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1 828 (0,087s) •

Project

Dynamic structure and function of the cell nucleus associated with DNA breaks (GP204/06/P349)

Double-strand DNA breaks (dsb) induced by ionizing radiation represent a serious damage of the genome, which can lead to neoplastic transformation if not repaired properly. Disclosure of dsb-reparation mechanisms is therefore very i...

EB - Genetika a molekulární biologie

  • 2006 - 2008
    • •
  • 1 086 tis. Kč
    • •
  • 1 086 tis. Kč
    • •
  • GA ČR
Project

Apoptosis induction by low-dose-rate gamma radiation in vitro (GA202/01/0016)

It is generally accepted that accumulation of cells in G1 and G2 cell-cycle phase after high-dose-rate irradiation occurs to prevent replication of damaged DNA and ensures a time for DNA reparation or apoptosis initialisati...

BO - Biofyzika

  • 2001 - 2003
    • •
  • 2 225 tis. Kč
    • •
  • 1 524 tis. Kč
    • •
  • GA ČR
Project

Potential interference of toxic properties of sulphur mustard (OVUOFVZ200810)

. The influence of of PARP inhibitors on the DNA repair (repair of cross-links) induced by SM will be studied in detail in mammalian and human cells. Both normal and DNA repair deficient on the cytostatic effect of SM. The oxidativ...

FP - Ostatní lékařské obory

  • 2008 - 2011
    • •
  • 1 889 tis. Kč
    • •
  • 1 331 tis. Kč
    • •
  • MO
Project

Archiv of Central commission for restitution and reparation (RB14/7/00)

Methodize the Archive Fond od Restituion and Reparation Commission with documentary study...

AF - Dokumentace, knihovnictví, práce s informacemi

  • 2000 - 2002
    • •
  • 336 tis. Kč
    • •
  • 336 tis. Kč
    • •
  • MZV
Project

Repair of metal and composite armors (OFVVU20130003)

The goals of the project are following: 1) Proposal of field reparation of military vehicles armour to ensures the original protection capability. 2) Realization and prove of material and technological solutions of the armour reparation<...

JG - Hutnictví, kovové materiály

  • 2013 - 2015
    • •
  • 13 229 tis. Kč
    • •
  • 13 229 tis. Kč
    • •
  • MO
Project

UP-Drábek Typing of degraded DNA of Sambucus nigra and Vitis vinifera using molecular genetics methods (1K04104)

. This project aims to detect wine adulteration using molecular genetics methods. DNA attempts were so far unsuccessful. The goal of this project is to detect DNA of wine) in wine. We want to use steps of a) DNA co-precipit...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 2 359 tis. Kč
    • •
  • 1 977 tis. Kč
    • •
  • MŠMT
Project

Chromatin environment induced by genotoxic agents (GJ19-11880Y)

DNA damage induces chromatin reorganisation which is necessary to bring to the close proximity DNA damage sites and DNA repair machineries for efficient DNA repair. What is the molecular flux of nucleosomes, indivi...

Plant sciences, botany

  • 2019 - 2022
    • •
  • 6 878 tis. Kč
    • •
  • 6 878 tis. Kč
    • •
  • GA ČR
Project

The influence of antioxidants on toxic and carcinogenic effect of cadmium (GA305/02/1231)

and the apoptosis. The blockade of apoptosis and reparative processes of DNA may be oneMetals, similarly as other xenobiotics, generate oxidative stress in the organism resulting in serious diseases. It includes also DNA d...

FR - Farmakologie a lékárnická chemie

  • 2002 - 2004
    • •
  • 2 304 tis. Kč
    • •
  • 1 884 tis. Kč
    • •
  • GA ČR
Project

Integrative analysis of genomic changes in DNA repair systems in myelodysplastic syndrome and their relevance in the pathogenesis (NV16-33485A)

number of mutations detected recently may be related to a decreased function of DNA in 84 genes involved in DNA repair mechanisms at the level of genome, transcriptome and proteome, and reparative cell activity using in vi...

FD - Onkologie a hematologie

  • 2016 - 2020
    • •
  • 9 206 tis. Kč
    • •
  • 8 995 tis. Kč
    • •
  • MZ
Project

Low-temperature reparations of the turbines creep resistance casted components (FV10510)

) is to create methodological procedures focused on the low-temperature reparations there is to find such reparations procedures which ensure the serviceability of these devices under the standard regime. Reparations will b...

JE - Nejaderná energetika, spotřeba a užití energie

  • 2016 - 2017
    • •
  • 7 884 tis. Kč
    • •
  • 5 018 tis. Kč
    • •
  • MPO
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