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9 079 (0,182s) •

Project

Investigation of pathophysiology of human leukemias/lymphomas during manipulation of oncogenic microRNAs. (NS10310)

Translational research in hemato-oncology focused on identification of leukemia pathogenesis. Human chronic lymphocytic leukemia (CLL), difuse large B-cell lymphoma (DLBCL) and acute myeloid leukemia (AML)...

FD - Onkologie a hematologie

  • 2009 - 2011
    • •
  • 6 232 tis. Kč
    • •
  • 6 232 tis. Kč
    • •
  • MZ
Project

The analysis of molecular subtypes of diffuse large B-cell lymphoma by high-resolution arrayCGH for determination of genetic changes of prognostic importance (NT11103)

The study of genetic changes in cells of the tumor genome of patients with DLBCL using the array CGH, Q-RT-PCR and immunohistochemistry methods to acquire a comprehensive view of genetic changes. a) Based on preliminary results, to perform d...

FD - Onkologie a hematologie

  • 2010 - 2014
    • •
  • 6 499 tis. Kč
    • •
  • 6 479 tis. Kč
    • •
  • MZ
Project

Complex analysis of p53 tumor suppressor in non-Hodgkin´s lymphomas (NR9305)

The aim of this project is complex analysis of tumor suppressor p53 in tumor tissue of patients with diffuse large B-cell lymphoma and mantle cell lymphoma to verify whether p53 abberation is usef...

EB - Genetika a molekulární biologie

  • 2007 - 2009
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  • 2 494 tis. Kč
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  • 2 494 tis. Kč
    • •
  • MZ
Project

Therapy intensification of patients with Diffuse Large B Cell Lymphomas based on early FDG-PET positivity (prospective analysis) and retrospective evaluation of the changes in lymphoma therapy (NR9453)

-PET evaluation in young patients with diffuse larg B-cell lymphoma with lowThe aim of the project is the analysis of different lymphoma subgroups (follicular, marginal zone, peripheral T cells) a...

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 6 575 tis. Kč
    • •
  • 6 360 tis. Kč
    • •
  • MZ
Project

Diffuse large B-cell and follicular lymphoma - the analysis of prognostic factors and therapeutic strategies on patient´s outcome; Lymphoma Project in the Czech Republic. (NT12193)

large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) in the Czech Republic will be performed on Czech Lymphoma Study Group registry cohort of approx. 4000 patients. The ultimate goal of the...

FD - Onkologie a hematologie

  • 2011 - 2015
    • •
  • 6 992 tis. Kč
    • •
  • 6 864 tis. Kč
    • •
  • MZ
Project

Targeted inhibition of BCL2 family proteins in experimental therapy of diffuse large B-cell lymphoma (DLBCL) (NV15-27757A)

Diffuse large B-cell lymphoma (DLBCL) represents the most prevalent type of non-Hodgkin lymphomas (NHL) in the Western hemisphere. BCL2 and MCL1 belong to key clinically in diverse B-cell...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 6 991 tis. Kč
    • •
  • 6 991 tis. Kč
    • •
  • MZ
Project

Molecular Aspects of B-cell Receptor Signal Initiation as Targets for Specific Therapy of non-Hodgkin Lymphoma. (NV18-03-00117)

chemotherapy combination over 40 years old. The B-cell receptor (BCR) inhibition is such emerging therapy applicable to various B-cell derived NHL, which were shown to use) and “tonic” (analogous to baseline BCR s...

Oncology

  • 2018 - 2022
    • •
  • 11 156 tis. Kč
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  • 11 156 tis. Kč
    • •
  • MZ
Project

Modulation of cyclin-dependent kinases for targeted treatment of tumors with molecularly defined deregulation G1/S phase of cell cycle (GA20-25308S)

of the cell cycle (particularly the deregulation of CDK4, D-cyclins and CDKN2A in aggressive lymphomas. Inhibition of CDK4/6 makes sense in lymphomas where the type D, CDK4 amplification, or where CDKN2A deletions (mantle ...

Medicinal chemistry

  • 2020 - 2022
    • •
  • 9 640 tis. Kč
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  • 9 640 tis. Kč
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  • GA ČR
Project

The study of mech.of proto-oncog.activ.and tumor supressor genes inactiv.by fluresc.in situ hybridiz.(FISH)and compar. genomic hybridiz.(CGH)in pat.with non-Hodgkinś lymph.(NHL). (NC6209)

of chromosomal changes in mantle cell lymphoma (MCL),folicular lymphoma (FL) and diffuse large B-cell lymphoma (B-DLCL). Mapping of most frequent regions involved in changes......

FD - Onkologie a hematologie

  • 2000 - 2002
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  • 2 582 tis. Kč
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  • 2 571 tis. Kč
    • •
  • MZ
Project

Identification of novel risk factors and molecular mechanisms of central nervous system relapse in diffuse large B-cell lymphoma (NU23-03-00127)

Central nervous system (CNS) relapse in diffuse large B-cell lymphoma (DLBCL molecular mechanisms that enable lymphoma cell evasion and survival in CNS. We will compare genetic and single cell...

Hematology

  • 2023 - 2026
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  • 14 404 tis. Kč
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  • 14 404 tis. Kč
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  • MZ
  • 1 - 10 out of 9 079