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13 (0,068s) •

Project

Application of tumor tropism of stem cells for photothermal therapy of glioblastoma with gold nanorods - a preclinical study (NV19-08-00523)

Glioblastoma multiforme is a brain tumor with incidence of 2-3/100000 persons and generally poor prognosis. In this study we want to employ a new approach of photothermal cancer therapy using gold nanorods (GNRs) with potential to eradicate also the ...

Oncology

  • 2019 - 2023
    • •
  • 12 173 tis. Kč
    • •
  • 12 173 tis. Kč
    • •
  • MZ
Project

Diagnosis and management of glioblastoma patients with rapid early progression before the initiation of adjuvant oncology treatment (NU20-03-00148)

Glioblastoma is the most common and aggressive primary brain tumor. It is characterized by unfavorable prognosis with almost inevitable progression even after multimodal treatment. With increased magnetic resonance (MR) availability, early postoperat...

Oncology

  • 2020 - 2024
    • •
  • 9 842 tis. Kč
    • •
  • 9 806 tis. Kč
    • •
  • MZ
Project

Imunopathologic mechanisms of the genesis, the course and therapy response in glioblastoma (NV17-32758A)

Glioblastoma multiforme (GBM) is considered to be one of the most deadly human cancers, which responds poorly to both traditional and experimental therapeutic approaches, stubbornly persisting with a dismal survival of about 12–15 months. CNS has bee...

FD - Onkologie a hematologie

  • 2017 - 2021
    • •
  • 5 623 tis. Kč
    • •
  • 5 596 tis. Kč
    • •
  • MZ
Project

Novel concepts for the therapeutic targeting of tumor microenvironment in human glioblastomas (NV15-31379A)

Fibroblast activation protein (FAP) is a protease selectively expressed in the microenvironment of several tumors including high grade gliomas (HGG). Due to its minimal expression in healthy tissues, the protease is a proposed therapeutic target in e...

FD - Onkologie a hematologie

  • 2015 - 2019
    • •
  • 15 595 tis. Kč
    • •
  • 15 595 tis. Kč
    • •
  • MZ
Project

Biomarkers mapping at the infiltration zone of glioblastomas and their topographic relationship to an early relapse. (NU23-03-00100)

Glioblastoma is the most aggressive glioma with progressive behavior and dismal prognosis. The main obstacles to effective treatment of glioblastoma is invasive growth into a peritumoral brain zone limiting effect of surgery and intratumoral heteroge...

Oncology

  • 2023 - 2026
    • •
  • 13 669 tis. Kč
    • •
  • 13 669 tis. Kč
    • •
  • MZ
Project

Study of PIWI-interacting RNAs in glioblastoma stem cells and their potential clinical implications (NV19-03-00501)

Glioblastoma (GBM) is the most frequent primary brain tumor of astrocytic origin. Despite great advances in molecular pathology and oncology, there is still no clinically applicable ways to classify patients according their prognosis and to overcome ...

Oncology

  • 2019 - 2023
    • •
  • 12 684 tis. Kč
    • •
  • 12 684 tis. Kč
    • •
  • MZ
Project

Role of cytotoxic gamma-delta T cells implicated in therapeutic resistence and tumour recurrence in Glioblastoma Multiforme (NV19-05-00410)

Glioblastoma multiforme (GBM) is the common malignant brain tumour in adults and despite aggressive treatment it remains virtually incurable with a poor prognosis and median survival of 12 months following resection, radiotherapy and chemotherapy. Th...

Immunology

  • 2019 - 2023
    • •
  • 9 480 tis. Kč
    • •
  • 9 439 tis. Kč
    • •
  • MZ
Project

New level of glioblastoma molecular taxonomy based on the expression profiling of long non-coding RNAs implications for diagnosis and therapy (NV15-33158A)

Glioblastoma multiforme (GBM) is the most frequent primary brain tumor with median survival approximately 13 months from diagnosis. The prognosis varies considerably from patient to patient, whereas the histopathological examination has no ability to...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 9 938 tis. Kč
    • •
  • 9 938 tis. Kč
    • •
  • MZ
Project

Unraveling Molecular Mechanisms of Glioblastoma Treatment Resistance and Recurrence Insights from a 3D GLICO Model (NW24-08-00157)

Glioblastoma IDH-wildtype WHO G4 (GB) is a primary malignant brain tumor characterized by its resistance to therapy and poor prognosis. Despite advances in surgical techniques, targeted radiotherapy, and chemotherapeutics, GB remains incurable with l...

Cell biology

  • 2024 - 2027
    • •
  • 13 773 tis. Kč
    • •
  • 13 773 tis. Kč
    • •
  • MZ
Project

Proteomic Portrait of Glioblastoma a way to Stratified Therapy (NW25-03-00131)

Glioblastoma (GBM) is the most aggressive and common primary brain tumor in adults. Standard treatments include surgery followed by concomitant chemoradiotherapy, but the prognosis remains poor, with an overall survival rate of about 21.8 months. Adv...

Oncology

  • 2025 - 2028
    • •
  • 14 605 tis. Kč
    • •
  • 14 605 tis. Kč
    • •
  • MZ
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