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9 (0,075s) •

Project

Production of recombinant DNA-binding protein HMGB1 for diagnostic application (FR-TI4/504)

This project is focused on the development of immunoanalytical kit for HMGB1 protein quantification in biological samples. The final usage of the kit HMGB1 and monoclonal antibodies against HMGB1. Recombinant HMGB1...

EI - Biotechnologie a bionika

  • 2012 - 2015
    • •
  • 17 650 tis. Kč
    • •
  • 13 824 tis. Kč
    • •
  • MPO
Project

Understanding of HMGB1 protein involvement in maintaining genome stability (GA204/08/1530)

HMGB1 is a relatively abundant chromatin-associated protein and recent data indicated striking chromosomal instability in HMGB1 knock-outed primary mouse embryonic that deficiency of HMGB1 in mouse cells resulted in lower t...

CE - Biochemie

  • 2008 - 2010
    • •
  • 4 887 tis. Kč
    • •
  • 4 887 tis. Kč
    • •
  • GA ČR
Project

Electrochemical immunosensor for the detection of HMGB1 in serum of leukemia patients a tool for rapid assessment of treatment success (NU20-08-00106)

of chromosomal protein HMGB1 is significantly associated with poorer survival of cancer patients. Available data suggest that determination of HMGB1 level in sera of cancer for quantitative determination of HMGB1 levels in...

Cell biology

  • 2020 - 2023
    • •
  • 7 325 tis. Kč
    • •
  • 7 325 tis. Kč
    • •
  • MZ
Project

HMGB1 protein involvement in nucleosome dynamics and transcription factors binding (GA15-01354S)

by chromatin-associated protein HMGB1. Recently we have demonstrated that redox state of HMGB1 can modulate the ability of the protein to displace H1 from naked DNA [PlosOne of HMGB1 on (i) nucleosome dynamics, (ii) histon...

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 4 844 tis. Kč
    • •
  • 4 844 tis. Kč
    • •
  • GA ČR
Project

HMGB proteins involvement in biology of telomeres and human embryonic stem cells (GAP305/12/2475)

Recently we have observed that deficiency of chromosomal HMGB1 protein (involved in transcription, DNA repair, genomic stability and cellular signaling the impact of deregulated expression of HMGB1 or other HMGBs (silencing by shRNA...

EB - Genetika a molekulární biologie

  • 2012 - 2015
    • •
  • 9 740 tis. Kč
    • •
  • 9 740 tis. Kč
    • •
  • GA ČR
Project

HMGB1 role in modulation of tumor suppressors and telomere integrity (GA204/05/2031)

p53 is a crucial tumor suppressor for preventing malignant transformation of cells by inducing cell-cycle arrest and apoptosis. These two mutually exclusive fates can not be specified by p53 (or p73, a member of p53 family) alone, but by the tumor su...

CE - Biochemie

  • 2005 - 2007
    • •
  • 3 528 tis. Kč
    • •
  • 3 528 tis. Kč
    • •
  • GA ČR
Project

Hemicatenated DNA loops their occurence in humen genome and recognition by tumor suppressor protein p53 (IAA400040702)

(hcDNA). hcDNA is specifically recognized and bound by HMGB1 protein which has been...

CE - Biochemie

  • 2007 - 2010
    • •
  • 2 428 tis. Kč
    • •
  • 2 428 tis. Kč
    • •
  • AV ČR
Project

A modification of a gut microbiota as a prevention of enteric diseases in newborns a study in a piglet gnotobiotic model (LD15090)

) and a nuclear protein HMGB1 that indicates severity of the enteric infection. The study...

EE - Mikrobiologie, virologie

  • 2015 - 2017
    • •
  • 1 608 tis. Kč
    • •
  • 1 608 tis. Kč
    • •
  • MŠMT
Project

Advanced Magnetic Nanorobots for Targeted Mitigation of Sepsis and Inflammation-Induced Tissue Damage. (NW25-08-00352)

quantification (e.g., HMGB1) directly in small volume of patient’ sample (e.g., drop of blood)....

Medical engineering

  • 2025 - 2028
    • •
  • 11 895 tis. Kč
    • •
  • 11 895 tis. Kč
    • •
  • MZ
  • 1 - 9 out of 9