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8 471 (0,162s) •

Project

Genetically modified donor T cells as a universal cell source for the immunotherapy of tumors using T lymphocytes equipped with a chimeric antigen receptor (CAR) (FV40145)

The first project goal is a functional sample of a cell line of modified donor's T-cell that will be genetically manipulated to be universally usable for any donor T-cells that will be f...

Oncology

  • 2019 - 2022
    • •
  • 15 604 tis. Kč
    • •
  • 10 922 tis. Kč
    • •
  • MPO
Project

The development of chimeric antigen receptors for the immunotherapy of lymphoma. (NT14030)

modified cells. After expansion in vitro we will test the T cells to eliminateT cells will be obtained from the blood of patients with B-NHL will work out procedures for large-scale T

FD - Onkologie a hematologie

  • 2013 - 2015
    • •
  • 7 435 tis. Kč
    • •
  • 7 435 tis. Kč
    • •
  • MZ
Project

New approaches to Chimeric Antigen Receptor T cells analysis of RASAL3 protein function and identification of novel CAR-T activity-modifying genes (GA22-35273S)

Chimeric Antigen Receptor (CAR) T cells achieved remarkable success in treating to the original promises. Novel designs of CAR-T cells are urgently needed with further function of RASAL3, a negative regulator of

Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)

  • 2022 - 2024
    • •
  • 8 916 tis. Kč
    • •
  • 8 814 tis. Kč
    • •
  • GA ČR
Project

Adoptive immunotherapy of hematological malignancies in elderly patients preclinical and clinical study (NV16-34405A)

genetically modified in order to express chimeric antigen receptors targeting suitable AML supportive data in order to submit ambitious clinical trial of gene modified CIK cells natural killer (NK) cells ...

FD - Onkologie a hematologie

  • 2016 - 2019
    • •
  • 10 994 tis. Kč
    • •
  • 10 994 tis. Kč
    • •
  • MZ
Project

Gene engineered killer T cells for the therapy of acute myeloid leukemia. (NU22-05-00374)

based on genetically modified autologous T lymphocytes. This procedure is based on a genetic modification by a recombinant T-cell receptor (TCR), which redirects will be to develop a GMP-certifie...

Hematology

  • 2022 - 2025
    • •
  • 15 840 tis. Kč
    • •
  • 15 840 tis. Kč
    • •
  • MZ
Project

The regulation of immunity in syndrome diGeorge (NT13287)

functions. We plan to investigate in a prospective study not only T cells that were in past studied in detail, but also B cells potentially affected by impaired T cells help. We also plan to investigate <...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2012 - 2015
    • •
  • 9 183 tis. Kč
    • •
  • 9 183 tis. Kč
    • •
  • MZ
Project

Molecular characterization of autoimmune polyglandular syndromes (ME 375)

studies will focus on both B- and T-cell mediated autoimmune responses. A broad range and specific diagnosis of APS. Because the T-cell mediated autoimmune response is crucial T-cells and the Th1...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2000 - 2002
    • •
  • 1 510 tis. Kč
    • •
  • 880 tis. Kč
    • •
  • MŠMT
Project

Novel treatment of genetically determined metabolic disease, type 1 diabetes, using an immunotherapeutical approach. (2B08066)

would lead to clinical application of immunological preparation based on genetically modified tolerogenic T lymphocytes and dendritic cells. This therapeutical approachThe aim of the proposed project is a characte...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2008 - 2011
    • •
  • 44 736 tis. Kč
    • •
  • 38 751 tis. Kč
    • •
  • MŠMT
Project

Porcine reproductive and respiratory syndrome virus (PRRSV) alters thymocyte development and repertoire of T lymphocytes (GA20-03282S)

antigen presenting cells, which play a critical role in T cell development during selection of T cell repertoire. Alternatively, PRRSV may directly influence thymocytes and modify their developme...

Veterinary science

  • 2020 - 2022
    • •
  • 10 513 tis. Kč
    • •
  • 10 513 tis. Kč
    • •
  • GA ČR
Project

Genetically downregulated expression of the immune checkpoint inhibitor LAIR-1 in tumor-specific T cells as a novel strategy for breaking the resistance of solid tumors to adoptive T cell (NU23-08-00071)

of technology for ex vivo production of tumor-specific T cells with genetically patients with solid tumors still do not benefit from this therapy. Adoptive T cell in the treatment of solid tumors. The fai...

Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)

  • 2023 - 2026
    • •
  • 11 244 tis. Kč
    • •
  • 11 244 tis. Kč
    • •
  • MZ
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