All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”
EN
ČeštinaEnglish

Filters

473 (0,118s) •

Project

Templated synthesis and product characterization focused at development of potent and selective ligands of c-myc G-quadruplex (GA17-04393S)

Rational design of novel ligands of c-myc G-quadruplex is inherently difficult this shortcoming and identify novel binders of c-myc G-quadruplex we propose to explore in situ. Specifically, c-myc G-qua...

CC - Organická chemie

  • 2017 - 2018
    • •
  • 4 135 tis. Kč
    • •
  • 2 994 tis. Kč
    • •
  • GA ČR
Project

Guanine quadruplex-mediated functions of p53, p63 and p73 proteins in cancer biology (GA19-15168S)

G-quadruplexes, non-B DNA structures, are linked to regulation of transcription, replication and genome stability. In the previous project, we showed that G-quadruplexes project is designed to prove G-...

Biochemistry and molecular biology

  • 2019 - 2022
    • •
  • 3 782 tis. Kč
    • •
  • 3 776 tis. Kč
    • •
  • GA ČR
Project

Role of cytosine in the conformational polymorphism of DNA (IAA4004701)

) forms at neutral pH, and its role in the formation of cytosine i-quadruplex. The anomalousconformation of d(CnGn) oligonucleotides.Duplex,G-quadruplex and i-quadruplex formation coexistence. Bimolecular duplex-fo...

BO - Biofyzika

  • 1997 - 1999
    • •
  • 3 750 tis. Kč
    • •
  • 1 425 tis. Kč
    • •
  • AV ČR
Project

Interactions of p53 family proteins with biologically significant DNA quadruplexes (GA13-36108S)

and map of tumor suppressor p53 family member’s interactions with G-quadruplexes of p53 interaction with DNA. Human genome is enriched in DNA sequences with G-quadruplex-forming potential (repetitive sequences, on...

EB - Genetika a molekulární biologie

  • 2013 - 2015
    • •
  • 4 919 tis. Kč
    • •
  • 4 919 tis. Kč
    • •
  • GA ČR
Project

Polymorphic G-quadruplexes in gene promoters (GA17-12075S)

G-quadruplexes (G4) are tetraplex DNA structures. G4 forming sequences are abundant in human genome. G4s are notably overrepresented in promoter regions of genes. G4 forming sequences from the promoter regions contributing to transc...

CE - Biochemie

  • 2017 - 2019
    • •
  • 10 826 tis. Kč
    • •
  • 9 812 tis. Kč
    • •
  • GA ČR
Project

Dynamic polymorphism of non-canonical nucleic acids structures in the intracellular space (GF24-10605K)

Dynamic transitions between B-DNA and tetraplex DNA structures, particularly G-quadruplexes and i-motifs, contributes to the regulatory control of genome integrity and gene expression. Formation of RNA G-quadruplexes

Biochemical research methods

  • 2024 - 2027
    • •
  • 10 419 tis. Kč
    • •
  • 10 203 tis. Kč
    • •
  • GA ČR
Project

Identification and characterization of proteins involved in G-quadruplex and R-loop metabolism and their relationship with DNA replication (GX21-22593X)

DNA replication is an essential and one of the most complex processes in the cell. Not only exogenous DNA damage but also intrinsic DNA structures including G-quadruplexes (G4) and R-loops, their stabilization or unscheduled formati...

Biochemistry and molecular biology

  • 2021 - 2025
    • •
  • 49 901 tis. Kč
    • •
  • 49 901 tis. Kč
    • •
  • GA ČR
Project

Regulation of the embryonic stem cell pluripotency factor Oct4 via guanine quadruplex in its promoter (GP14-33947P)

are unusually guanine rich and, thus, may potentially form guanine quadruplexes. These sites is the quadruplex involved in the regulation of the Oct4 and, in fact, in an origin and differentiation of ES cells. We will elucidate the...

BO - Biofyzika

  • 2014 - 2016
    • •
  • 1 505 tis. Kč
    • •
  • 1 505 tis. Kč
    • •
  • GA ČR
Project

Structural gymnastics of nucleic acids from molecular principles through biological functions to therapeutic targets. (EF15_003/0000477)

The aim of the project is to build a top-class interdisciplinary team capable (based on broad methodological and thematic scope) to effectively solve complex problems in the research of alternative structures of nucleic acids.......

EB - Genetika a molekulární biologie

  • 2016 - 2022
    • •
  • 158 315 tis. Kč
    • •
  • 153 331 tis. Kč
    • •
  • MŠMT
Project

Structure, biology and medical potential of blood plasma-derived ultra-short cell-free DNA (GF22-04242L)

that these sites are only enriched in US cfDNA when they contain the potential to adopt G-quadruplex and/or i-motif structures. Importantly, our data revealed that the US cfDNA......

Oncology

  • 2022 - 2025
    • •
  • 10 272 tis. Kč
    • •
  • 9 732 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 473