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11 844 (0,081s) •

Project

Induction of DNA damage in cancer cells by targeting alternative DNA structures by specific ligands. Relationship with their anticancer activity. (GA24-10213S)

(non-B DNA) DNA structures in human cancer cells by specific ligands can induce which prefer, according to our results, binding to alternative DNA structures over DNA-binding properties due to th...

Biochemistry and molecular biology

  • 2024 - 2026
    • •
  • 6 000 tis. Kč
    • •
  • 5 970 tis. Kč
    • •
  • GA ČR
Project

DNA structure in solution and at electrode surfaces electrochemical methods as potent tools for the analysis of DNA structure and interactions. (GA16-01625S)

in studies of DNA structure and interactions, particularly in studies and applications involving structural changes of double-helical DNA, DNA damage and hybridization of alternative DNA stru...

CG - Elektrochemie

  • 2016 - 2019
    • •
  • 4 476 tis. Kč
    • •
  • 4 281 tis. Kč
    • •
  • GA ČR
Project

Triplex-forming DNA and its interactions with p53 proteins (GP204/06/P369)

Structure-selective DNA recognition is an important characteristic of not only and mutp53 with DNA containing sequences that adopt intramolecular triplex structures in superhelical DNA (scDNA). Interaction...

EB - Genetika a molekulární biologie

  • 2006 - 2008
    • •
  • 1 197 tis. Kč
    • •
  • 1 197 tis. Kč
    • •
  • GA ČR
Project

Structure and dynamics of DNA (GA203/97/0029)

The aim of the project is to understand structural flexibility of the DNA, vibrational dynamics, and analyses of the crystallographic structural databases. Structureand dynamics of the DNA bases, and their hydrogen...

CF - Fyzikální chemie a teoretická chemie

  • 1997 - 1999
    • •
  • 3 941 tis. Kč
    • •
  • 2 018 tis. Kč
    • •
  • GA ČR
Project

In vitro and in silico identification of non-canonical DNA structures in genomic DNA sequences (GA204/08/1560)

Genomic sequencing generated an increased interest in non-coding DNA. This applies also to non-canonical DNA structures and their possible biological functions of biologically important DNA structures in g...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 2 647 tis. Kč
    • •
  • 2 647 tis. Kč
    • •
  • GA ČR
Project

Mechanical properties of RNA and DNA structural building blocks (GA17-14683S)

Natural and artificial RNA and DNA structures are composed of recurrent of cytosine methylation on DNA mechanics, and DNA with structural lesions. In the RNA field, we will focus on important structura...

BO - Biofyzika

  • 2017 - 2021
    • •
  • 4 017 tis. Kč
    • •
  • 3 756 tis. Kč
    • •
  • GA ČR
Project

Local DNA structures and their role in mutant p53 protein function in human tumours (GA22-21903S)

binding and/or recognition of local DNA structures (cruciforms, triplexes non-B DNA structures. Most missense p53 mutant proteins show reduced sequence. Differences in mutant p53 binding to structured

Oncology

  • 2022 - 2024
    • •
  • 7 056 tis. Kč
    • •
  • 7 056 tis. Kč
    • •
  • GA ČR
Project

Structural characterisation of the interplay between transcription and DNA repair (GM21-10464M)

The interplay between DNA repair and transcription is a complex and poorly understood. On one hand, transcription is one of the mayor sources of DNA damage to efficiently initiate DNA repair. As the in vivo methods are inhe...

Biochemistry and molecular biology

  • 2021 - 2025
    • •
  • 24 991 tis. Kč
    • •
  • 24 991 tis. Kč
    • •
  • GA ČR
Project

Applications of chemical structural probes and electroanalytical methods in DNA damage detection. Development of DNA sensors. (KJB4004302)

In this project we propose to employ chemical probing of DNA structure, in connection with biochemical methods and electrochemical detection, in analysis of DNA damage. Monitoring of DNA-damaging pollutants in the ...

CG - Elektrochemie

  • 2003 - 2005
    • •
  • 2 052 tis. Kč
    • •
  • 1 212 tis. Kč
    • •
  • AV ČR
Project

The relationship between the methylation status, structure and function of tobacco 5S rDNA locus (GA204/98/0191)

DNA structure, chromatin structuring and expression.Genomic sequencing of all methylcytosine residues in the 5S rDNA loci of the Nicotiana tabcum genome will be used to map the methylation status of the DNA and st...

CE - Biochemie

  • 1998 - 2000
    • •
  • 3 536 tis. Kč
    • •
  • 2 466 tis. Kč
    • •
  • GA ČR
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