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2 075 (0,097s) •

Project

Changes in DNA repair system associated with therapy outcome of ovarian carcinoma. (GA19-10543S)

mortality among female cancers. The deficiencies in DNA repair pathways (DNA mismatch repair, mutations in homologous recombination DNA repair genes BRCA1,RAD51C/D) predispose the OvC onset. Tod...

Human genetics

  • 2019 - 2022
    • •
  • 9 841 tis. Kč
    • •
  • 9 661 tis. Kč
    • •
  • GA ČR
Project

Structural characterisation of the interplay between transcription and DNA repair (GM21-10464M)

The interplay between DNA repair and transcription is a complex and poorly to efficiently initiate DNA repair. As the in vivo methods are inherently unable to uncover the causal relationships between DNA <...

Biochemistry and molecular biology

  • 2021 - 2025
    • •
  • 24 991 tis. Kč
    • •
  • 24 991 tis. Kč
    • •
  • GA ČR
Project

The determination of expression levels of DNA repair and cell cycle genes in peripheral blood lymphocytes in styrene exposed individuals. (IAA500390806)

, expression levels in DNA repair (XRCC1, XPC) and cell cycle genes (p53, p21, bax, bcl2 between the base excision repair phenotypes and expression of relevant DNA repair (pathways repairing styre...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 2 509 tis. Kč
    • •
  • 2 509 tis. Kč
    • •
  • AV ČR
Project

Molecular DNA repair characteristics in CRC tumor tissue (GAP304/12/1585)

-risk variants with environmental factors. DNA is constantly exposed to both endo- or exogenous DNA damaging agents. DNA repair machinery removes DNA damage and maintains components. Molecular markers of <...

EB - Genetika a molekulární biologie

  • 2012 - 2015
    • •
  • 13 871 tis. Kč
    • •
  • 13 871 tis. Kč
    • •
  • GA ČR
Project

DNA repair and sporadic colorectal cancer. (GAP304/10/1286)

significant side effects. In this context, the DNA repair system acts as a first-line. This proposal aims at: A) the assessment of DNA repair markers in patients with sporadicform of CRC at the time of the diagnos...

EB - Genetika a molekulární biologie

  • 2010 - 2013
    • •
  • 7 780 tis. Kč
    • •
  • 7 780 tis. Kč
    • •
  • GA ČR
Project

The role of post-translational modification in DNA repair and recombination Meiosis, SUMOylation and Zip3 protein (ME10048)

The goal of the project is to understand the function of SUMO protein in the homologous recombination, which is the essential process for meiosis and error-free DNA repair of double-strand breaks.......

CE - Biochemie

  • 2010 - 2012
    • •
  • 1 632 tis. Kč
    • •
  • 1 632 tis. Kč
    • •
  • MŠMT
Project

Inducible DNA repair in Arabidopsis thaliana (IAA6038201)

Plants protect integrity of their DNA against genotoxic factors by efficient DNA repair. Recently we have shown that the phenomenon of clastogenic (chromosome damage) adaptation to mutagenic treatment depends on thebaseexci...

EB - Genetika a molekulární biologie

  • 2002 - 2005
    • •
  • 3 765 tis. Kč
    • •
  • 1 814 tis. Kč
    • •
  • AV ČR
Project

Recognition and repair of DNA damage by antitumor platinum drugs.Relations to the development of new anticancer drugs. (NL6058)

and distribution of unrepaired DNA lesions in cancer cells.Dna repair is likely: Recognitionof platinum-DNA adducts by human nucleotide excision repair (NER) depends on their ability to destabilize DNA do...

FR - Farmakologie a lékárnická chemie

  • 2000 - 2002
    • •
  • 2 180 tis. Kč
    • •
  • 2 180 tis. Kč
    • •
  • MZ
Project

Genes involved in XME, DNA repair and cell cycle and their role in predicting risk of laryngeal cancer (NR9423)

analysis of genetic polymorphisms in xenobiotic metabolising enzymes genes, DNA repair genes and cell-cycle genes in PBL of patients and control subjects analysis of molecular epidemiologic parameters of laryngeal cancer gene expres...

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 6 260 tis. Kč
    • •
  • 5 908 tis. Kč
    • •
  • MZ
Project

Genetic profile of biotransformation and DNA repair genes in cancer patients from the Czech Republic. (NR8563)

Evaluation of links between individual genetic background - evaluation of polymorphisms in both DNA repair and XME genes and expression levels in lymphocytes in cancer patients and healthy controls in Czech Republic. Determination o...

EB - Genetika a molekulární biologie

  • 2005 - 2009
    • •
  • 9 468 tis. Kč
    • •
  • 6 102 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 2 075