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2 111 (0,2s) •

Project

High-affinity protein binders of hepatitis C virus broadly-neutralizing antibodies as a base for preventative vaccine (NU23-05-00203)

of effective protective vaccine inducing antibodies neutralizing broad spectrum of HCV inducing broadly HCV neutralizing sera as the base for future preventative HCVMore than 130 million people worldwide ...

Immunology

  • 2023 - 2026
    • •
  • 13 783 tis. Kč
    • •
  • 13 783 tis. Kč
    • •
  • MZ
Project

Molecular epidemiology of hepatitis C virus in the Czech Republic (NR9044)

Set up of sequence analysis of PCR fragments of HCV genome isolates. Obtaining of basic data about variability of HCV in infected persons from low-risk group of blood sequences of HCV isolates from Czech Republic. Mapping o...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2006 - 2008
    • •
  • 3 265 tis. Kč
    • •
  • 3 028 tis. Kč
    • •
  • MZ
Project

Research and development of comprehensive measures for the control of infectious inflammation of the bovine mammary gland (LF15023)

The project aims to develop a set of comprehensive preventive measures (improvement of breeding/milking, isolation of pathogens, production of specific vaccine) that would reduce the frequency and severity of mastitis in cattle.......

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2015 - 2017
    • •
  • 7 136 tis. Kč
    • •
  • 3 568 tis. Kč
    • •
  • MŠMT
Project

HBV DNA Quantification and Determibation of HCV Serotype Extension of Selection Criteria in Patients with Chron.VHB,VHC Indicated for Interferon Therapy. (IZ3692)

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1996 - 1998
    • •
  • 2 079 tis. Kč
    • •
  • 2 079 tis. Kč
    • •
  • MZ
Project

Role of heme oxygenase in the pathogenesis of hepatocelular injury in chronic HCV infection (NR9412)

In the presented project, the role of hemooxygenase 1 and 2 in the procesess associated with fibroproduction in the chronic HCV infection will be studied of the chronic HCV infection. Our expected results may help understanding the ...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2007 - 2010
    • •
  • 4 641 tis. Kč
    • •
  • 4 467 tis. Kč
    • •
  • MZ
Project

Immune mechanisms of gliadin/gluten in pathogenesis and prevention of type 1 diabetes two immuno-preventive strategies for translation to humans. (GA15-24487S)

to identify regulatory mechanisms or cell subsets in prevention of T1D by i.n. vaccination highly prevents development of T1D and also that mucosal, i.n. administration of gliadin prevents T1D in NOD mice. We will...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2015 - 2018
    • •
  • 5 277 tis. Kč
    • •
  • 5 277 tis. Kč
    • •
  • GA ČR
Project

Multiple purpose survey of seroprevalence towards selected infections (preventable, against which vaccination is beig carried out) (NI7397)

Multipurpose cross-sectional serological study of the population of the Czech Republic assessing and monitoring nationwide vaccination campaigns, estimating the potential risks of more serious infections, reflecting the changing characterist...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2003 - 2003
    • •
  • 3 772 tis. Kč
    • •
  • 2 081 tis. Kč
    • •
  • MZ
Project

Prevention of allergies by colonization of the intestine with a nonpathogenic E.coli strain (vaccine COLINFANT) administered orally at birth to infants of allergic mothers. Long-term study (NI7525)

Preventing development of allergy by oral colonization of intestine of infants of allergic mothers with strain E.coli (vaccine Colinfant) after birth in a double-blind study. Follow development of immune reactions in colonized infan...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2003 - 2005
    • •
  • 6 975 tis. Kč
    • •
  • 6 681 tis. Kč
    • •
  • MZ
Project

Immunohistochemical detection of predictive factors of response to interferon therapy in patients with chronic hepatitis C (NR7814)

Hepatitis C virus (HCV) related alteration of signalling pathways and proteins (Jak-Stat, ERK1/2, NF-kB, MAP, etc.) regulated/activated by interferon (IFN) may lead to resistance to IFN treatment of patients with HCV infection. ...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 1 733 tis. Kč
    • •
  • 1 618 tis. Kč
    • •
  • MZ
Project

Intranasal vaccination in prevention of autoimmune diseases (NS10340)

and kinetics of induction of regulatory cells after i.n. vaccination. Nasal mucosa-induced subsets of regulatory cells and their functional capacity to prevent autoimmune......

EC - Imunologie

  • 2009 - 2011
    • •
  • 2 561 tis. Kč
    • •
  • 2 561 tis. Kč
    • •
  • MZ
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