GA ČR
Project

Interactions of organometallic antitumor compounds with nucleic acids and proteins study of sequence and substrate selectivity (GAP208/12/0622)

a binding to DNA as a key step of their antitumor activity. It leads to a modification of DNA structure and changes of its interactions with proteins. We will focus on the binding of the following complexes to

CF - Fyzikální chemie a teoretická chemie

  • 2012 - 2015
    • •
  • 5 435 tis. Kč
    • •
  • 5 435 tis. Kč
    • •
  • GA ČR
Project

Role of Nse proteins, subunits of the SMC5/6 complex, in stabilization and processing of stalled replication forks (GA13-00774S)

/4 subcomplex. The Nse3 protein structure analysis suggested presence of a DNA binds to DNA. We will use human and yeast proteins to determine affinity of the Nse1/3/4 complexes to different DNA s...

CE - Biochemie

  • 2013 - 2016
    • •
  • 7 346 tis. Kč
    • •
  • 7 346 tis. Kč
    • •
  • GA ČR
Project

Influence of conformation motifs and epigenetic modifications to DNA binding properties of p53 family proteins (GA15-21855S)

modifications and local DNA structures (cruciform, triplexes and quadruplexes) on protein-DNA interaction. We will pursue a systematic study of the complexes between DNA understand how protein-

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 6 795 tis. Kč
    • •
  • 6 795 tis. Kč
    • •
  • GA ČR
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