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1 941 (0,28s) •

Project

Regulation of DNA replication - roles of PARP1 and p53 (GJ20-03457Y)

Replication of chromosomal DNA is a fundamental process that requires stringent of origins are main means that allow replication of entire chromosomal DNA. Speed and PARP1. Considering the importance of DNA

Biochemistry and molecular biology

  • 2020 - 2022
    • •
  • 7 962 tis. Kč
    • •
  • 7 962 tis. Kč
    • •
  • GA ČR
Project

Deciphering Origins of DNA replication in genome integrity (GM22-20303M)

DNA replication is fundamental to cell proliferation, but its malfunctions can cause genome instability and trigger diseases including cancer. DNA replication assembly with proper DNA replication ...

Cell biology

  • 2022 - 2026
    • •
  • 24 928 tis. Kč
    • •
  • 24 928 tis. Kč
    • •
  • GA ČR
Project

Spatial and temporal characterization of DNA replication in phylogeneticaly related plant species with contrasting genome sizes (GA17-14048S)

DNA replication is a fundamental process required for growth and development of all eukaryotes. Genetic information is replicated during S phase of cell cycle, there are differences between plants and animals. Unfortunately...

EB - Genetika a molekulární biologie

  • 2017 - 2021
    • •
  • 5 198 tis. Kč
    • •
  • 4 463 tis. Kč
    • •
  • GA ČR
Project

Role of RECQ5 DNA helicase in maintenance of genomic stability (GA204/09/0565)

DNA replication forks often pause upon encounter of DNA damage in the DNA template. This situation can lead to DNA double-strand breaks and uncontrolled. Cells possess efficient DNA repair systems...

EB - Genetika a molekulární biologie

  • 2009 - 2013
    • •
  • 8 570 tis. Kč
    • •
  • 8 570 tis. Kč
    • •
  • GA ČR
Project

Replication of mammalian genome ? 4D view (KJB500390701)

Eucaryotic DNA replication ensures accurate and efficient genome duplication. Although a lot of findings about DNA replication is known, many questions about to the protein Cdc45 and its role in elongation step of ...

EA - Morfologické obory a cytologie

  • 2007 - 2009
    • •
  • 1 710 tis. Kč
    • •
  • 1 710 tis. Kč
    • •
  • AV ČR
Project

High-resolution spatio-temporal control of the activation mechanism of DNA replication (GC13-12317J)

Several partial mechanisms of DNA replication are to a certain depth established with many replication factors being identified. But a synthetic view and activating DNA replication. Using batteries of mode...

EA - Morfologické obory a cytologie

  • 2013 - 2016
    • •
  • 8 578 tis. Kč
    • •
  • 8 578 tis. Kč
    • •
  • GA ČR
Project

Identification and characterization of proteins involved in G-quadruplex and R-loop metabolism and their relationship with DNA replication (GX21-22593X)

DNA replication is an essential and one of the most complex processes in the cell. Not only exogenous DNA damage but also intrinsic DNA structures including G. It becomes apparent that maintenance of processive

Biochemistry and molecular biology

  • 2021 - 2025
    • •
  • 49 901 tis. Kč
    • •
  • 49 901 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms involved in reactivation of replication forks stalled by co-transcriptional R-loops (GA22-08294S)

of semiconservative DNA replication mediated by RECQ1 and RECQ5 helicases, MUS81-EME1 endonucleaseTranscription-replication conflicts (TRCs) associated with the formation of co-transcriptional RNA:DNA hybrids, termed R-loo...

Biochemistry and molecular biology

  • 2022 - 2024
    • •
  • 9 986 tis. Kč
    • •
  • 9 986 tis. Kč
    • •
  • GA ČR
Project

Exploring mechanisms of DNA replication restart upon collisions between transcription and replication complexes (GA19-07674S)

Transcription-replication collisions (TRCs) represent a significant source of genomic instability in cells experiencing DNA replication stress. Although, understanding of how a replication fork restarts DNA

Biochemistry and molecular biology

  • 2019 - 2023
    • •
  • 10 396 tis. Kč
    • •
  • 9 563 tis. Kč
    • •
  • GA ČR
Project

Role of DNA clamp complexes in the maintenance of genome stability in Arabidopsis (GA25-15186S)

The PCNA and 9-1-1 DNA clamps serve as processivity factors for the replicative DNA Polymerases and as scaffolds for proteins involved in replication, chromatin modifications, and DNA damage repair. The te...

Plant sciences, botany

  • 2025 - 2027
    • •
  • 9 975 tis. Kč
    • •
  • 9 975 tis. Kč
    • •
  • GA ČR
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