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5 322 (0,189s) •

Project

Sensing of HIV-1 by plasmacytoid dendritic cells dichotomy of immunoreceptor signaling (GA14-32547S)

interferon (IFN-I) in human organism, in pathogenesis of HIV-1 infection is not clear. In contrast to HIV-1 infected lymphocytes, HIV-1 virions are weak inducers of IFN-I. Exposure of pDCs to

EE - Mikrobiologie, virologie

  • 2014 - 2018
    • •
  • 6 397 tis. Kč
    • •
  • 6 397 tis. Kč
    • •
  • GA ČR
Project

The role of DNA methylation and histone modifications in the establishment and maintenance of HIV-1 latency (GP204/08/P616)

for eradication of HIV-1 infection. We found that CpG methylation of the HIV-1 promoter in 5?LTR is not needed for establishment of HIV-1 latency but controls the stringency oftranscriptional sil...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 1 500 tis. Kč
    • •
  • 1 500 tis. Kč
    • •
  • GA ČR
Project

NEW POSSIBILITIES IN THERAPY OF HIV/AIDS DISEASE ROLE OF HEME OXYGENASE, BILIVERDIN REDUCTASE AND THE EFFECTS OF HEME ARGINATE ON REPLICATION AND REACTIVATION OF HIV-1 (NT14135)

Goals of the project: 1/ To verify and further study effects of HA on HIV-1 HA effect on acute infection of PBMC's of healthy donors with HIV-1 b/ To study HA effect on reactivation of HIV-1

EE - Mikrobiologie, virologie

  • 2013 - 2015
    • •
  • 6 216 tis. Kč
    • •
  • 6 084 tis. Kč
    • •
  • MZ
Project

Identification of the subtypes and study of genetic variants of HIV-1 in the Czech Republic (NI5174)

Genetic characterization of HIV-1 strains in the Czech Republic. Determination of genetic subtypes, strains resistant to antiretroviral therapy. Comparison of genotypes of the selected HIV-1 strains with their biol...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1999 - 2001
    • •
  • 3 095 tis. Kč
    • •
  • 1 374 tis. Kč
    • •
  • MZ
Project

Early detection of neurological complications of HIV-1 infection (NI5673)

Prospective study for early detection of HIV-1 associated neurological diseases is proposed. Non-invasive neuropsychological and electrophysiological screening battery screening of HIV-1 positive patients will be s...

FH - Neurologie, neurochirurgie, neurovědy

  • 1999 - 2001
    • •
  • 855 tis. Kč
    • •
  • 855 tis. Kč
    • •
  • MZ
Project

Fullerene inhibitors of HIV-1 (LTAUSA17061)

The objectives of the proposed project are: a) to verify and characterize the inhibitory activity of fullerene inhibitors targeting the process of assembly of immature and mature HIV particles b) to characterize the mechanism of inhibition...

EB - Genetika a molekulární biologie

  • 2017 - 2021
    • •
  • 4 103 tis. Kč
    • •
  • 4 103 tis. Kč
    • •
  • MŠMT
Project

Development of CpG methylation of HIV-1 promoter and its stabilizing effect on the latent provirus reservoir longitudinal study in patients (GAP304/12/1736)

Existence of latent HIV-1 reservoir makes the eradication of HIV-1 infection methylation of the 5' LTR tightly controls resistance of latent HIV-1 to reactivation and thus determines the stability...

EE - Mikrobiologie, virologie

  • 2012 - 2016
    • •
  • 3 885 tis. Kč
    • •
  • 3 885 tis. Kč
    • •
  • GA ČR
Project

Novel approaches towards anti - HIV -1 DNA vaccine (ME 875)

study of biodistribution of DNA/Gal-lipolex complexes and immunity response to gp120+MBLDNA/Gal-lipolex immunisation, comparison of HIV-- glycosylation concensus B gp 120 antigene exprimed in different tissue cells......

EC - Imunologie

  • 2006 - 2009
    • •
  • 1 785 tis. Kč
    • •
  • 1 685 tis. Kč
    • •
  • MŠMT
Project

Construction of recombinant mimotopes for induction of neutralizing antibodies against HIV-1 gp120 glycoprotein using high-affinity binders approach (NV15-32198A)

Development of vaccine preventing HIV-1 infection is hindered by high variability of envelope glycoprotein (Env), known target for neutralizing antibodies. Identification of several monoclonal antibodies neutralizing broad range of...

EC - Imunologie

  • 2015 - 2018
    • •
  • 6 200 tis. Kč
    • •
  • 6 200 tis. Kč
    • •
  • MZ
Project

Study of the role of capsid protein in early phase of HIV-1 replication cycle using the newly identified compounds stabilizing capsid complexes (GA17-25602S)

, (PF74 and BI), inhibiting HIV-1 at early infection stages, MACs increase the rate of HIV-1 CA multimerization in vitro. MACs may thus represent potential antivirotics blocking the core uncoating in the early phas...

EE - Mikrobiologie, virologie

  • 2017 - 2019
    • •
  • 5 271 tis. Kč
    • •
  • 4 929 tis. Kč
    • •
  • GA ČR
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