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3 940 (0,134s) •

Project

Subcellular distribution of mu- and delta-opioid receptors and functional activity of trimeric G proteins after the long-term morphine stimulation. (GA309/06/0121)

hypothesis isbased on up-regulation of the newly synthesised receptors and G proteins, the basis of opioid tolerance or addiction observed after long-term stimulation......

ED - Fyziologie

  • 2006 - 2008
    • •
  • 3 975 tis. Kč
    • •
  • 3 975 tis. Kč
    • •
  • GA ČR
Project

The role subcellular redistribution of trimeric G proteins in mechanism of hormone action and desensitisation (GA309/01/0255)

Sustained hormone stimulation of target cells results in desensitization of hormone (neurotransmitter) response, which is associated with internalisation, solubilization and down-regulation (decrease in total cellular amount) of trimeric GTP...

FH - Neurologie, neurochirurgie, neurovědy

  • 2001 - 2003
    • •
  • 4 742 tis. Kč
    • •
  • 2 709 tis. Kč
    • •
  • GA ČR
Project

Insights into mechanisms of G protein signaling by the β2-adrenergic receptor (GJ17-14413Y)

The beta2-adrenergic receptor (b2AR) is the archetypal G protein coupled of these G proteins dissociate into free Ga and Gbg subunits or rearrange upon activation to stimulatory Gs and inhibitory Gi proteins

ED - Fyziologie

  • 2017 - 2021
    • •
  • 2 581 tis. Kč
    • •
  • 2 581 tis. Kč
    • •
  • GA ČR
Project

Role of receptor/G protein preassembly in G protein signaling (GJ20-09628Y)

G proteins and G protein-coupled receptors (GPCRs) play a key role in cellular signal transduction. An important aspect of G protein signaling, the role of which and G protein mo...

Biophysics

  • 2020 - 2022
    • •
  • 4 908 tis. Kč
    • •
  • 4 875 tis. Kč
    • •
  • GA ČR
Project

Enhancement of G-CSF action by adenosine signalling testing of its potential clinical use in murine models (GA306/99/0027)

effects of granulocyte colony-stimulating factor (G-CSF) and drugs elevating with respect to the clinical use of G-CSF. Interactions of G-CSF with dipyridamole and AMP will be studied in the following two experime...

ED - Fyziologie

  • 1999 - 2001
    • •
  • 2 397 tis. Kč
    • •
  • 1 821 tis. Kč
    • •
  • GA ČR
Project

Caveolin-mediated internalisation of trimeric G proteins Gq/G11 - one of the mechanisms long-term desensitisation? (GP305/06/P071)

-(thyrotropin-releasing hormone, TRH) induced endocytosis of trimeric Gq/G11 proteins will be also tested.The internalisation of Gq/G11 alpha proteins will be followed domains/caveolae by construction of fusion proteins bet...

ED - Fyziologie

  • 2006 - 2008
    • •
  • 758 tis. Kč
    • •
  • 758 tis. Kč
    • •
  • GA ČR
Project

Calcium signaling in neonatal rat gonadotrophs (IAA5011105)

receptor coupled to G protein which stimulates oscillatory calcium release from the roleof ryanodine receptor and protein kinase C, the mechanism of melatonin action......

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 2 917 tis. Kč
    • •
  • 848 tis. Kč
    • •
  • AV ČR
Project

Heterotrimeric G-protein signaling and its role in regulation of cell proliferation and morphogenesis in plants (LD15149)

activity of G-protein complex on sugar metabolism (realization till 12/2015) 2) To describe expression of genes encoding components of G-protein signaling complex during (realization till 12/2016) 3) To analyze th...

ED - Fyziologie

  • 2015 - 2017
    • •
  • 1 039 tis. Kč
    • •
  • 1 039 tis. Kč
    • •
  • MŠMT
Project

Visualizing GPCR-G-protein-beta-arrestin supercomplexes in living cells using two-photon polarization microscopy (LTAIN19167)

To observe the presence and intracellular localization of GPCR-G-protein-beta-arrestin supercomplexes in order to determine their physiological role.......

Biophysics

  • 2020 - 2022
    • •
  • 4 754 tis. Kč
    • •
  • 4 754 tis. Kč
    • •
  • MŠMT
Project

Influence of allosteric modulators on specificity of coupling with G-proteins and desensitization of muscarinic receptors (GA305/05/0452)

In spite of preferential coupling of muscarinic receptors to distinct classes of heterotrimeric G proteins, they can also interact with other G proteins. Allosteric alter receptor preference for G prot...

ED - Fyziologie

  • 2005 - 2007
    • •
  • 4 992 tis. Kč
    • •
  • 4 992 tis. Kč
    • •
  • GA ČR
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