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46 (0,119s) •

Project

The function of FGFR2 cilia localization in glioblastoma pathogenesis (NW24-08-00364)

Glioblastoma is the most prevalent primary brain cancer in adults. The current of the glioblastoma patients, in which the disease quickly takes over due to therapy-resistant cancer stem cells. Studies expanding on mechanisms of ...

Oncology

  • 2024 - 2027
    • •
  • 14 710 tis. Kč
    • •
  • 14 710 tis. Kč
    • •
  • MZ
Project

Critical interactions of neuronal transcription factor REST with stabilizer TRF2 biophysical implications for anti-glioblastoma drug design (GA19-18226S)

Glioblastoma is the most common and malignant brain tumor in adults. So far, there has been no successful glioblastoma treatment. The only option for patients with glioblastoma located close to brain areas controlling criti...

Biophysics

  • 2019 - 2023
    • •
  • 7 217 tis. Kč
    • •
  • 6 998 tis. Kč
    • •
  • GA ČR
Project

The role of transcription regulation in chemotherapeutic resistance of glioblastoma in vitro and in vivo validations of targets for molecular therapy (LTAUSA19024)

Glioblastoma is the most common and malignant brain tumor in adults. So far, there has been no successful nonoperative treatment of glioblastoma. The only option for patients with glioblastoma located close to brain areas c...

Biophysics

  • 2020 - 2022
    • •
  • 4 226 tis. Kč
    • •
  • 4 226 tis. Kč
    • •
  • MŠMT
Project

Mechanisms of immunoresistance in glioblastoma (NS9875)

Submitted project deals with the immunosuppresive effects of glioblastoma cells caused by overexpression of transforming growth factor beta and contributes to enhancement of current cellular immunotherapy.......

FD - Onkologie a hematologie

  • 2008 - 2011
    • •
  • 9 724 tis. Kč
    • •
  • 9 724 tis. Kč
    • •
  • MZ
Project

Identification and functional characterization of microRNAs with predictive significance in patients with glioblastoma (NT11214)

The main goal of our project is to extend knowledge about molecular mechanisms involved in glioblastoma carcinogenesis and invasivness by analysis of microRNA expression profiles in primary tumors and use our findings for prediction of respo...

FD - Onkologie a hematologie

  • 2010 - 2013
    • •
  • 5 548 tis. Kč
    • •
  • 5 548 tis. Kč
    • •
  • MZ
Project

MicroRNA analysis in glioblastoma stem cells prediction of therapy response and identification of new therapeutic targets in glioblastoma patients (NT13514)

The main aim of our project is to contribute to the molecular characterization of glioblastoma stem cells (GSCs) which are responsible for resistance to the therapy and relapse of glioblastoma (GBM). MiRNA expression profiles of GSC...

FD - Onkologie a hematologie

  • 2012 - 2015
    • •
  • 6 961 tis. Kč
    • •
  • 6 961 tis. Kč
    • •
  • MZ
Project

Analysis and targeting of DNA damage signaling and repair mechanisms in glioblastomas and glioblastoma stem cells as a strategy to elucidate pathogenesis and search for individualized targeted (NT11065)

Analysis and targeting of DNA damage signaling and repair mechanisms in glioblastomas and glioblastoma stem cells as a strategy to elucidate pathogenesis and search) in glioblastoma, aiming at better understanding of molecu...

FD - Onkologie a hematologie

  • 2010 - 2014
    • •
  • 8 112 tis. Kč
    • •
  • 8 112 tis. Kč
    • •
  • MZ
Project

Biomarkers mapping at the infiltration zone of glioblastomas and their topographic relationship to an early relapse. (NU23-03-00100)

Glioblastoma is the most aggressive glioma with progressive behavior and dismal prognosis. The main obstacles to effective treatment of glioblastoma is invasive growth need therapy any more. Due to a high intratumoral heterogeneity ...

Oncology

  • 2023 - 2026
    • •
  • 13 669 tis. Kč
    • •
  • 13 669 tis. Kč
    • •
  • MZ
Project

Regulation of microtubule formation in brain cancer cells (LH12050)

regulating microtubules in glioblastoma cell lines and gliomas 3. To characterize specific properties of gamma-tubulins in glioblastomas 4. To determine the role of microtubule regulatory proteins in glioblastoma cell prol...

EA - Morfologické obory a cytologie

  • 2012 - 2015
    • •
  • 3 432 tis. Kč
    • •
  • 3 272 tis. Kč
    • •
  • MŠMT
Project

Role of GIT proteins in regulation of microtubule organization in glioblastoma cells (LTAUSA19118)

Diffuse glioblastoma is the most frequent and most malignant form of primary feature of glioblastoma cells. Our recent data indicate that GIT1 signaling protein which regulates cell motility is overexpressed in highly motile gli...

Biochemistry and molecular biology

  • 2020 - 2022
    • •
  • 3 900 tis. Kč
    • •
  • 3 900 tis. Kč
    • •
  • MŠMT
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