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27 (0,098s) •

Project

Role of GIT-PIX signaling complex in regulation of microtubule nucleation in mast cells (GA15-22194S)

complexes with GIT and PIX signaling proteins that are phosphorylated during mast cell activation. It is known that GIT-PIX signal complex plays an important role in regulation of kinase PAK that modulates centrosome maturation. Th...

EA - Morfologické obory a cytologie

  • 2015 - 2017
    • •
  • 5 725 tis. Kč
    • •
  • 5 725 tis. Kč
    • •
  • GA ČR
Project

Role of protein tyrosine kinases and phosphatases in the regulation of microtubule nucleation during mast cell activation (GA21-30281S)

stimulates MT formation and that GIT adaptor protein interacts with γ-tubulin kinases of Src family phosphorylate GIT. We recently showed that tyrosine phosphatase SHP-1 modulates GIT phosphorylation and MT nucleation. Thi...

Cell biology

  • 2021 - 2023
    • •
  • 7 800 tis. Kč
    • •
  • 7 800 tis. Kč
    • •
  • GA ČR
Project

Neonates with congenital anomalies of gastrointestinal tract new approaches to prevention and diagnosis of necrotizing enterocolitis and sepsis (NT13483)

period after correction of congenital anomalies GIT(CA GIT). The cause of NEC threatening GIT problems remains impossible. We also do not have reliable data about gut mucosal compromise in children with CA GIT. We...

FJ - Chirurgie včetně transplantologie

  • 2012 - 2015
    • •
  • 8 044 tis. Kč
    • •
  • 8 044 tis. Kč
    • •
  • MZ
Project

Modelling of condicional risks of incidence GIT tumours in patients with metabolic syndrome Z (NB6635)

The aim of this proposed study is to prove the prevalence rate of some types of GIT cancer in patients with various metabolic syndrome and to find biological reasons of it based on laboratory measurements. dynamic changes of the biological b...

FE - Ostatní obory vnitřního lékařství

  • 2001 - 2003
    • •
  • 2 653 tis. Kč
    • •
  • 2 645 tis. Kč
    • •
  • MZ
Project

Microtubule nucleation in activated mast cells regulatory role of phosphorylated GIT proteins (GA18-27197S)

-dependent MT nucleation, and that phosphorylated GIT protein form complexes with g-dependent PKC families can phosphorylate GIT. The aim of this project is to evaluate our, specify their cellular localization, identify phosphorylat...

Cell biology

  • 2018 - 2020
    • •
  • 6 998 tis. Kč
    • •
  • 6 140 tis. Kč
    • •
  • GA ČR
Project

Looking for biomarkers of upper gastrointestinal tract tumors by the use of proteomic profiling. (NT14282)

Cancers of the upper GIT are common but very difficult to treat cancers. The prognosis of patients with tumors of the upper GIT is uncertain and treatment options are limited. Currently, there is intensive search for biomarkers that...

FJ - Chirurgie včetně transplantologie

  • 2013 - 2015
    • •
  • 6 056 tis. Kč
    • •
  • 6 056 tis. Kč
    • •
  • MZ
Project

Research and development of innovative compounds with complex effects and methods of their binding to new generation transporters for targeted transport of active substances in the GIT of poultry (FW06010066)

with targeted transport in the poultry GIT for the above substances. The addressed problem...

Animal and dairy science; (Animal biotechnology to be 4.4)

  • 2023 - 2026
    • •
  • 32 905 tis. Kč
    • •
  • 23 018 tis. Kč
    • •
  • TA ČR
Project

Analysis of microtubular changes during activation of mast cells (GPP302/11/P709)

activation. Very recently we have identified these proteins as GIT and PIX. They form of GIT and PIX in mast cell activation is unknown. The aim of this research project is to elucidate the role of GIT and PIX in the regul...

EA - Morfologické obory a cytologie

  • 2011 - 2013
    • •
  • 2 100 tis. Kč
    • •
  • 2 100 tis. Kč
    • •
  • GA ČR
Project

Role of GIT proteins in regulation of microtubule organization in glioblastoma cells (LTAUSA19118)

tumors. Specific aims: 1. Correlation between expression of GIT proteins-tubulin and signaling proteins. Determination of the effect of GIT proteins of GIT protein depletion/deletion on microtubule nucleation, cell migrati...

Biochemistry and molecular biology

  • 2020 - 2022
    • •
  • 3 900 tis. Kč
    • •
  • 3 900 tis. Kč
    • •
  • MŠMT
Project

Isolation and characterization of bilirubin reductase gene from bacteria of Clostridium genus and its potential therapeutic use (GA310/02/1436)

(GIT) a substantial part of intestinal bilirubin may be reabsorbed. In the prior studieswe have described the role of early colonisation of the neonatal GIT encapsulated enzyme or colonization of animal GIT with nonpathoge...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2002 - 2004
    • •
  • 4 926 tis. Kč
    • •
  • 3 678 tis. Kč
    • •
  • GA ČR
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