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1 726 (0,082s) •

Project

Drugs influencing GABA-B receptors in pediatric medicine (GAP304/10/1274)

Present project will be focused on the role of GABA-B receptors in seizures and hippocampal epileptic afterdischarges, In the same model the role of GABA-B receptors administration of benzodiazepines. In addition, ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2010 - 2012
    • •
  • 4 034 tis. Kč
    • •
  • 4 034 tis. Kč
    • •
  • GA ČR
Project

Molecular studies on the structure of the heteromeric GABA-B receptors (NF6704)

The aim of our studies is to map portions of the BR1 and BR2 proteins that are in close proximity and contribute to the protein-protein interactions that are involvolved in the structural formation of the functional GABA-B receptors...

FE - Ostatní obory vnitřního lékařství

  • 2001 - 2003
    • •
  • 1 849 tis. Kč
    • •
  • 1 723 tis. Kč
    • •
  • MZ
Project

Molecular mechanism of GABA B receptor regulation by KCTD proteins (GA14-28334S)

GABA B receptor is the metabotropic receptor for the main inhibitory neurotransmitter GABA (γ-aminobutyric acid). It plays essential role in many physiological identified as auxiliary subunits of the GABA B

FH - Neurologie, neurochirurgie, neurovědy

  • 2014 - 2018
    • •
  • 4 425 tis. Kč
    • •
  • 4 425 tis. Kč
    • •
  • GA ČR
Project

Developmental pharmakology of GABA-B systém its role in epilepsy,cognition and pain (GA305/05/2581)

GABA-B receptors belong to the family of G-protein coupled receptors. They are extensively studied only during the last ten years and the number of data of GABA-B system in epilepsies, cognition and analgesia in de...

FR - Farmakologie a lékárnická chemie

  • 2005 - 2007
    • •
  • 3 821 tis. Kč
    • •
  • 3 821 tis. Kč
    • •
  • GA ČR
Project

The role of GABA-B receptors in the mammalian MNTB (GA309/06/1304)

of GABA using live brainstem slices isolated from wild type and GABABR knock-out mice...

FH - Neurologie, neurochirurgie, neurovědy

  • 2006 - 2008
    • •
  • 2 610 tis. Kč
    • •
  • 2 610 tis. Kč
    • •
  • GA ČR
Project

Two subunits in GABA-B receptor formation dimmers or more? (GA301/00/0654)

in performance of some heptahelical receptors. The gama-amino-butyric acid (GABA)GABAb...

FP - Ostatní lékařské obory

  • 2000 - 2002
    • •
  • 4 099 tis. Kč
    • •
  • 4 099 tis. Kč
    • •
  • GA ČR
Project

Experimental therapy of opiate dependence with psychotropic drugs behavioural and neurobiological aspects. (NF5513)

Repeated morphine administrations: changes/disorders of social behaviour in animal models, therapeutic effects of benzodiazepines, GABA changes studied with RT-PCR an mcrodialysis......

FH - Neurologie, neurochirurgie, neurovědy

  • 1999 - 2001
    • •
  • 2 294 tis. Kč
    • •
  • 2 294 tis. Kč
    • •
  • MZ
Project

Is the main inhibitory system damaged in progressive epileptogenesis after pilocarpine-induced seizures in adult and immature rats? (GA309/97/0552)

. The role of this system and especially the synthesis of GABA will be studied in a model- in rats 12, 25 and 90 days old. An enzyme synthesizing GABA, glutamate decarboxylase will be measured biochemically. In addition, brain level...

FH - Neurologie, neurochirurgie, neurovědy

  • 1997 - 1999
    • •
  • 4 981 tis. Kč
    • •
  • 2 946 tis. Kč
    • •
  • GA ČR
Project

Diagnostic markers and pathophysiological mechanisms of atypical parkinsonian syndromes (NT12288)

The project is designed to study clinical and paraclinical markers with a high positive predictive diagnostic value for atypical parkinsonian syndromes and to investigate the contribution of the inhibitory GABA-ergic system in the disorders ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2011 - 2015
    • •
  • 8 122 tis. Kč
    • •
  • 8 122 tis. Kč
    • •
  • MZ
Project

GA BA-benzodiazepine mechanisms of benzodiazepine withdrawal (GA309/96/0463)

at benzodiazepine receptors of the GABA a- benzodiazepine receptor. It is now a well-established withdrawal provides little data on the role of the GABA/benzodiazepine mechanisms syndrome. Therefore, we propose to study the role of...

FR - Farmakologie a lékárnická chemie

  • 1996 - 1998
    • •
  • 1 382 tis. Kč
    • •
  • 915 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 1 726