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1 095 (0,119s) •

Project

Molecular mechanism of GABA B receptor regulation by KCTD proteins (GA14-28334S)

GABA B receptor is the metabotropic receptor for the main inhibitory neurotransmitter GABA (γ-aminobutyric acid). It plays essential role in many physiological identified as auxiliary subunits of the GABA ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2014 - 2018
    • •
  • 4 425 tis. Kč
    • •
  • 4 425 tis. Kč
    • •
  • GA ČR
Project

Molecular studies on the structure of the heteromeric GABA-B receptors (NF6704)

The aim of our studies is to map portions of the BR1 and BR2 proteins that are in close proximity and contribute to the protein-protein interactions that are involvolved in the structural formation of the functional GABA-B receptors...

FE - Ostatní obory vnitřního lékařství

  • 2001 - 2003
    • •
  • 1 849 tis. Kč
    • •
  • 1 723 tis. Kč
    • •
  • MZ
Project

Drugs influencing GABA-B receptors in pediatric medicine (GAP304/10/1274)

Present project will be focused on the role of GABA-B receptors in seizures and hippocampal epileptic afterdischarges, In the same model the role of GABA-B receptors administration of benzodiazepines. In addition, ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2010 - 2012
    • •
  • 4 034 tis. Kč
    • •
  • 4 034 tis. Kč
    • •
  • GA ČR
Project

The role of neuroactive steroids in the disorders of nervous system (NB6691)

The method of determination of pregnanolones and their conjugates will be developed. The levels of steroid modulators of GABA and NMDA receptors will be evaluated in controls, epileptic women during menstrual cycle and in patients w...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2001 - 2003
    • •
  • 3 946 tis. Kč
    • •
  • 3 320 tis. Kč
    • •
  • MZ
Project

Experimental therapy and receptor mechanism of benzodiazepine dependence studied by PCR in situ. (IZ3612)

FL - Psychiatrie, sexuologie

  • 1996 - 1998
    • •
  • 1 457 tis. Kč
    • •
  • 1 457 tis. Kč
    • •
  • MZ
Project

The role of GABA-B receptors in the mammalian MNTB (GA309/06/1304)

GABAB receptors (GABABRs) modulate synaptic transmission by controlling neurotransmitter release and by inducing postsynaptic hyperpolarization. At many central synapses GABABRs localize to either side of the junction. The individual contrib...

FH - Neurologie, neurochirurgie, neurovědy

  • 2006 - 2008
    • •
  • 2 610 tis. Kč
    • •
  • 2 610 tis. Kč
    • •
  • GA ČR
Project

Developmental plasticity of GABA- and glycinergic systems in the rat medial nucleus of the trapezoid body (GA309/03/1158)

with immunohistochemical detection of GABA, glycine and their receptors. Our research is also aimed whileinhibitory fibers are supposed to be GABA- and glycinergic. Calyx of Held contains functional GABAA and glycine r...

ED - Fyziologie

  • 2003 - 2005
    • •
  • 2 329 tis. Kč
    • •
  • 2 329 tis. Kč
    • •
  • GA ČR
Project

Neuroactive steroids, imunomodulatory steroids and ergosteroids in pregnancy and around parturition. (NB7070)

Verification of the role of GABA-receptor activators in maintenance of pregnancy, elicitation of parturition and postpartum complications will contribude to their potential therapeutical application. We intend to investigate the pro...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2002 - 2004
    • •
  • 2 928 tis. Kč
    • •
  • 2 894 tis. Kč
    • •
  • MZ
Project

GA BA-benzodiazepine mechanisms of benzodiazepine withdrawal (GA309/96/0463)

at benzodiazepine receptors of the GABA a- benzodiazepine receptor. It is now a well-established syndrome. Therefore, we propose to study the role of the benzodiazepine-GABA receptor withdrawal provides l...

FR - Farmakologie a lékárnická chemie

  • 1996 - 1998
    • •
  • 1 382 tis. Kč
    • •
  • 915 tis. Kč
    • •
  • GA ČR
Project

Developmental pharmakology of GABA-B systém its role in epilepsy,cognition and pain (GA305/05/2581)

GABA-B receptors belong to the family of G-protein coupled receptors. They are extensively studied only during the last ten years and the number of data of GABA-B system in epilepsies, cognition and analgesia in de...

FR - Farmakologie a lékárnická chemie

  • 2005 - 2007
    • •
  • 3 821 tis. Kč
    • •
  • 3 821 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 1 095