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4 (0,071s)

Project

Molecular basis of interaction between FOXO Forkhead transcription factors and tumor suppressor p53 (GA21-02080S)

of the interaction between Forkhead box O (FOXO) transcription factors and tumor suppressor p53 and FOXO transcription factors physically interact and that this interaction plays the interaction between p53 and FOXO are st...

Biochemistry and molecular biology

  • 2021 - 2024
  • 8 540 tis. Kč
  • 8 507 tis. Kč
  • GA ČR
Project

Study of the interactions between forkhead transcription factor AFX and DNA. (LZ1K03020)

AFX belongs to FOXO subfamily of Forkhead transcription factors, which are involved in metabolism control, embryogenesis, apoptosis, and tumorigenesis. Activity and association with 14-3-3 proteins. FOXO transcription factors specif...

CE - Biochemie

  • 2003 - 2005
  • 1 321 tis. Kč
  • 1 152 tis. Kč
  • MŠMT
Project

Inhibition of FOXO3-DNA interaction by small molecule inhibitors (GF17-33854L)

FOXO transcription factors control apoptosis, stress resistance and longevity in mammalian cells. Although the members of the FOXO family act as tumor suppressors in some cell types, emerging evidence suggests that FOXO3 also contri...

CE - Biochemie

  • 2017 - 2019
  • 7 063 tis. Kč
  • 6 675 tis. Kč
  • GA ČR
Project

Molecular mechanism of apoptosis induced by alfa-tocopheryl succinate in cancer cells. (KJB500970904)

of Noxa gene expression (we have strong evidences that FoxO transcription factors...

EB - Genetika a molekulární biologie

  • 2009 - 2010
  • 971 tis. Kč
  • 971 tis. Kč
  • AV ČR
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