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51 (0,086s) •

Project

From conformation to biological functions of HP1 protein (GA18-07384S)

by means of FLIM-FRET microscopy as well as biological functions of HP1 proteins with different FLIM characteristics. Three variants of HP1 protein (HP1α, HP1β, HP1γ) as well......

Cell biology

  • 2018 - 2020
    • •
  • 10 461 tis. Kč
    • •
  • 8 850 tis. Kč
    • •
  • GA ČR
Project

Role of nucleophosmin interactome in acute myeloid leukemia with mutated NPM (GA19-04099S)

methods (e.g. FLIM, FRET, GFP-Trap) we will evaluate unknown/neglected relations...

Cell biology

  • 2019 - 2022
    • •
  • 8 332 tis. Kč
    • •
  • 7 618 tis. Kč
    • •
  • GA ČR
Project

Flurescence microscopy in biological and medical research (LC06063)

The main objective is development of new methods in fluorescence microscopy for investigation of structure and dynamics of living cells and model systems. The methodological part contains experimental techniques (FLIM, FCS, super-resolution ...

EB - Genetika a molekulární biologie

  • 2006 - 2011
    • •
  • 94 587 tis. Kč
    • •
  • 93 988 tis. Kč
    • •
  • MŠMT
Project

Structural and biophysical basis of the reaction mechanism of intramembrane proteolysis (GA18-09556S)

crystallography, NMR spectroscopy with molecular modelling, and fluorescence techniques (FRET-FLIM, FCS) to investigate substrate-enzyme interactions, dimerisation......

Biochemistry and molecular biology

  • 2018 - 2022
    • •
  • 8 212 tis. Kč
    • •
  • 6 973 tis. Kč
    • •
  • GA ČR
Project

Fluorescence lifetime micro-endoscopy for in-vivo deep brain studies (GA25-18280S)

, we will introduce the prospect of Fluorescence Lifetime Imaging Microscopy (FLIM) through hair-thin multimode fibres. The minimally invasive FLIM endoscope will offer-brain structures. As an alternative to the traditional (time-do...

Optics (including laser optics and quantum optics)

  • 2025 - 2027
    • •
  • 8 885 tis. Kč
    • •
  • 7 972 tis. Kč
    • •
  • GA ČR
Project

Phenomenological criteria of fatigue life under fretting conditions (GA101/09/1709)

Reduced fatigue life is typical for damage process known as fretting (contact) Comparison of chosen published or newly designed phenomenological fretting fatigue of fretting fatigue life prediction according to these criter...

JL - Únava materiálu a lomová mechanika

  • 2009 - 2011
    • •
  • 2 282 tis. Kč
    • •
  • 2 282 tis. Kč
    • •
  • GA ČR
Project

Role of acute myeloid leukemia-associated nucleophosmin mutations in the NPM-p53-Mdm2 regulatory network (GA22-03875S)

Nucleophosmin (NPM) mutations characteristic for the acute myeloid leukemia (AML) cause aberrant cytoplasmic localization of NPM and many of its interaction partners, e.g. of tumor suppressor p53. The p53 level is regulated at several stages by mdm2,...

Cell biology

  • 2022 - 2024
    • •
  • 8 442 tis. Kč
    • •
  • 8 238 tis. Kč
    • •
  • GA ČR
Project

The role of gangliosides in the development of neurodegenerative amyloidogenic diseases Molecular insights by advanced fluorescence microscopy (GA17-03160S)

Ab peptide oligomers are neurotoxic and thought to be implicated in Alzheimer’s disease (AD). Formation of Ab oligomers in the brain may be mediated by neuronal membranes. Although the metabolism of the lipid class “ganglioside” is linked to AD their...

BO - Biofyzika

  • 2017 - 2019
    • •
  • 6 342 tis. Kč
    • •
  • 5 661 tis. Kč
    • •
  • GA ČR
Project

Multi-FRET fluorescent probes responding to hydrolases (GA19-23972S)

The project is focused on synthesis of model systems for detection of two or three proteases solely or in their mixture via fluorescence multi-FRET effect. The systems will be based on three/four dyes connected with linkers cleavable by the ...

Organic chemistry

  • 2019 - 2021
    • •
  • 5 070 tis. Kč
    • •
  • 5 070 tis. Kč
    • •
  • GA ČR
Project

Analysis of Src kinase activation using a novel FRET-based biosensor (GA15-07321S)

the conformational changes following Src activation to construct a genetically encoded FRET based...

EB - Genetika a molekulární biologie

  • 2015 - 2019
    • •
  • 4 170 tis. Kč
    • •
  • 4 170 tis. Kč
    • •
  • GA ČR
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