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2 953 (0,151s)

Project

Applications of chemical structural probes and electroanalytical methods in DNA damage detection. Development of DNA sensors. (KJB4004302)

damage. Monitoring of DNA-damaging pollutants in the environment, together with analysis of damage to cellular DNA, belong to important steps in prevention of serious) in detection of DNA dam...

CG - Elektrochemie

  • 2003 - 2005
  • 2 052 tis. Kč
  • 1 212 tis. Kč
  • AV ČR
Project

Development of electrochemical biodetectors for DNA damage (IAA4004108)

electrochemical biodetector (biosensor) for DNA damage (both in vitro and in cells) and DNA damaging agents. A procedure developed in our laboratory which allows to detect DNA detection of DNA cl...

CG - Elektrochemie

  • 2001 - 2003
  • 1 758 tis. Kč
  • 804 tis. Kč
  • AV ČR
Project

Radiation damage to DNA protein complexes (1P05OC085)

assessment of partner bond and their damage in specific complex DNA-protein after irradiation by ionisating radiation...

BO - Biofyzika

  • 2005 - 2007
  • 2 320 tis. Kč
  • 981 tis. Kč
  • MŠMT
Project

Studies on DNA damage and apoptosis by genotoxic stress (ME 534)

Genotoxic treatment induces in plants DNA damage and various defence mechanisms to repair or eliminate damaged cells. By expression profiling of selected genes and detection of DNA integrity by Comet Assay we want ...

EB - Genetika a molekulární biologie

  • 2002 - 2004
  • 2 639 tis. Kč
  • 633 tis. Kč
  • MŠMT
Project

Translesion DNA synthesis across lesions induced by agents of biological significance. An insight into energetics, kinetics and mechanism (GA17-09436S)

The biological effects of DNA-damaging physical and chemical agents are associated with their ability to affect DNA replication. The main objective of DNA due to its damage by DNA-damaging

BO - Biofyzika

  • 2017 - 2019
  • 5 627 tis. Kč
  • 5 006 tis. Kč
  • GA ČR
Project

DNA damage tolerance by plants (ME 535)

Sequence analysis of Arabidopsis genome revealed several homologues of DNA polymerases identified in bacteria and mammals that tolerate several kinds of DNA damage during replication. This finding support previous observati...

EB - Genetika a molekulární biologie

  • 2002 - 2003
  • 1 405 tis. Kč
  • 355 tis. Kč
  • MŠMT
Project

New approaches in development of electrochemical sensors for DNA damage (GA203/04/1325)

The main roles of DNA in cells are to maintain and properly express genetic information. Damage to DNA in cells, upon interactions with a number of chemical electrochemical biosensors providing rapid and sensitive detection...

CG - Elektrochemie

  • 2004 - 2006
  • 2 707 tis. Kč
  • 2 707 tis. Kč
  • GA ČR
Project

Thermodynamics of DNA damaged by physical and chemical agents (GAP205/11/0856)

the hypothesis that ‘thermodymamic destabilization of DNA due to its damage by several of damaged DNA’. We will employ systems in the studies within this project in which it is possible to vary the character of th...

BO - Biofyzika

  • 2011 - 2015
  • 5 719 tis. Kč
  • 5 719 tis. Kč
  • GA ČR
Project

Targeting DNA interactions with platinum anticancer drugs with damaged-DNA binding-proteins (LH13096)

, in partucular on factors affecting interactions of DNA modified by these metallodrugs with damaged-DNA binding-proteins. The major motivation for formulation of this aim modified by polynuclear platinum compounds and mode...

CA - Anorganická chemie

  • 2013 - 2015
  • 1 866 tis. Kč
  • 1 866 tis. Kč
  • MŠMT
Project

Interactions of wild type and mutant p53 proteins with damaged DNA and their roles in cellular response to anticancer chemotherapy (IAA500040701)

and mut p53 interactions with damaged DNA, particularly DNA treated with antitumor specific DNA damage, (2) effects of DNA damage on the wt p53 sequence-specific DNAInteractions...

EB - Genetika a molekulární biologie

  • 2007 - 2010
  • 4 824 tis. Kč
  • 4 824 tis. Kč
  • AV ČR
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