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2 620 (0,158s) •

Project

Genetic predispositions to myeloproliferative neoplasms in JAK/STAT pathway (LTAUSA17142)

The aims of this project is the identification of the new genetic predisposition to myeloproliferative neoplasms (MPN) and their in vitro/vivo characterization coexist with predisposing genetic variations in MPN. Reliable c...

EB - Genetika a molekulární biologie

  • 2017 - 2021
    • •
  • 3 996 tis. Kč
    • •
  • 3 996 tis. Kč
    • •
  • MŠMT
Project

Hereditary cancer predisposition in breast or colorectal cancer patients not indicated for routine genetic testing (NU20-03-00283)

in tens of clinically relevant cancer predisposition genes influences treatment to individuals fulfilling genetic testing criteria. In pilot analysis, we revealed presence not indicated for routine genetic testing. We aim ...

Oncology

  • 2020 - 2023
    • •
  • 11 720 tis. Kč
    • •
  • 11 720 tis. Kč
    • •
  • MZ
Project

Personalized genetic analyzes based on the principle of next-generation sequencing technology (EI22_002/0000363)

of selected genetic predispositions and for the study of the intestinal microbiome of molecular diagnostics with a focus on the development of personalized genetic tests will be new prototypes and functional samples for th...

Genetics and heredity (medical genetics to be 3)

  • 2023 - 2025
    • •
  • 26 165 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • MPO
Project

Genetic Aspects of Polyglandular Autoimmune Endocrinopathies. (NB6317)

We will concentrate on the study of the genetic predisposition (HLA, Fas/FasL by laboratory, and clinical parameters can also be differentiated by their genetic predispositions. It has to be elucidated whether or n...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2000 - 2002
    • •
  • 2 813 tis. Kč
    • •
  • 2 461 tis. Kč
    • •
  • MZ
Project

DiPha (EI22_002/0000717)

for obtaining comprehensive information about genetic predisposition individualsOne of the key roles of an individual's reaction to drugs is played by genetic of pharmacogenetic predispositions in the general popu...

Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

  • 2023 - 2026
    • •
  • 47 106 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • MPO
Project

Genetic disection of multigenetic predisposition to disease in the mouse model (OK 394)

Tumour of strangulate and procedure to the Leishnania major...

FD - Onkologie a hematologie

  • 1999 - 2001
    • •
  • 5 085 tis. Kč
    • •
  • 1 515 tis. Kč
    • •
  • MŠMT
Project

Molecular characterization of autoimmune polyglandular syndromes (ME 375)

It is the goal of the submitted project to investigate a possible link of genetic predisposition and immunological features in autoimmune polyglandular syndromes (APS). One important question is whether or not clinically silent and ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2000 - 2002
    • •
  • 1 510 tis. Kč
    • •
  • 880 tis. Kč
    • •
  • MŠMT
Project

Genetic predisposition and new biochemical markers of cardiovascular risk in patients with chronic kidney diseases. (NS10043)

The aim of the project is to study genetic predisposition and new biochemical markers of cardiovascular risk in patients with kidney diseases. Studies will be aimed at selected polymorphisms of the gene for PAPP-A and new biochemica...

FP - Ostatní lékařské obory

  • 2008 - 2011
    • •
  • 4 892 tis. Kč
    • •
  • 4 892 tis. Kč
    • •
  • MZ
Project

Genetic predisposition to osteoporosis. (NB7380)

An analysis of the association between common polymorphisms in the transforming growth factor beta -1, plasminogen-activator inhibitor and collagen type 1 genes and osteoporosis.......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2003 - 2005
    • •
  • 2 574 tis. Kč
    • •
  • 2 573 tis. Kč
    • •
  • MZ
Project

BIOINFORMATICS AND FUNCTIONAL ANALYSES OF SUSCEPTIBILITY VARIANTS SUPPORTING THE NGS-BASED TESTING OF HEREDITARY CANCERS IN THE CZECH REPUBLIC (II) (NU20-03-00285)

in these activities to comprehensively characterize genetic architecture of cancer predisposition predisposition genes in high-risk individuals. Identification of causal mutation has critical laboratories unifying cancer <...

Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])

  • 2020 - 2023
    • •
  • 11 831 tis. Kč
    • •
  • 11 831 tis. Kč
    • •
  • MZ
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