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134 (0,114s) •

Project

Increasing of Safety and Reliability of High-Voltage System at Self-consumption of Electrical Industry and Manufacturing Plants. (2A-2TP1/102)

Increasing of safety and reliability of high-voltage system at self-consumption electrical industry or manufacturing plant is principal purpose of project with using decision analysis. The decision analysis is developed with support of mathematical m...

JE - Nejaderná energetika, spotřeba a užití energie

  • 2007 - 2010
    • •
  • 4 700 tis. Kč
    • •
  • 2 938 tis. Kč
    • •
  • MPO
Project

A paradigm shift for Trypanosoma brucei ATP production rewiring of mitochondrial metabolism allows for the infection of various host environments (GA20-14409S)

of the human pathogen, Trypanosoma brucei, states that the mitochondrion is an ATP consuming organelle and glycolysis is the only source of cellular ATP. Therefore, the ATP/ADP carrier (AAC) transports cytosolic ATP

Cell biology

  • 2020 - 2023
    • •
  • 9 719 tis. Kč
    • •
  • 9 719 tis. Kč
    • •
  • GA ČR
Project

Structure and dynamics of high and low affinity ATP binding sites of Na+/K+-ATPase (GA204/98/0468)

Na+/K+-ATPase has two ATP sites which cooperate during catalysis in a negative coopartive way with ATP as substrate and in a positive cooperative way with MANT-ATP. The high affinity ATP site (E1ATP site) can be mo...

EE - Mikrobiologie, virologie

  • 1998 - 2000
    • •
  • 1 111 tis. Kč
    • •
  • 916 tis. Kč
    • •
  • GA ČR
Project

Molecular Fluorescent Probes for Selective Detection of Adenosine‐5’‐Triphosphate (ATP) (8J19UA048)

Elaboration of molecular fluorescent probes and test systems on their basis for selective detection of adenosine-5’-triphosphate (ATP) in aqueous solutions, and their following applications in pharmacology (as a method of preclinical investi...

Organic chemistry

  • 2019 - 2020
    • •
  • 92 tis. Kč
    • •
  • 92 tis. Kč
    • •
  • MŠMT
Project

Trangenic and pharmacological complementation of inherited ATP synthase disorders (NV16-33018A)

Inborn deficiency of ATP synthase, the key enzyme of cellular energy provision as it is not absolutely essential for ATP synthase biogenesis and sufficient recovery of ATP production can be expected even after partial incre...

FG - Pediatrie

  • 2016 - 2019
    • •
  • 14 567 tis. Kč
    • •
  • 14 567 tis. Kč
    • •
  • MZ
Project

DAPIT protein and its role in biogenesis of mitochondrial ATP synthase (GA16-01813S)

FoF1-ATP synthase composed of 15 core structural subunits is the key enzyme of mitochondrial energy provision, responsible for production of most cellular ATP. Recently of this novel protein for biogenesis of ATP synthase, ...

EB - Genetika a molekulární biologie

  • 2016 - 2020
    • •
  • 6 121 tis. Kč
    • •
  • 5 839 tis. Kč
    • •
  • GA ČR
Project

Mechanism of ATP synthase biogenesis and the role of TMEM70 protein (GAP303/11/0970)

ATP synthase is the key enzyme of mitochondrial energy provision, responsible for production of most cellular ATP. Enzyme biogenesis results from expression of both that are assembled into a functional ATP synthase in a ste...

CE - Biochemie

  • 2011 - 2015
    • •
  • 8 963 tis. Kč
    • •
  • 8 963 tis. Kč
    • •
  • GA ČR
Project

Functional analysis of two novel subunits of the F0F1-ATP synthase complex in Trypanosoma brucei (GP204/09/P563)

F0F1-ATP synthase plays an essential role in Trypanosoma brucei, an important and a mammalian host. Interestingly, the function of the mitochondrial (mt) F0F1-ATP synthase differsbetween the insect and mammalian stages, producing

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 1 077 tis. Kč
    • •
  • 1 077 tis. Kč
    • •
  • GA ČR
Project

The role of ATP synthase structure in the biogenesis and bioenergetics of the unique Trypanosoma brucei mitochondrion (GA18-17529S)

- the presence of ATP synthase dimer rows at the crista ridges. Little is known about and ATP-producing mitochondrion transitions to a streamlined tubular, cristae-lacking and ATP-consuming organelle. Combining traditional...

Biochemistry and molecular biology

  • 2018 - 2022
    • •
  • 6 731 tis. Kč
    • •
  • 6 512 tis. Kč
    • •
  • GA ČR
Project

Structure and function of receptors activated by extracellular ATP (IAA500110910)

Extracellular ATP activated purinergic P2X receptors represent a novel structural type of ligand-gated ion channels. ATP binding site and the mechanism of channel opening are still not well understood. In the proposed project we wou...

FH - Neurologie, neurochirurgie, neurovědy

  • 2009 - 2013
    • •
  • 3 970 tis. Kč
    • •
  • 3 970 tis. Kč
    • •
  • AV ČR
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